1. PROTAC
  2. Ligand for Target Protein for PROTAC
  3. Ipatasertib-NH2 dihydrochloride

Ipatasertib-NH2 dihydrochloride (Synonyms: GDC-0068-NH2 dihydrochloride; RG7440-NH2 dihydrochloride)

Cat. No.: HY-130988A
Handling Instructions

Ipatasertib-NH2 dihydrochloride is a ligand for target protein AKT for PROTAC (INY-03-041). INY-03-041 is composed of Ipatasertib-NH2, a ten-hydrocarbon linker, and a CRBN ligand Lenalidomide for E3 ubiquitin ligase.

For research use only. We do not sell to patients.

Ipatasertib-NH2 dihydrochloride Chemical Structure

Ipatasertib-NH2 dihydrochloride Chemical Structure

CAS No. : 1001264-73-8

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Description

Ipatasertib-NH2 dihydrochloride is a ligand for target protein AKT for PROTAC (INY-03-041). INY-03-041 is composed of Ipatasertib-NH2, a ten-hydrocarbon linker, and a CRBN ligand Lenalidomide for E3 ubiquitin ligase[1].

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

488.84

Formula

C₂₁H₂₈Cl₃N₅O₂

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
Ipatasertib-NH2 dihydrochloride
Cat. No.:
HY-130988A
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