Desamino lenalidomide-6-OH
Based on 1 Customer Validation
Desamino lenalidomide-6-OH is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. Desamino lenalidomide-6-OH can be linked to a target protein ligand via a linker to form a PROTAC.
For research use only. We do not sell to patients.
- Purity: 99.36%
- CAS No.: 1416990-09-4
- Formula: C13H12N2O4
- Molecular Weight:260.25
-
Storage:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
-
Help & FAQs
-
Bioactive Compound Library Max
HY-L181
-
Bioactive Compound Library
HY-L001
-
Ubiquitination Compound Library
HY-L050
-
E3 Ligase Ligand Library
HY-L128
-
MCE Bioactive Compound Library
HY-L001V
-
High-Throughput Bioactive Compound Library
HY-L205
-
3D Diverse Fragment Library
HY-L903
-
MCE Kinase Hinge Binder Fragment Library
HY-L907
-
Molecular Glue-like Compound Library
HY-L918
Biological Activity
|
Cereblon |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| NAMALVA | IC50 |
>1 μM
Compound: 13
|
Antiproliferative activity against human NAMALWA cells assessed as inhibition of [3H]thymidine incorporation after 72 hrs by scintillation counting
Antiproliferative activity against human NAMALWA cells assessed as inhibition of [3H]thymidine incorporation after 72 hrs by scintillation counting
|
[PMID: 23168019] |
| PBMC | IC50 |
>1 μM
Compound: 13
|
Inhibition of TNF-alpha production in LPS-stimulated human PBMC preincubated for 1 hr before LPS challenge measured after 28 to 20 hrs by ELISA
Inhibition of TNF-alpha production in LPS-stimulated human PBMC preincubated for 1 hr before LPS challenge measured after 28 to 20 hrs by ELISA
|
[PMID: 23168019] |
| T-cell | EC50 |
>1 μM
Compound: 13
|
Inhibition of IL-2 production in human T cells measured after 2 to 3 days by ELISA
Inhibition of IL-2 production in human T cells measured after 2 to 3 days by ELISA
|
[PMID: 23168019] |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 1416990-09-4
-
Appearance Solid
-
Molecular Weight 260.25
-
Formula C13H12N2O4
-
Color Yellow to brown
-
SMILES
O=C1NC(=O)C(N2C(=O)C3=CC(O)=CC=C3C2)CC1
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
DMSO : 25 mg/mL (96.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (243 KB)
-
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
-
Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.8425 mL | 19.2123 mL | 38.4246 mL | 96.0615 mL |
| 5 mM | 0.7685 mL | 3.8425 mL | 7.6849 mL | 19.2123 mL | |
| 10 mM | 0.3842 mL | 1.9212 mL | 3.8425 mL | 9.6061 mL | |
| 15 mM | 0.2562 mL | 1.2808 mL | 2.5616 mL | 6.4041 mL | |
| 20 mM | 0.1921 mL | 0.9606 mL | 1.9212 mL | 4.8031 mL | |
| 25 mM | 0.1537 mL | 0.7685 mL | 1.5370 mL | 3.8425 mL | |
| 30 mM | 0.1281 mL | 0.6404 mL | 1.2808 mL | 3.2020 mL | |
| 40 mM | 0.0961 mL | 0.4803 mL | 0.9606 mL | 2.4015 mL | |
| 50 mM | 0.0768 mL | 0.3842 mL | 0.7685 mL | 1.9212 mL | |
| 60 mM | 0.0640 mL | 0.3202 mL | 0.6404 mL | 1.6010 mL | |
| 80 mM | 0.0480 mL | 0.2402 mL | 0.4803 mL | 1.2008 mL |
Desamino lenalidomide-6-OH Related Classifications
HY-W251343 Related Classifications
Powered by Bioz