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Sulfo

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Linker (28) ADC Payload (1) Antibody-Drug Conjugates (ADCs) (4) Antifolate (1) Apoptosis (1) Bacterial (1) Biochemical Assay Reagents (32) CCR (1) Dipeptidyl Peptidase (1) DNA Alkylator/Crosslinker (2) DNA Stain (4) Drug Derivative (4) Drug Intermediate (1) Drug Isomer (1) Drug Metabolite (1) Drug-Linker Conjugates for ADC (4) Endogenous Metabolite (1) Exosomes (1) Fluorescent Dye (127) Glyoxalase (GLO) (1) Isotope-Labeled Compounds (8) Microtubule/Tubulin (4) Mitochondrial Metabolism (1) Mitophagy (2) MOFs (3) Nuclear Factor of activated T Cells (NFAT) (1) PD-1/PD-L1 (1) PROTAC Linkers (14) Reactive Oxygen Species (ROS) (1) Reference Standards (1) Sodium Channel (1) Toll-like Receptor (TLR) (1) Transmembrane Glycoprotein (1)
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249

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128

Fluorescent Dyes

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-111496

Sulfo-NHS-SS-Biotin sodium 4 Publications Verification	Biochemical Assay Reagents	Others
Sulfo-NHS-SS-biotin sodium is a long-chain cleavable and cell-impermeant amine-reactive biotinylation reagent. Sulfo-NHS-SS-biotin sodium can be used for the labeling and purifying of cell-surface protein .

HY-D0975

Sulfo-SMCC sodium 5 Publications Verification	ADC Linker	Cancer
Sulfo-SMCC sodium is a commonly used hetero-bifunctional, noncleavable ADC crosslinker bearing N-hydroxysuccinimide (NHS) ester and maleimide groups to react with primary amines and sulfhydryl groups, respectively.

HY-137383

Sulfo-SANPAH	Biochemical Assay Reagents Reactive Oxygen Species (ROS)	Others
Sulfo-SANPAH is a primary amine-nitrobenzene azide cross-linker. Sulfo-SANPAH improves the functionalization process of PDMS surfaces, is covalently bound to the PAAm gel surface. Sulfo-SANPAH is widely used to crosslink ECM proteins to various substrates, including acrylic-based hydrogels, such as polyacrylamide hydrogels. Sulfo-SANPAH facilitates covalent binding through its negatively charged sulfonate group on its N-hydroxysuccinimide ester ring and a photoactivated phenyl azide group that is highly reactive with nucleophiles and free radicals .

HY-129522

Sulfo-ara-F-NMN 5+ Cited Publications CZ-48	Toll-like Receptor (TLR)	Neurological Disease
Sulfo-ara-F-NMN (CZ-48) is a mimetic of nicotinamide mononucleotide (NMN). Sulfo-ara-F-NMN acts selectively, activating SARM1 but inhibiting CD38 (IC₅₀ around 10 μM). Sulfo-ara-F-NMN induces intracellular cyclic ADP-ribose (cADPR) production .

HY-D0823

CY3-SE 1 Publications Verification Sulfo-Cy3 NHS ester; Sulfo Cyanine3 NHS ester	Fluorescent Dye	Others
Cy3-SE (Sulfo-Cy3 NHS ester; Sulfo Cyanine3 NHS ester) is a sulfonated cyanine dye-derived fluorescent labeling reagent with λ_ex of about 515 nm and λ_em of about 568 nm. Cy3-SE can interact with the π-π stacking of biomolecules (e.g., nucleoside monophosphates, proteins), inhibiting the photoisomerization process and increasing the fluorescence quantum yield and lifetime .

HY-136964

Sulfo-NHS-Biotin sodium	Biochemical Assay Reagents	Neurological Disease
Sulfo-NHS-Biotin sodium is a low-molecular-weight (MW 443.4 Da) tracer. Sulfo-NHS-Biotin sodium can used to assess blood-brain barrier permeability .

HY-101141

sulfo-SPDB-DM4	Drug-Linker Conjugates for ADC	Cancer
sulfo-SPDB-DM4 is a agent-linker conjugate for ADC by using the maytansinebased payload (DM4, an antitubulin agent) via the sulfo-SPDB linker.

