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Results for "

Lenalidomide-

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (2) Apoptosis (17) ATM/ATR (1) Btk (3) c-Myc (1) Casein Kinase (1) Caspase (2) CDK (6) DNA/RNA Synthesis (6) Drug Derivative (1) Drug Intermediate (1) Drug Isomer (4) Drug Metabolite (2) E1/E2/E3 Enzyme (1) E3 Ligase Ligand-Linker Conjugates (72) Epigenetic Reader Domain (3) Ferroptosis (1) FLT3 (1) Fluorescent Dye (1) Glutathione Peroxidase (1) Histone Methyltransferase (1) Isotope-Labeled Compounds (4) Ligands for E3 Ligase (70) Ligands for Target Protein for PROTAC (3) MDM-2/p53 (1) MEK (1) Mixed Lineage Kinase (1) Molecular Glues (9) PAK (1) PERK (1) PROTAC Linkers (2) PROTACs (17) Reference Standards (6) RET (1) STAT (2) TGF-beta/Smad (1) TNF Receptor (1) Transmembrane Glycoprotein (1)
By Research Areas:	Cancer (164) Endocrinology (1) Inflammation/Immunology (11) Metabolic Disease (1)
Click Chemistry:	PROTAC Synthesis (4) Azide (7) Alkynes (3)

181

Inhibitors & Agonists

Screening Libraries

Peptides

Inhibitory Antibodies

Isotope-Labeled Compounds

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-A0003

*Lenalidomide* Maximum Cited Publications 59 Publications Verification CC-5013	Ligands for E3 Ligase Molecular Glues Apoptosis	Inflammation/Immunology Cancer
Lenalidomide (CC-5013), a derivative of Thalidomide, acts as molecular glue. Lenalidomide is an orally active immunomodulator. Lenalidomide (CC-5013) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide (CC-5013) specifically inhibits growth of mature B-cell lymphomas, including multiple myeloma, and induces IL-2 release from T cells .

HY-W077589

Lenalidomide-5-aminomethyl hydrochloride	Ligands for E3 Ligase	Cancer
Lenalidomide-5-aminomethyl hydrochloride is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-5-aminomethyl hydrochloride can be connected to the ligand for protein by a linker to form PROTAC

HY-P10899

ETTAC-2	PROTACs TGF-beta/Smad	Endocrinology
ETTAC-2 is a LRG1 PROTAC degrader, degrading LRG1 via the ubiquitin-proteasome pathway with a DC₅₀ value of 8.38 μM. ETTAC-2 penetrates damaged renal cells to reduce the extracellular secretion of LRG1. ETTAC-2 effectively inhibits the TGF-β-Smad3 signaling pathway and diminishes the secretion of fibrosis-associated extracellular matrix proteins. ETTAC-2 degrades LRG1 within fibrotic kidneys and the efficacy in inhibiting the TGF-β-Smad3 pathway both in vitro and vivo. ETTAC-2 can be used for renal fibrosis research .

HY-132248

C5 Lenalidomide Lenalidomide 5'-amine	Drug Derivative TNF Receptor	Inflammation/Immunology
C5 Lenalidomide is a 5-amino-substituted Thalidomide (HY-14658) analog. C5 Lenalidomide inhibits LPS (HY-D1056)-stimulated TNF-α production .

HY-W072954

Lenalidomide-5-Br	Ligands for E3 Ligase	Cancer
Lenalidomide-5-Br is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-5-Br can be connected to the ligand for protein by a linker to form PROTAC .

HY-133144

Lenalidomide-OH	Ligands for E3 Ligase	Cancer
Lenalidomide-OH is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. Lenalidomide-OH can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC BTK degrader SJF620 (HY-133137) .

HY-A0003B

Lenalidomide hemihydrate Maximum Cited Publications 59 Publications Verification CC-5013 hemihydrate	Ligands for E3 Ligase Molecular Glues Apoptosis	Cancer
Lenalidomide hemihydrate (CC-5013 hemihydrate), a derivative of Thalidomide, acts as molecular glue. Lenalidomide hemihydrate is an orally active immunomodulator. Lenalidomide hemihydrate (CC-5013 hemihydrate) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide hemihydrate (CC-5013 hemihydrate) specifically inhibits growth of mature B-cell lymphomas, including multiple myeloma, and induces IL-2 release from T cells .

