Lenalidomide-PEG1-azide
Based on 1 Customer Validation
Lenalidomide-PEG1-azide is a cereblon (CRBN)-recruiting azide-functionalized Lenalidomide (HY-A0003) derivative with a PEG1 linker, serving as a building block for synthesis of soluble epoxide hydrolase (sEH) PROTACs.Lenalidomide-PEG1-azide lacks definitive identity or significant scientific classification in associated literature.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 95.84%
- CAS 番号: 2185795-67-7
- 分子式: C17H18N6O5
- 分子量:386.36
-
保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
-
溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
E3 Ligase Ligand-Linker Conjugates アイソフォーム固有の製品をすべて表示
More
生物活性
製品説明
IC50 & Target
[1]|
Cereblon |
体外実験
Soluble epoxide hydrolases (sEHs) are key hydrolases involved in the metabolism of epoxide fatty acids. They catalyze the hydrolysis of biologically active epoxide fatty acids into inactive dihydroxy compounds, regulating physiological processes such as vasodilation, inflammation, and pain. They are research targets for cardiovascular protection and pain management. Azide functionalization of molecules involves introducing azido groups (-N3) at specific positions in organic molecules through chemical synthesis. Azide groups possess unique chemical properties and high biological inertness, enabling them to undergo highly efficient and specific azido-alkyne cycloaddition reactions (CuAAC click chemistry) with terminal alkynes under copper catalysis. These reactions are widely used in drug conjugate synthesis, bioprobe labeling, and material functionalization.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
化学情報
-
CAS 番号 2185795-67-7
-
性状 Solid
-
分子量 386.36
-
分子式 C17H18N6O5
-
Color Off-white to light yellow
-
SMILES
O=C(NC1=CC=CC2=C1CN(C(CC3)C(NC3=O)=O)C2=O)COCCN=[N+]=[N-]
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
DMSO : 100 mg/mL (258.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
-
データシート (280 KB)
-
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
-
取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5883 mL | 12.9413 mL | 25.8826 mL | 64.7065 mL |
| 5 mM | 0.5177 mL | 2.5883 mL | 5.1765 mL | 12.9413 mL | |
| 10 mM | 0.2588 mL | 1.2941 mL | 2.5883 mL | 6.4706 mL | |
| 15 mM | 0.1726 mL | 0.8628 mL | 1.7255 mL | 4.3138 mL | |
| 20 mM | 0.1294 mL | 0.6471 mL | 1.2941 mL | 3.2353 mL | |
| 25 mM | 0.1035 mL | 0.5177 mL | 1.0353 mL | 2.5883 mL | |
| 30 mM | 0.0863 mL | 0.4314 mL | 0.8628 mL | 2.1569 mL | |
| 40 mM | 0.0647 mL | 0.3235 mL | 0.6471 mL | 1.6177 mL | |
| 50 mM | 0.0518 mL | 0.2588 mL | 0.5177 mL | 1.2941 mL | |
| 60 mM | 0.0431 mL | 0.2157 mL | 0.4314 mL | 1.0784 mL | |
| 80 mM | 0.0324 mL | 0.1618 mL | 0.3235 mL | 0.8088 mL | |
| 100 mM | 0.0259 mL | 0.1294 mL | 0.2588 mL | 0.6471 mL |
Lenalidomide-PEG1-azide 関連分類
HY-133139 関連分類
Powered by Bioz