HY-153631

Sulfo-TAG NHS ester disodium	Biochemical Assay Reagents	Inflammation/Immunology
Sulfo-TAG NHS ester disodium is an N-hydroxysuccinimide ester that can be coupled to proteins via primary amine groups. Sulfo-TAG NHS ester disodium can be used for antibody labeling .

HY-140341

Sulfo-NHS-Acetate	PROTAC Linkers	Cancer
Sulfo-NHS-Acetate is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-D1389

Sulfo-CY-5.5 NHS ester tripotassium 1 Publications Verification Sulfo-Cyanine5.5 NHS ester tripotassium	Fluorescent Dye	Others
Sulfo-CY-5.5 NHS ester (Sulfo-Cyanine5.5 NHS ester) tripotassium is an amine-reactive ester of sulfonated far-red Cyanine5.5 fluorophore, which can be used to label antibodies, proteins, etc., as well as for in vivo NIR imaging .

HY-145746

Sulfo-Cy5 azide	Fluorescent Dye PD-1/PD-L1	Inflammation/Immunology Cancer
Sulfo-Cy5 azide is a near-infrared fluorescent probe with favorable click chemistry reactivity. Sulfo-Cy5 azide enables fluorescence imaging, tissue and cellular visualization of PD-L1 in tumors, and site-specific modification of anti-PD-L1 antibodies. Sulfo-Cy5 azide has been employed for RNA labeling and imaging. Sulfo-Cy5 azide can be conjugated to targeting agents for fluorescence imaging in atherosclerosis and breast cancer models (Ex/Em = 645/670 nm) .

HY-101151

sulfo-SPDB	ADC Linker	Cancer
sulfo-SPDB is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-135413A

Sulfo-CY5-NHS ester potassium Sulfo-Cyanine5 NHS ester potassium	DNA Stain	Inflammation/Immunology Cancer
Sulfo-CY5-NHS ester potassium is a reactive dye and can be used for labeling protein nucleic acid .

HY-D1390A

Sulfo-Cy5-Mal	Fluorescent Dye	Others
Sulfo-Cy5-Mal is a fluorescent dye derivative composed of a CY5 dye and a maleimide functional group. Sulfo-Cy5-Mal specifically covalently binds to thiol-containing (-SH) biomolecules. Sulfo-Cy5-Mal can be used for protein labeling, antibody conjugation, molecular imaging, and drug delivery studies (Ex/Em = 633 nm/670 nm) .

HY-D1375

Sulfo-Cy5 amine	Fluorescent Dye	Others
Sulfo-Cy5 amine is a dye derivative of Cyanine 5 (Cy5) (HY-D0821) bearing an amine group. The sulfonate ion increases the water solubility of the compound, making it suitable for use in aqueous solutions. Cy5 is a near-infrared fluorescent dye commonly used in biolabeling and cell imaging. The amine functionality of Sulfo-Cy5 amine can react with carboxyl groups to form covalent bonds. Sulfo-Cy5 amine can bind to biomolecules such as proteins and antibodies to track their location and dynamic changes in biological samples.

HY-107783

Sulfo-GMBS	Biochemical Assay Reagents	Others
Sulfo-GMBS is a crosslinker widely used in chemical modification and coupling reactions of proteins and peptides. Among amine-thiol crosslinkers, Sulfo-GMBS generates the largest number of crosslinks and covers most of the crosslinks identified by AMAS and GMBS .

HY-D1365

Sulfo-Cy3(Me)COOH	Fluorescent Dye	Others
Sulfo-Cy3(Me)COOH is a sulfo-Cyanine3 derivative. Cyanine3 is an orange-fluorescent label dye for protein and nucleic acid (Ex=554 nm, Em=568 nm) .

HY-D1568

Sulfo-Cy7.5 NHS ester	Fluorescent Dye	Others
Sulfo-Cy7.5 NHS ester is a near infrared water soluble hydrophilic dye, also is an NHS ester for the modification of amine groups. Sulfo-Cy7.5 NHS ester contains a trimeth ylene bridge and has a linker arm for its attachment to proteins, peptides, and other molecules. Sulfo-Cy7.5 NHS ester can be used for the research of NIR imaging applications .