HY-133139

Lenalidomide-PEG1-azide	E3 Ligase Ligand-Linker Conjugates	Cancer
Lenalidomide-PEG1-azide is a E3 ligase lgand-linker conjugate. Lenalidomide-PEG1-azide incorporates the Lenalidomide based cereblon ligand and a linker.?Lenalidomide-PEG1-azide?can be used to design a PROTAC BRD4 Degrader-2 (HY-133136) . Lenalidomide-PEG1-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-W259932

Lenalidomide 5'-piperazine hydrochloride	Ligands for E3 Ligase	Cancer
Lenalidomide 5'-piperazine hydrochloride can serve as a Cereblon ligand to recruit CRBN protein. Lenalidomide 5'-piperazine hydrochloride can be linked to target protein ligands via a linker to form PROTAC molecules, such as KI-CDK9d-32 (HY-173523) .

HY-122725B

Lenalidomide-C5-NH2 hydrochloride	E3 Ligase Ligand-Linker Conjugates	Cancer
Lenalidomide-C5-NH2 hydrochloride is an E3 ligase ligand-linker conjugate. Lenalidomide-C5-NH2 hydrochloride can be coupled to a target protein ligand via a linker to form a PROTAC molecule—such as a PROTAC degrader for MDM2 .

HY-W039233

Lenalidomide-F	Ligands for E3 Ligase	Cancer
Lenalidomide-F is a E3 ligase ligand for LWY713. LWY713 is a PROTAC-class FLT3 degrader (DC₅₀ = 0.64 nM), which selectively induces FLT3 degradation via cereblon and proteasome-dependent pathways .

HY-138881

Lenalidomide-6-F	Ligands for E3 Ligase	Cancer
Lenalidomide-6-F is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-6-F can be connected to the ligand for protein by a linker to form PROTAC .

HY-131318

Lenalidomide-I	Ligands for E3 Ligase	Cancer
Lenalidomide-I (Compound 72), an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, is used in the recruitment of CRBN protein. Lenalidomide-I can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC BET degrader QCA570 (HY-112609) .

HY-132226

*Desamino lenalidomide-5-F*	Ligands for E3 Ligase	Cancer
Desamino lenalidomide-5-F is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. Desamino lenalidomide-5-F can be linked to a target protein ligand via a linker to form a PROTAC.

HY-43722

Lenalidomide-Br	Ligands for E3 Ligase	Cancer
Lenalidomide-Br (Compound 41) is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. Lenalidomide-Br can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC STAT3 degrader SD-36 (HY-129602) .

HY-130683

Lenalidomide-propargyl-C2-NH2 hydrochloride 1 Publications Verification	E3 Ligase Ligand-Linker Conjugates	Cancer
Lenalidomide-propargyl-C2-NH2 hydrochloride incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase, and a linker. Lenalidomide-propargyl-C2-NH2 hydrochloride can be used to design the PROTAC MD-224 (HY-114312) . Lenalidomide-propargyl-C2-NH2 (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-160241

Lenalidomide-C5-acid	E3 Ligase Ligand-Linker Conjugates	Cancer
Lenalidomide-C5-acid is the Lenalidomide-based E3 ligase ligand-linker conjugate used in the recruitment of CRBN protein. Lenalidomide-C5-acid can be used to synthesize PROTACs .

HY-W079257

*Desamino lenalidomide-7-F*	Ligands for E3 Ligase	Cancer
Desamino lenalidomide-7-F is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. Desamino lenalidomide-7-F can be linked to a target protein ligand via a linker to form a PROTAC.

HY-W244728

*Desamino lenalidomide-pinacolborane*	Ligands for E3 Ligase	Cancer
Desamino lenalidomide-pinacolborane is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. Desamino lenalidomide-pinacolborane can be linked to a target protein ligand via a linker to form a PROTAC.

HY-A0003R

Lenalidomide (Standard) CC-5013 (Standard)	Reference Standards Ligands for E3 Ligase Molecular Glues Apoptosis	Inflammation/Immunology Cancer
Lenalidomide (Standard) is the analytical standard of Lenalidomide. This product is intended for research and analytical applications. Lenalidomide (CC-5013), a derivative of Thalidomide, acts as molecular glue. Lenalidomide is an orally active immunomodulator. Lenalidomide (CC-5013) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide (CC-5013) specifically inhibits growth of mature B-cell lymphomas, including multiple myeloma, and induces IL-2 release from T cells .

