Pomalidomide-5-C4-NH2 hydrochloride

Cat. No.: HY-155260 Pureza: 98.63%: Ficha de datos
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Pomalidomide-5-C4-NH2 hydrochloride is the Pomalidomide (HY-10984)-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-5-C4-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC.

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Pomalidomide-5-C4-NH2 hydrochloride Estructura química

Tamaño	Stock	Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	En stock	Estimated Time of Arrival: December 31
Solid
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
200 mg	Obtener un presupuesto
500 mg	Obtener un presupuesto

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This product is a controlled substance and not for sale in your territory.

Revisión del cliente

Based on 1 publication(s) in Google Scholar

Other Forms of Pomalidomide-5-C4-NH2 hydrochloride:

Pomalidomide-5-C4-NH2 Obtener un presupuesto

Recomendaciones destacadas

•Related Small Molecules:

•Related Proteins:

Ver todos los productos específicos de isoformas E3 Ligase Ligand-Linker Conjugates:

Ver todas las isoformas

von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

Actividad biológica
Pureza y Documentación
Referencias
Revisión del cliente

Descripciòn

Peso molecular

380.83

Fòrmula

C₁₇H₂₁ClN₄O₄

Appearance

Solid

Color

Light yellow to green yellow

SMILES

O=C1C(C=CC(NCCCCN)=C2)=C2C(N1C(CC3)C(NC3=O)=O)=O.Cl

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvente y solubilidad

In Vitro:

DMSO : 100 mg/mL (262.58 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6258 mL	13.1292 mL	26.2584 mL
5 mM	0.5252 mL	2.6258 mL	5.2517 mL
10 mM	0.2626 mL	1.3129 mL	2.6258 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Pureza y Documentación

Purity: 98.63%

Select Batch:

Ficha de datos (266 KB) SDS (252 KB)

COA (246 KB) HNMR (143 KB) RP-HPLC (172 KB) LCMS (110 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6258 mL	13.1292 mL	26.2584 mL	65.6461 mL
	5 mM	0.5252 mL	2.6258 mL	5.2517 mL	13.1292 mL
	10 mM	0.2626 mL	1.3129 mL	2.6258 mL	6.5646 mL
	15 mM	0.1751 mL	0.8753 mL	1.7506 mL	4.3764 mL
	20 mM	0.1313 mL	0.6565 mL	1.3129 mL	3.2823 mL
	25 mM	0.1050 mL	0.5252 mL	1.0503 mL	2.6258 mL
	30 mM	0.0875 mL	0.4376 mL	0.8753 mL	2.1882 mL
	40 mM	0.0656 mL	0.3282 mL	0.6565 mL	1.6412 mL
	50 mM	0.0525 mL	0.2626 mL	0.5252 mL	1.3129 mL
	60 mM	0.0438 mL	0.2188 mL	0.4376 mL	1.0941 mL
	80 mM	0.0328 mL	0.1641 mL	0.3282 mL	0.8206 mL
	100 mM	0.0263 mL	0.1313 mL	0.2626 mL	0.6565 mL