Ipatasertib-NH2 dihydrochloride (Synonyms: GDC-0068-NH2 dihydrochloride; RG7440-NH2 dihydrochloride)

Cat. No.: HY-130988A: FAQs
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Ipatasertib-NH2 dihydrochloride is a ligand for target protein AKT for PROTAC (INY-03-041). INY-03-041 is composed of Ipatasertib-NH2, a ten-hydrocarbon linker, and a CRBN ligand Lenalidomide for E3 ubiquitin ligase.

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Ipatasertib-NH2 dihydrochloride Chemical Structure

CAS No. : 1001264-73-8

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Other In-stock Forms of Ipatasertib-NH2 dihydrochloride:

Ipatasertib-NH2

Other Forms of Ipatasertib-NH2 dihydrochloride:

Ipatasertib-NH2 In-stock

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Description	Ipatasertib-NH2 dihydrochloride is a ligand for target protein AKT for PROTAC (INY-03-041). INY-03-041 is composed of Ipatasertib-NH2, a ten-hydrocarbon linker, and a CRBN ligand Lenalidomide for E3 ubiquitin ligase^[1].
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Ipatasertib-NH2 dihydrochloride Related Antibodies
Molecular Weight	488.84
Formula	C₂₁H₂₈Cl₃N₅O₂
CAS No.	1001264-73-8
SMILES	C[C@H]1C2=C(N3CCN(CC3)C([C@@H](C4=CC=C(C=C4)Cl)CN)=O)N=CN=C2[C@@H](C1)O.Cl.Cl
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (271 KB) Handling Instructions (2659 KB)
References	[1]. You I, et al. Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling. Cell Chem Biol. 2020 Jan 16;27(1):66-73.e7. [Content Brief]

Ipatasertib-NH2 dihydrochloride Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ipatasertib-NH21001264-73-8GDC-0068-NH2RG7440-NH2Ligands for Target Protein for PROTACTarget Protein-binding MoietyGDC-0068IpatasertibAKTlenalidomidePROTACINY-03-041Inhibitorinhibitorinhibit

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Ipatasertib-NH2 dihydrochloride (Synonyms: GDC-0068-NH2 dihydrochloride; RG7440-NH2 dihydrochloride)

Other Forms of Ipatasertib-NH2 dihydrochloride:

Ipatasertib-NH2 dihydrochloride Related Antibodies

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

Biological Activity

Purity & Documentation

References

Customer Review