Desamino lenalidomide-5-F

Cat. No.: HY-132226 Pureza: 97.72%: Ficha de datos
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Desamino lenalidomide-5-F is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. Desamino lenalidomide-5-F can be linked to a target protein ligand via a linker to form a PROTAC.

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Desamino lenalidomide-5-F Estructura química

No. CAS : 2468780-76-7

Tamaño	Stock	Cantidad

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	En stock	Estimated Time of Arrival: December 31
Solid
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
250 mg	En stock	Estimated Time of Arrival: December 31
500 mg	En stock	Estimated Time of Arrival: December 31
1 g	En stock	Estimated Time of Arrival: December 31
5 g	En stock	Estimated Time of Arrival: December 31
10 g	En stock	Estimated Time of Arrival: December 31
50 g	Obtener un presupuesto

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Recomendaciones destacadas

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Ver todos los productos específicos de isoformas Ligands for E3 Ligase:

Ver todas las isoformas

von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1 TRIM21 NEURL1B KLHL41

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Descripciòn

IC₅₀ & Target

Cereblon

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Peso molecular

262.24

Fòrmula

C₁₃H₁₁FN₂O₃

No. CAS

2468780-76-7

Appearance

Solid

Color

Off-white to light brown

SMILES

O=C1NC(=O)C(N2C(=O)C3=CC=C(F)C=C3C2)CC1

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Store at room temperature 3 years

In solvent	-80°C	2 years
	-20°C	1 year

Solvente y solubilidad

In Vitro:

DMSO : 5.83 mg/mL (22.23 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.8133 mL	19.0665 mL	38.1330 mL
5 mM	0.7627 mL	3.8133 mL	7.6266 mL
10 mM	0.3813 mL	1.9067 mL	3.8133 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Pureza y Documentación

Purity: 97.72%

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Ficha de datos (243 KB) SDS (394 KB)

COA (247 KB) HNMR (268 KB) LCMS (103 KB)

Instrucciones de manejo (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.8133 mL	19.0665 mL	38.1330 mL	95.3325 mL
	5 mM	0.7627 mL	3.8133 mL	7.6266 mL	19.0665 mL
	10 mM	0.3813 mL	1.9067 mL	3.8133 mL	9.5333 mL
	15 mM	0.2542 mL	1.2711 mL	2.5422 mL	6.3555 mL
	20 mM	0.1907 mL	0.9533 mL	1.9067 mL	4.7666 mL