1. PROTAC
  2. Ligand for Target Protein for PROTAC
  3. Ipatasertib-NH2

Ipatasertib-NH2 (Synonyms: GDC-0068-NH2; RG7440-NH2)

Cat. No.: HY-130988
Handling Instructions

Ipatasertib-NH2 (GDC-0068-NH2;RG7440-NH2) is a ligand for target protein AKT for PROTAC, binds to lenalidomide, a ligand of ubiquitin E3 ligase cereblon (CRBN), via a ten-hydrocarbon linker to form INY-03-041 (HY-133120) to degrade AKT.

For research use only. We do not sell to patients.

Ipatasertib-NH2 Chemical Structure

Ipatasertib-NH2 Chemical Structure

CAS No. : 1001382-14-4

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Description

Ipatasertib-NH2 (GDC-0068-NH2;RG7440-NH2) is a ligand for target protein AKT for PROTAC, binds to lenalidomide, a ligand of ubiquitin E3 ligase cereblon (CRBN), via a ten-hydrocarbon linker to form INY-03-041 (HY-133120) to degrade AKT[1].

IC50 & Target

AKT[1]

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Molecular Weight

415.92

Formula

C₂₁H₂₆ClN₅O₂

CAS No.

1001382-14-4

SMILES

O=C(N1CCN(C2=C([[email protected]](C)C[[email protected]]3O)C3=NC=N2)CC1)[[email protected]@H](C4=CC=C(Cl)C=C4)CN

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Ipatasertib-NH2GDC-0068-NH2RG7440-NH2Ligand for Target Protein for PROTACTarget Protein-binding MoietyGDC-0068IpatasertibAKTlenalidomidePROTACINY-03-041Inhibitorinhibitorinhibit

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Ipatasertib-NH2
Cat. No.:
HY-130988
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