HY-161128

Lenalidomide 4'-PEG1-amine dihydrochloride	E3 Ligase Ligand-Linker Conjugates	Cancer
Lenalidomide 4'-PEG1-amine dihydrochloride is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide 4'-PEG1-amine dihydrochloride can be connected to the ligand for protein by a linker to form PROTAC .

HY-122725

Lenalidomide-C5-NH2	E3 Ligase Ligand-Linker Conjugates	Cancer
Lenalidomide-C5-NH2 is an E3 ligase ligand-linker conjugate. Lenalidomide-C5-NH2 can be coupled to a target protein ligand via a linker to form a PROTAC molecule—such as a PROTAC degrader for MDM2 .

HY-157566

Lenalidomide 5'-piperazine-4-methylpiperidine hydrochloride	Ligands for E3 Ligase	Cancer
Lenalidomide 5'-piperazine-4-methylpiperidine hydrochloride is a functionalized cerebellar ligand for PROTAC development, combining E3 ligand and terminal piperidine for subsequent chemical reactions. A protein degradant with a rigid connector is generated .

HY-145461

Hydroxy lenalidomide 5-Hydroxy Lenalidomide	Drug Metabolite	Others
Hydroxy lenalidomide (5-Hydroxy lenalidomide) is a metabolite of lenalidomide that is present as a minor component in plasma and excreta, accounting for less than 5% of the total radioactivity, following oral administration of lenalidomide in healthy male subjects.

HY-138882A

Lenalidomide-4-aminomethyl hydrochloride	Ligands for E3 Ligase	Cancer
Lenalidomide-4-aminomethyl hydrochloride is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-4-aminomethyl hydrochloride can be connected to the ligand for protein by a linker to form PROTAC

HY-W458077

*Desamino lenalidomide-7-OH*	Ligands for E3 Ligase	Cancer
Desamino lenalidomide-7-OH is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. Desamino lenalidomide-7-OH can be linked to a target protein ligand via a linker to form a PROTAC.

HY-W586326

*Desamino lenalidomide-4-COOH*	Ligands for E3 Ligase	Cancer
Desamino lenalidomide-4-COOH is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. Desamino lenalidomide-4-COOH can be linked to a target protein ligand via a linker to form a PROTAC.

HY-W586342

*Desamino lenalidomide-COOH*	Ligands for E3 Ligase	Cancer
Desamino lenalidomide-COOH is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. Desamino lenalidomide-COOH can be linked to a target protein ligand via a linker to form a PROTAC.

HY-W580776

*Desamino lenalidomide-cyano*	Ligands for E3 Ligase	Cancer
Desamino lenalidomide-cyano is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. Desamino lenalidomide-cyano can be linked to a target protein ligand via a linker to form a PROTAC.

HY-W998267

*Desamino lenalidomide-Bpin*	Ligands for E3 Ligase	Cancer
Desamino lenalidomide-Bpin is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. Desamino lenalidomide-Bpin can be linked to a target protein ligand via a linker to form a PROTAC.

HY-161129

Lenalidomide 4'-PEG2-amine dihydrochloride	E3 Ligase Ligand-Linker Conjugates	Cancer
Lenalidomide 4'-PEG2-amine dihydrochloride is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide 4'-PEG2-amine dihydrochloride can be connected to the ligand for protein by a linker to form PROTAC .

HY-115446A

Lenalidomide-C4-NH2 hydrochloride Cereblon ligand 1 hydrochloride; E3 ligase Ligand-Linker Conjugates 32 hydrochloride	E3 Ligase Ligand-Linker Conjugates	Cancer
Lenalidomide-C4-NH2 hydrochloride is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C4-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC (Compound 24), which has IC₅₀s of 0.98 nM and 13.7 nM in inhibition of RS4;11 and MOLM-13 acute leukemia cell lines growth, respectively .

HY-W093472

*Desamino lenalidomide-6-COOH*	Ligands for E3 Ligase	Cancer
Desamino lenalidomide-6-COOH is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. Desamino lenalidomide-6-COOH can be linked to a target protein ligand via a linker to form a PROTAC.

HY-W458035

*Desamino lenalidomide-alkynes*	Ligands for E3 Ligase	Cancer
Desamino lenalidomide-alkynes is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. Desamino lenalidomide-alkynes can be linked to a target protein ligand via a linker to form a PROTAC.

HY-161130

Lenalidomide 4'-PEG3-amine dihydrochloride	E3 Ligase Ligand-Linker Conjugates	Cancer
Lenalidomide 4'-PEG3-amine dihydrochloride is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide 4'-PEG3-amine dihydrochloride can be connected to the ligand for protein by a linker to form PROTAC .

