Desamino lenalidomide-5-COOH

Cat. No.: HY-W586325 Purity: 99.01%: Data Sheet
COA

SDS
Handling Instructions
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Desamino lenalidomide-5-COOH is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. Desamino lenalidomide-5-COOH can be linked to a target protein ligand via a linker to form a PROTAC.

For research use only. We do not sell to patients.

Desamino lenalidomide-5-COOH Chemical Structure

CAS No. : 2171519-15-4

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Ligands for E3 Ligase Isoform Specific Products:

View All Isoforms

von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1 TRIM21 NEURL1B

Biological Activity
Purity & Documentation
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Description

IC₅₀ & Target

Cereblon

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

288.26

Formula

C₁₄H₁₂N₂O₅

CAS No.

2171519-15-4

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)C1=CC=C2C(=C1)C(=O)N(C2)C3C(=O)NC(=O)CC3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature 3 years

In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : 12.5 mg/mL (43.36 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.4691 mL	17.3455 mL	34.6909 mL
5 mM	0.6938 mL	3.4691 mL	6.9382 mL
10 mM	0.3469 mL	1.7345 mL	3.4691 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.01%

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Data Sheet (243 KB) SDS (393 KB)

COA (247 KB) HNMR (261 KB) LCMS (331 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.4691 mL	17.3455 mL	34.6909 mL	86.7273 mL
	5 mM	0.6938 mL	3.4691 mL	6.9382 mL	17.3455 mL
	10 mM	0.3469 mL	1.7345 mL	3.4691 mL	8.6727 mL
	15 mM	0.2313 mL	1.1564 mL	2.3127 mL	5.7818 mL
	20 mM	0.1735 mL	0.8673 mL	1.7345 mL	4.3364 mL
	25 mM	0.1388 mL	0.6938 mL	1.3876 mL	3.4691 mL
	30 mM	0.1156 mL	0.5782 mL	1.1564 mL	2.8909 mL
	40 mM	0.0867 mL	0.4336 mL	0.8673 mL	2.1682 mL