2. PROTAC
  3. Ligands for E3 Ligase
  4. Desamino lenalidomide-cyano

Desamino lenalidomide-cyano is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. Desamino lenalidomide-cyano can be linked to a target protein ligand via a linker to form a PROTAC.

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Desamino lenalidomide-cyano

Desamino lenalidomide-cyano Chemical Structure

CAS No. : 2639386-82-4

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Desamino lenalidomide-cyano Related Antibodies

Top Publications Citing Use of Products

View All Ligands for E3 Ligase Isoform Specific Products:

View All Isoforms
von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1 TRIM21 NEURL1B

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Description

Desamino lenalidomide-cyano is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. Desamino lenalidomide-cyano can be linked to a target protein ligand via a linker to form a PROTAC.

IC50 & Target

Cereblon

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Desamino lenalidomide-cyano Related Antibodies
Molecular Weight

269.26

Formula

C14H11N3O3
CAS No.
Appearance

Solid

SMILES

N#CC1=CC=C2C(=C1)C(=O)N(C2)C3C(=O)NC(=O)CC3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Store at room temperature 3 years

In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 6.67 mg/mL (24.77 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7139 mL 18.5694 mL 37.1388 mL
5 mM 0.7428 mL 3.7139 mL 7.4278 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.91%

SDS (393 KB)

COA (247 KB) HNMR (133 KB) RP-HPLC (225 KB) LCMS (331 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.7139 mL 18.5694 mL 37.1388 mL 92.8471 mL
5 mM 0.7428 mL 3.7139 mL 7.4278 mL 18.5694 mL
10 mM 0.3714 mL 1.8569 mL 3.7139 mL 9.2847 mL
15 mM 0.2476 mL 1.2380 mL 2.4759 mL 6.1898 mL
20 mM 0.1857 mL 0.9285 mL 1.8569 mL 4.6424 mL
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Desamino lenalidomide-cyano Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Desamino lenalidomide-cyano2639386-82-4Ligands for E3 LigaseE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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