Desamino lenalidomide-7-F
Based on 1 Customer Validation
Desamino lenalidomide-7-F is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. Desamino lenalidomide-7-F can be linked to a target protein ligand via a linker to form a PROTAC.
For research use only. We do not sell to patients.
- Purity : ≥98.0%
- CAS No.: 2287267-33-6
- Formula: C13H11FN2O3
- Molecular Weight:262.24
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Help & FAQs
Biological Activity
Description
IC50 & Target
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Cereblon |
In Vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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CAS No. 2287267-33-6
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Appearance Solid
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Molecular Weight 262.24
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Formula C13H11FN2O3
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Color Light yellow to yellow
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SMILES
O=C1NC(=O)C(N2C(=O)C=3C(F)=CC=CC3C2)CC1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 25 mg/mL (95.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (244 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.8133 mL | 19.0665 mL | 38.1330 mL | 95.3325 mL |
| 5 mM | 0.7627 mL | 3.8133 mL | 7.6266 mL | 19.0665 mL | |
| 10 mM | 0.3813 mL | 1.9067 mL | 3.8133 mL | 9.5333 mL | |
| 15 mM | 0.2542 mL | 1.2711 mL | 2.5422 mL | 6.3555 mL | |
| 20 mM | 0.1907 mL | 0.9533 mL | 1.9067 mL | 4.7666 mL | |
| 25 mM | 0.1525 mL | 0.7627 mL | 1.5253 mL | 3.8133 mL | |
| 30 mM | 0.1271 mL | 0.6356 mL | 1.2711 mL | 3.1778 mL | |
| 40 mM | 0.0953 mL | 0.4767 mL | 0.9533 mL | 2.3833 mL | |
| 50 mM | 0.0763 mL | 0.3813 mL | 0.7627 mL | 1.9067 mL | |
| 60 mM | 0.0636 mL | 0.3178 mL | 0.6356 mL | 1.5889 mL | |
| 80 mM | 0.0477 mL | 0.2383 mL | 0.4767 mL | 1.1917 mL |
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