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  3. 9-Decyn-1-ol

9-Decyn-1-ol 

Cat. No.: HY-130985
Handling Instructions

9-Decyn-1-ol is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. 9-Decyn-1-ol can be used to conjugate GDC-0068 with Lenalidomide to generate INY-03-041. INY-03-041 is a potent, highly selective and PROTAC-based pan-Akt degrader. INY-03-041 inhibits Akt1, Akt2 and Akt3 with IC50s of 2.0 nM, 6.8 nM and 3.5 nM, respectively.

For research use only. We do not sell to patients.

9-Decyn-1-ol Chemical Structure

9-Decyn-1-ol Chemical Structure

CAS No. : 17643-36-6

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Description

9-Decyn-1-ol is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. 9-Decyn-1-ol can be used to conjugate GDC-0068 with Lenalidomide to generate INY-03-041. INY-03-041 is a potent, highly selective and PROTAC-based pan-Akt degrader. INY-03-041 inhibits Akt1, Akt2 and Akt3 with IC50s of 2.0 nM, 6.8 nM and 3.5 nM, respectively[1].

IC50 & Target[1]

Alkyl/ether

 

In Vitro

9-Decyn-1-ol can be used to conjugate GDC-0068 with Lenalidomide to generate INY-03-041. INY-03-041 is a pan-AKT degrader consisting of the ATP-competitive AKT inhibitor GDC-0068 conjugated to Lenalidomide by a linker[1].

Molecular Weight

154.25

Formula

C₁₀H₁₈O

CAS No.

17643-36-6

SMILES

C#CCCCCCCCCO

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

9-Decyn-1-olPROTAC LinkeralkyletherGDC-0068LenalidomideINY-03-041AktdegraderInhibitorinhibitorinhibit

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9-Decyn-1-ol
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