Desamino lenalidomide-pinacolborane

Cat. No.: HY-W244728 Purity: 98.0%: Data Sheet
COA

SDS
Handling Instructions
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Desamino lenalidomide-pinacolborane is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. Desamino lenalidomide-pinacolborane can be linked to a target protein ligand via a linker to form a PROTAC.

For research use only. We do not sell to patients.

Desamino lenalidomide-pinacolborane Chemical Structure

CAS No. : 2291363-98-7

Size	Stock	Quantity
100 mg	In-stock	Estimated Time of Arrival: December 31
250 mg	In-stock	Estimated Time of Arrival: December 31
500 mg	In-stock	Estimated Time of Arrival: December 31
1 g	In-stock	Estimated Time of Arrival: December 31
5 g	In-stock	Estimated Time of Arrival: December 31
10 g	Get quote
50 g	Get quote

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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Ligands for E3 Ligase Isoform Specific Products:

View All Isoforms

von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1 TRIM21 NEURL1B

Biological Activity
Purity & Documentation
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Description

IC₅₀ & Target

Cereblon

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

370.21

Formula

C₁₉H₂₃BN₂O₅

CAS No.

2291363-98-7

Appearance

Solid

Color

Light brown to gray

SMILES

O=C1C2=CC=C(C=C2CN1C3C(=O)NC(=O)CC3)B4OC(C)(C)C(O4)(C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 4 mg/mL (10.80 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7012 mL	13.5058 mL	27.0117 mL
5 mM	0.5402 mL	2.7012 mL	5.4023 mL
10 mM	0.2701 mL	1.3506 mL	2.7012 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.0%

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Data Sheet (243 KB) SDS (393 KB)

COA (250 KB) HNMR (122 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.7012 mL	13.5058 mL	27.0117 mL	67.5292 mL
	5 mM	0.5402 mL	2.7012 mL	5.4023 mL	13.5058 mL
	10 mM	0.2701 mL	1.3506 mL	2.7012 mL	6.7529 mL