HY-A0003S

Lenalidomide-d5 CC-5013-d₅	Isotope-Labeled Compounds Ligands for E3 Ligase Molecular Glues Apoptosis	Inflammation/Immunology Cancer
Lenalidomide-d₅ is deuterium labeled Lenalidomide. Lenalidomide (CC-5013), a derivative of Thalidomide, acts as molecular glue. Lenalidomide is an orally active immunomodulator. Lenalidomide (CC-5013) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide (CC-5013) specifically inhibits growth of mature B-cell lymphomas, including multiple myeloma, and induces IL-2 release from T cells .

HY-129608

Lenalidomide-acetylene-C5-COOH Cereblon ligand-linker Conjugate	E3 Ligase Ligand-Linker Conjugates	Cancer
Lenalidomide-acetylene-C5-COOH (compound 43; Cereblon ligand-linker Conjugate) is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-acetylene-C5-COOH can be connected to the ligand for protein by a linker to form PROTAC . Lenalidomide-acetylene-C5-COOH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-W077589A

Lenalidomide-5-aminomethyl	Ligands for E3 Ligase	Cancer
Lenalidomide-5-aminomethyl is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-5-aminomethyl can be connected to the ligand for protein by a linker to form PROTAC .

HY-W586325

*Desamino lenalidomide-5-COOH*	Ligands for E3 Ligase	Cancer
Desamino lenalidomide-5-COOH is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. Desamino lenalidomide-5-COOH can be linked to a target protein ligand via a linker to form a PROTAC.

HY-W589407

*Desamino lenalidomide-6-propyne*	Ligands for E3 Ligase	Cancer
Desamino lenalidomide-6-propyne is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. Desamino lenalidomide-6-propyne can be linked to a target protein ligand via a linker to form a PROTAC.

HY-W251343

*Desamino lenalidomide-6-OH*	Ligands for E3 Ligase	Cancer
Desamino lenalidomide-6-OH is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. Desamino lenalidomide-6-OH can be linked to a target protein ligand via a linker to form a PROTAC.

HY-W244820

*Desamino lenalidomide-5-acetonitrile*	Ligands for E3 Ligase	Cancer
Desamino lenalidomide-5-acetonitrile is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. Desamino lenalidomide-5-acetonitrile can be linked to a target protein ligand via a linker to form a PROTAC.

HY-W586328

*Desamino lenalidomide-5-CO*	Ligands for E3 Ligase	Cancer
Desamino lenalidomide-5-CO is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. Desamino lenalidomide-5-CO can be linked to a target protein ligand via a linker to form a PROTAC.

HY-W589406

*Desamino lenalidomide-7-propyne*	Ligands for E3 Ligase	Cancer
Desamino lenalidomide-7-propyne is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. Desamino lenalidomide-7-propyne can be linked to a target protein ligand via a linker to form a PROTAC.

HY-W586343

*Desamino lenalidomide-7-CO*	Ligands for E3 Ligase	Cancer
Desamino lenalidomide-7-CO is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. Desamino lenalidomide-7-CO can be linked to a target protein ligand via a linker to form a PROTAC.

HY-W452755

*(R)-Desamino lenalidomide-5-Br*	Ligands for E3 Ligase	Cancer
(R)-Desamino lenalidomide-5-Br is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. (R)-Desamino lenalidomide-5-Br can be linked to a target protein ligand via a linker to form a PROTAC.

HY-W586344

*Desamino lenalidomide-4-C-COOH*	Ligands for E3 Ligase	Cancer
Desamino lenalidomide-4-C-COOH is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. Desamino lenalidomide-4-C-COOH can be linked to a target protein ligand via a linker to form a PROTAC.

HY-W586333

*Desamino lenalidomide-5-C-COOH*	Ligands for E3 Ligase	Cancer
Desamino lenalidomide-5-C-COOH is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. Desamino lenalidomide-5-C-COOH can be linked to a target protein ligand via a linker to form a PROTAC.

HY-A0003A

Lenalidomide hydrochloride CC-5013 hydrochloride	Ligands for E3 Ligase Molecular Glues	Inflammation/Immunology Cancer
Lenalidomide hydrochloride (CC-5013 hydrochloride), a derivative of Thalidomide, acts as molecular glue. Lenalidomide hydrochloride is an orally active immunomodulator. Lenalidomide hydrochloride (CC-5013 hydrochloride) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide hydrochloride (CC-5013 hydrochloride) specifically inhibits growth of mature B-cell lymphomas, including multiple myeloma, and induces IL-2 release from T cells .

