Lenalidomide 5'-piperazine-4-methylpiperidine hydrochloride
Based on 1 Customer Validation
Lenalidomide 5'-piperazine-4-methylpiperidine hydrochloride is a functionalized cerebellar ligand for PROTAC development, combining E3 ligand and terminal piperidine for subsequent chemical reactions. A protein degradant with a rigid connector is generated.
For research use only. We do not sell to patients.
- Purity: 98.57%
- CAS No.: 2520105-60-4
- Formula: C23H33Cl2N5O3
- Molecular Weight:498.45
-
Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Biological Activity
Description
IC50 & Target
|
Cereblon |
Chemical Information
-
CAS No. 2520105-60-4
-
Appearance Solid
-
Molecular Weight 498.45
-
Formula C23H33Cl2N5O3
-
Color White to off-white
-
SMILES
O=C1NC(C(CC1)N2C(C3=CC=C(N4CCN(CC5CCNCC5)CC4)C=C3C2)=O)=O.Cl.Cl
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
DMSO : 25 mg/mL (50.16 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (268 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0062 mL | 10.0311 mL | 20.0622 mL | 50.1555 mL |
| 5 mM | 0.4012 mL | 2.0062 mL | 4.0124 mL | 10.0311 mL | |
| 10 mM | 0.2006 mL | 1.0031 mL | 2.0062 mL | 5.0155 mL | |
| 15 mM | 0.1337 mL | 0.6687 mL | 1.3375 mL | 3.3437 mL | |
| 20 mM | 0.1003 mL | 0.5016 mL | 1.0031 mL | 2.5078 mL | |
| 25 mM | 0.0802 mL | 0.4012 mL | 0.8025 mL | 2.0062 mL | |
| 30 mM | 0.0669 mL | 0.3344 mL | 0.6687 mL | 1.6718 mL | |
| 40 mM | 0.0502 mL | 0.2508 mL | 0.5016 mL | 1.2539 mL | |
| 50 mM | 0.0401 mL | 0.2006 mL | 0.4012 mL | 1.0031 mL |