PROTAC BRD4 Degrader-32
PROTAC BRD4 Degrader-32 (Compound 22) is a BRD4 PROTAC degrader (DC50: 0.20 nM). PROTAC BRD4 Degrader-32 connects the BRD4-binding domain and CRBN-binding domain through a unique carbon-carbon linked linker to form a ternary complex, inducing ubiquitination of BRD4 for proteasomal degradation. PROTAC BRD4 Degrader-32 is promising for research of BRD4-related cancers (such as hematological malignancies).
(Pink: BRD4 ligand (HY-13960); Blue: Cereblon ligand (HY-W072954); Black: linker (HY-176450)).
For research use only. We do not sell to patients.
- Formula: C42H42ClN5O5
- Molecular Weight:732.27
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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- References
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Biological Activity
Chemical Information
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Molecular Weight 732.27
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Formula C42H42ClN5O5
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SMILES
ClC1=CC=C(N[C@@H]2C[C@H](C)N(C(C)=O)C3=C2C=C(C4=CC=C(C(NCCCCC5=CC=C6C(CN(C(CCC(N7)=O)C7=O)C6=O)=C5)=O)C=C4)C=C3)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PROTAC BRD4 Degrader-32 Related Classifications
HY-176449 Related Classifications
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