HY-W074850

*Desamino lenalidomide-ethynyl*	Ligands for E3 Ligase	Cancer
Desamino lenalidomide-ethynyl is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. Desamino lenalidomide-ethynyl can be linked to a target protein ligand via a linker to form a PROTAC.

Cat. No.	Product Name

HY-L934

CRBN Ligand Library

118 compounds

CRBN, namely cereblon, is the substrate recognition subunit of the E3 ubiquitin ligase complex in the ubiquitin-proteasome system. A CRBN ligand library refers to a collection of numerous fragments that can specifically bind to the CRBN protein.

These ligands are mostly designed based on validated CRBN-binding warheads and modified through AI-driven molecular generation optimization systems. They not only include classic lenalidomide-derived structures but also cover novel non-lenalidomide scaffolds. After drug-likeness filtering, these ligands exhibit structural diversity and favorable druggable properties. They can be further optimized and modified to facilitate the development of novel molecular glue degraders, accelerate the discovery of molecular glues that induce interactions between CRBN and new substrate proteins, and enable the exploration of novel CRBN substrates for identifying previously unknown CRBN-binding proteins.

MCE compiles 118 fragments that can specifically bind to the CRBN protein, with molecular weights ranging from 200 to 500. Compounds developed based on the library ligands target multiple disease targets such as cancer and autoimmune diseases, further advancing the development of Molecular Glues and PROTACs therapeutic agents.

Cat. No.	Product Name	Target	Research Area

HY-P10899

ETTAC-2	PROTACs TGF-beta/Smad	Endocrinology
ETTAC-2 is a LRG1 PROTAC degrader, degrading LRG1 via the ubiquitin-proteasome pathway with a DC₅₀ value of 8.38 μM. ETTAC-2 penetrates damaged renal cells to reduce the extracellular secretion of LRG1. ETTAC-2 effectively inhibits the TGF-β-Smad3 signaling pathway and diminishes the secretion of fibrosis-associated extracellular matrix proteins. ETTAC-2 degrades LRG1 within fibrotic kidneys and the efficacy in inhibiting the TGF-β-Smad3 pathway both in vitro and vivo. ETTAC-2 can be used for renal fibrosis research .

Cat. No.	Product Name	Target	Research Area	Image

HY-P9965

Elotuzumab HuLuc 63; PDL 063; BMS 901608	Transmembrane Glycoprotein	Cancer
Elotuzumab (HuLuc 63) is an IgG1 monoclonal antibody targeting the SLAMF7 receptor. Elotuzumab exerts antitumor activity by activating natural killer cells and inducing antibody-dependent cell-mediated cytotoxicity. Elotuzumab can be combined with Lenalidomide (HY-A0003), Dexamethasone (HY-14648), etc., for the research of tumors such as multiple myeloma .

Cat. No.	Product Name	Chemical Structure

HY-A0003S

Lenalidomide-d5

Lenalidomide-d₅ is deuterium labeled Lenalidomide. Lenalidomide (CC-5013), a derivative of Thalidomide, acts as molecular glue. Lenalidomide is an orally active immunomodulator. Lenalidomide (CC-5013) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide (CC-5013) specifically inhibits growth of mature B-cell lymphomas, including multiple myeloma, and induces IL-2 release from T cells .

HY-A0003S2

Lenalidomide-13C5,15N

Lenalidomide- ¹³C₅, ¹⁵N is ¹⁵N and ¹³C labeled Lenalidomide (HY-A0003). Lenalidomide (CC-5013), a derivative of Thalidomide, acts as molecular glue. Lenalidomide is an orally active immunomodulator. Lenalidomide (CC-5013) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide (CC-5013) specifically inhibits growth of mature B-cell lymphomas, including multiple myeloma, and induces IL-2 release from T cells .

HY-A0003S3

Lenalidomide-d4

Lenalidomide-d₄ (CC-5013-d₄) is deuterium labeled Lenalidomide. Lenalidomide (CC-5013), a derivative of Thalidomide, acts as molecular glue. Lenalidomide is an orally active immunomodulator. Lenalidomide (CC-5013) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide (CC-5013) specifically inhibits growth of mature B-cell lymphomas, including multiple myeloma, and induces IL-2 release from T cells .

