Desamino lenalidomide-5-acetonitrile

Cat. No.: HY-W244820 Pureza: 99.56%: Ficha de datos
COA

SDS
Instrucciones de manejo
FAQs
Technical Support

Desamino lenalidomide-5-acetonitrile is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. Desamino lenalidomide-5-acetonitrile can be linked to a target protein ligand via a linker to form a PROTAC.

Para uso exclusivo en investigación. No vendemos a pacientes.

Desamino lenalidomide-5-acetonitrile Estructura química

No. CAS : 1010100-27-2

Tamaño	Stock	Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	En stock	Estimated Time of Arrival: December 31
Solid
100 mg	En stock	Estimated Time of Arrival: December 31
250 mg	Obtener un presupuesto	Estimated Time of Arrival: December 31
500 mg	Obtener un presupuesto	Estimated Time of Arrival: December 31
1 g	Obtener un presupuesto	Estimated Time of Arrival: December 31
5 g	Obtener un presupuesto
10 g	Obtener un presupuesto

or Consulta para venta a granel

* Seleccione Cantidad antes de agregar artículos.

This product is a controlled substance and not for sale in your territory.

Recomendaciones destacadas

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Ver todos los productos específicos de isoformas Ligands for E3 Ligase:

Ver todas las isoformas

von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1 TRIM21 NEURL1B

Actividad biológica
Pureza y Documentación
Revisión del cliente

Descripciòn

IC₅₀ & Target

Cereblon

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Peso molecular

269.26

Fòrmula

C₁₄H₁₁N₃O₃

No. CAS

1010100-27-2

Appearance

Solid

Color

White to off-white

SMILES

N#CC1=CC=C2C(N(C3C(NC(CC3)=O)=O)CC2=C1)=O

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvente y solubilidad

In Vitro:

DMSO : 4.17 mg/mL (15.49 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.7139 mL	18.5694 mL	37.1388 mL
5 mM	0.7428 mL	3.7139 mL	7.4278 mL
10 mM	0.3714 mL	1.8569 mL	3.7139 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Pureza y Documentación

Purity: 99.56%

Select Batch:

Ficha de datos (243 KB) SDS (393 KB)

COA (247 KB) HNMR (259 KB) LCMS (93 KB)

Instrucciones de manejo (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.7139 mL	18.5694 mL	37.1388 mL	92.8471 mL
	5 mM	0.7428 mL	3.7139 mL	7.4278 mL	18.5694 mL
	10 mM	0.3714 mL	1.8569 mL	3.7139 mL	9.2847 mL
	15 mM	0.2476 mL	1.2380 mL	2.4759 mL	6.1898 mL