Lenalidomide-PEG1-azide
Based on 1 Customer Validation
Lenalidomide-PEG1-azide is a cereblon (CRBN)-recruiting azide-functionalized Lenalidomide (HY-A0003) derivative with a PEG1 linker, serving as a building block for synthesis of soluble epoxide hydrolase (sEH) PROTACs.Lenalidomide-PEG1-azide lacks definitive identity or significant scientific classification in associated literature.
For research use only. We do not sell to patients.
- Purity : 95.84%
- CAS No.: 2185795-67-7
- Formula: C17H18N6O5
- Molecular Weight:386.36
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All E3 Ligase Ligand-Linker Conjugates Isoforms
More
Biological Activity
Description
IC50 & Target
[1]|
Cereblon |
In Vitro
Soluble epoxide hydrolases (sEHs) are key hydrolases involved in the metabolism of epoxide fatty acids. They catalyze the hydrolysis of biologically active epoxide fatty acids into inactive dihydroxy compounds, regulating physiological processes such as vasodilation, inflammation, and pain. They are research targets for cardiovascular protection and pain management. Azide functionalization of molecules involves introducing azido groups (-N3) at specific positions in organic molecules through chemical synthesis. Azide groups possess unique chemical properties and high biological inertness, enabling them to undergo highly efficient and specific azido-alkyne cycloaddition reactions (CuAAC click chemistry) with terminal alkynes under copper catalysis. These reactions are widely used in drug conjugate synthesis, bioprobe labeling, and material functionalization.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2185795-67-7
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Appearance Solid
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Molecular Weight 386.36
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Formula C17H18N6O5
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Color Off-white to light yellow
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SMILES
O=C(NC1=CC=CC2=C1CN(C(CC3)C(NC3=O)=O)C2=O)COCCN=[N+]=[N-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (258.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (280 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5883 mL | 12.9413 mL | 25.8826 mL | 64.7065 mL |
| 5 mM | 0.5177 mL | 2.5883 mL | 5.1765 mL | 12.9413 mL | |
| 10 mM | 0.2588 mL | 1.2941 mL | 2.5883 mL | 6.4706 mL | |
| 15 mM | 0.1726 mL | 0.8628 mL | 1.7255 mL | 4.3138 mL | |
| 20 mM | 0.1294 mL | 0.6471 mL | 1.2941 mL | 3.2353 mL | |
| 25 mM | 0.1035 mL | 0.5177 mL | 1.0353 mL | 2.5883 mL | |
| 30 mM | 0.0863 mL | 0.4314 mL | 0.8628 mL | 2.1569 mL | |
| 40 mM | 0.0647 mL | 0.3235 mL | 0.6471 mL | 1.6177 mL | |
| 50 mM | 0.0518 mL | 0.2588 mL | 0.5177 mL | 1.2941 mL | |
| 60 mM | 0.0431 mL | 0.2157 mL | 0.4314 mL | 1.0784 mL | |
| 80 mM | 0.0324 mL | 0.1618 mL | 0.3235 mL | 0.8088 mL | |
| 100 mM | 0.0259 mL | 0.1294 mL | 0.2588 mL | 0.6471 mL |
Lenalidomide-PEG1-azide Related Classifications
HY-133139 Related Classifications
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