Desamino lenalidomide-7-OH

Cat. No.: HY-W458077 Purity: 99.11%: Data Sheet
COA

SDS
Handling Instructions
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Desamino lenalidomide-7-OH is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. Desamino lenalidomide-7-OH can be linked to a target protein ligand via a linker to form a PROTAC.

For research use only. We do not sell to patients.

Desamino lenalidomide-7-OH Chemical Structure

CAS No. : 1416990-10-7

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
250 mg	In-stock	Estimated Time of Arrival: December 31
500 mg	In-stock	Estimated Time of Arrival: December 31
1 g	In-stock	Estimated Time of Arrival: December 31
5 g	Get quote
10 g	Get quote

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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Ligands for E3 Ligase Isoform Specific Products:

View All Isoforms

von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1 TRIM21 NEURL1B

Biological Activity
Purity & Documentation
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Description

IC₅₀ & Target

Cereblon

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

260.25

Formula

C₁₃H₁₂N₂O₄

CAS No.

1416990-10-7

Appearance

Solid

Color

Light blue to blue

SMILES

O=C1NC(=O)C(N2C(=O)C=3C(O)=CC=CC3C2)CC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (384.25 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.8425 mL	19.2123 mL	38.4246 mL
5 mM	0.7685 mL	3.8425 mL	7.6849 mL
10 mM	0.3842 mL	1.9212 mL	3.8425 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.11%

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Data Sheet (245 KB) SDS (393 KB)

COA (251 KB) HNMR (135 KB) RP-HPLC (222 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.8425 mL	19.2123 mL	38.4246 mL	96.0615 mL
	5 mM	0.7685 mL	3.8425 mL	7.6849 mL	19.2123 mL
	10 mM	0.3842 mL	1.9212 mL	3.8425 mL	9.6061 mL
	15 mM	0.2562 mL	1.2808 mL	2.5616 mL	6.4041 mL
	20 mM	0.1921 mL	0.9606 mL	1.9212 mL	4.8031 mL
	25 mM	0.1537 mL	0.7685 mL	1.5370 mL	3.8425 mL
	30 mM	0.1281 mL	0.6404 mL	1.2808 mL	3.2020 mL
	40 mM	0.0961 mL	0.4803 mL	0.9606 mL	2.4015 mL
	50 mM	0.0768 mL	0.3842 mL	0.7685 mL	1.9212 mL
	60 mM	0.0640 mL	0.3202 mL	0.6404 mL	1.6010 mL
	80 mM	0.0480 mL	0.2402 mL	0.4803 mL	1.2008 mL
	100 mM	0.0384 mL	0.1921 mL	0.3842 mL	0.9606 mL