HY-W777286

*rac-Lenalidomide-13C5*
rac Lenalidomide- ¹³C₅ is a ¹³C-labeled rac Lenalidomide .

Cat. No.	Product Name		Classification

HY-129602

SD-36 5+ Cited Publications		PROTAC Synthesis
SD-36 is a potent and efficacious STAT3 PROTAC degrader (K_d=~50 nM), and demonstrates high selectivity over other STAT members. SD-36 also effectively degrades mutated STAT3 proteins in cells and suppresses the transcriptional activity of STAT3 (IC₅₀=10 nM). SD-36 exerts robust anti-tumor activity, and achieves complete and long-lasting tumor regression in mouse tumor models. SD-36 is composed of the STAT3 inhibitor SI-109, a linker, and an analog of Cereblon ligand *Lenalidomide* for E3 ubiquitin ligase . SD-36 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-133139

Lenalidomide-PEG1-azide		PROTAC Synthesis Azide
Lenalidomide-PEG1-azide is a E3 ligase lgand-linker conjugate. Lenalidomide-PEG1-azide incorporates the Lenalidomide based cereblon ligand and a linker.?Lenalidomide-PEG1-azide?can be used to design a PROTAC BRD4 Degrader-2 (HY-133136) . Lenalidomide-PEG1-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-W458035

*Desamino lenalidomide-alkynes*		Alkynes
Desamino lenalidomide-alkynes is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. Desamino lenalidomide-alkynes can be linked to a target protein ligand via a linker to form a PROTAC.

HY-130985

9-Decyn-1-ol		Alkynes PROTAC Synthesis
9-Decyn-1-ol is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. 9-Decyn-1-ol can be used to conjugate GDC-0068 with Lenalidomide to generate INY-03-041. INY-03-041 is a potent, highly selective and PROTAC-based pan-Akt degrader. INY-03-041 inhibits Akt1, Akt2 and Akt3 with IC₅₀s of 2.0 nM, 6.8 nM and 3.5 nM, respectively . 9-Decyn-1-ol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-161131

Lenalidomide 4'-alkyl-C3-azide		Azide
Lenalidomide 4'-alkyl-C3-azide (compound 4a) is a click chemical modified Lenalidomide (HY-A0003) that can be used to synthesize PROTACs. Lenalidomide is an orally active immunomodulator and a ligand for the ubiquitin E3 ligase cereblon (CRBN). Lenalidomide 4'-alkyl-C3-azide contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition reactions (SPAAC) can also occur with molecules containing DBCO or BCN groups .

HY-161132

Lenalidomide 4'-alkyl-C5-azide		Azide
Lenalidomide 4'-alkyl-C5-azide is a functionalized cerebellar ligand for PROTAC development that contains an E3 ligand and an alkyl LC5 ligand with terminal azides that can be coupled to a target protein ligand .

HY-161134

Lenalidomide 4'-PEG2-azide		Azide
Lenalidomide 4'-PEG2-azide is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide 4'-PEG2-azide can be connected to the ligand for protein by a linker to form PROTAC .

HY-161133

Lenalidomide 4'-PEG1-azide		Azide
Lenalidomide 4'-PEG1-azide (Compound 4g) is a lenalidomide-derived azide. Lenalidomide 4'-PEG1-azide incorporates the Lenalidomide based cereblon ligand and a linker. Lenalidomide 4'-PEG1-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups. .

HY-163647

Lenalidomide-COCH-PEG2-azido		Azide
Lenalidomide-COCH-PEG2-azido is a synthesized E3 ligase ligand-linker conjugate that incorporates the Lenalidomide (HY-A0003) based cereblon ligand and a linker. Lenalidomide-COCH-PEG2-azido can be used in the synthesis of PROTAC AKR1C3 degrader-1 (HY-163609) .

HY-175948

Lenalidomide-CO-C3-NH-alkynes		PROTAC Synthesis Alkynes
Lenalidomide-CO-C3-NH-alkynes is an E3 ligase ligand-linker conjugate comprising Lenalidomide (HY-A0003) and a linker. Acepromazine-1-piperazinepropanamine dihydrochloride can be conjugated to a target protein ligand to form a PROTAC molecule—for instance, the PROTAC EGFR degrader 7 (HY-147858) .

HY-163964

Lenalidomide-C3-PEG3-N3		Azide
Lenalidomide-C3-PEG3-N3 is an E3 Ligase Ligand-Linker Conjugate. Lenalidomide-C3-PEG3-N3 can be used to synthesize L18I (HY-163962) .

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