Desamino lenalidomide-5-acetonitrile

製品番号: HY-W244820 純度: 99.56%: Data Sheet SDS COA 取扱説明書
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Desamino lenalidomide-5-acetonitrile is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. Desamino lenalidomide-5-acetonitrile can be linked to a target protein ligand via a linker to form a PROTAC.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Desamino lenalidomide-5-acetonitrile 構造式

CAS 番号 : 1010100-27-2

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 143	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 143	在庫あり	Estimated Time of Arrival: December 31
Solid
100 mg	$130	在庫あり	Estimated Time of Arrival: December 31
250 mg	$260	お問い合わせ
500 mg	$415	お問い合わせ
1 g	$665	お問い合わせ
5 g		お問い合わせ
10 g		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

Ligands for E3 Ligase アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1 TRIM21 NEURL1B

生物活性
純度とドキュメンテーション
カスタマーレビュー

製品説明

IC₅₀ & Target

Cereblon

体外実験

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

269.26

分子式

C₁₄H₁₁N₃O₃

CAS 番号

1010100-27-2

Appearance

Solid

Color

White to off-white

SMILES

N#CC1=CC=C2C(N(C3C(NC(CC3)=O)=O)CC2=C1)=O

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : 4.17 mg/mL (15.49 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.7139 mL	18.5694 mL	37.1388 mL
5 mM	0.7428 mL	3.7139 mL	7.4278 mL
10 mM	0.3714 mL	1.8569 mL	3.7139 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 99.56%

Select Batch:

データシート (243 KB) SDS (393 KB)

COA (247 KB) HNMR (259 KB) LCMS (93 KB)

取扱説明書 (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.7139 mL	18.5694 mL	37.1388 mL	92.8471 mL
	5 mM	0.7428 mL	3.7139 mL	7.4278 mL	18.5694 mL
	10 mM	0.3714 mL	1.8569 mL	3.7139 mL	9.2847 mL
	15 mM	0.2476 mL	1.2380 mL	2.4759 mL	6.1898 mL