HY-127056

Sulfo DBCO-amine	PROTAC Linkers	Cancer
Sulfo DBCO-amine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs . Sulfo DBCO-amine is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-126495A

Sulfo-LC-SPDP sodium	ADC Linker	Cancer
Sulfo-LC-SPDP sodium is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-140307

Sulfo DBCO-PEG4-Maleimide	PROTAC Linkers	Cancer
Sulfo DBCO-PEG4-Maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Sulfo DBCO-PEG4-Maleimide is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-D1566

Sulfo-Cy7.5 maleimide	Fluorescent Dye	Others
Sulfo-Cy7.5 maleimide is a CY dye. CY, short for Cyanine, is a compound consisting of two nitrogen atoms connected by an odd number of methyl units. Cyanine compounds have the characteristics of long wavelength, adjustable absorption and emission, high extinction coefficient, good water solubility and relatively simple synthesis . CY dyes are of en used for the labeling of proteins, antibodies and small molecular compounds. For the labeling of protein antibodies, the combination can be completed through a simple mixing reaction. Below, we introduce the labeling method of protein antibody labeling, which has certain reference significance .

HY-140341A

Sulfo-NHS-Acetate sodium	PROTAC Linkers	Others
Sulfo-NHS-Acetate sodium is an alkyl chain-based PROTAC linker. Sulfo-NHS-Acetate sodium can be used in the synthesis of PROTACs .

HY-117080

Sulfo-EGS	Biochemical Assay Reagents	Others
Sulfo-EGS is a homobifunctional, amine-reactive chemical crosslinker. Sulfo-EGS is used to study protein-protein or protein-peptide interactions, which can determine the spatial proximity of amino acid residues in a protein complex, without relying on standards .

HY-D1541

Sulfo-Cyanine5.5 alkyne	Fluorescent Dye	Others
Sulfo-Cyanine5.5 alkyne, a near-infrared (NIR) fluorescent dye, is an alkyne modified Sulfo-Cyanine5.5 (Ex=67 8nm, Em=694 nm). Sulfo-Cyanine5.5 alkyne can react with azides for Click Chemistry labeling.

HY-D1272

Sulfo-Cy3 amine Sulfo-Cyanine3 amine	Fluorescent Dye	Others
Sulfo-Cy3 amine is a dye derivative of Cyanine 3 (Cy3) (HY-D0822) bearing an amine group. The sulfonate ion increases the water solubility of the compound, making it suitable for use in aqueous solutions. Cy3 is a fluorescent dye with a fluorescence spectrum typically in the green to orange wavelength range. The amine functionality of Sulfo-Cy3 amine can react with carboxyl groups to form covalent bonds. Sulfo-Cy3 amine can bind to biological molecules such as proteins and antibodies to track their location and dynamic changes in biological samples.

HY-137098

Sulfo-Cy3 maleimide potassium	Fluorescent Dye	Others
Sulfo-Cy3 maleimide potassium is a fluorescent dye with a maleimide functionality at the end a short alkyl linker. Sulfo-Cy3 maleimide potassium can be used for the labeling of antibodies and other labile proteins .

HY-151759

Sulfo-Cy5-TCO	Fluorescent Dye	Cancer
Sulfo-Cy5-TCO is a water-soluble sulfonated Cy5 fluorescent reagent containing trans-cyclooctene (TCO). Sulfo-Cy5-TCO undergoes an inverse electron demand Diels‑Alder reaction with tetrazine-labeled fixed breast cancer cells to achieve cell labeling. Sulfo-Cy5-TCO is used for fluorescent labeling and imaging of biological samples such as proteins and cells .

HY-125726

Sulfo galactosylceramide (3'-Sulfo)Galβ-Cer(d18:1/24:1); N-Nervonoyl Sulfatide; C24:1 Sulfatide	Nuclear Factor of activated T Cells (NFAT)	Inflammation/Immunology
Sulfo galactosylceramide (N-Nervonoyl Sulfatide; C24:1 Sulfatide) is a glycolipid and the major sulfolipid species in mature myelin. Sulfo galactosylceramide interacts with C-type lectins and immunoglobulin-like receptors, with the highest affinity for LMIR5. Sulfo galactosylceramide induces MCP-1 production by basophils but not mast cells, and increases NFAT activation via LMIR5. Sulfo galactosylceramide alleviates symptoms and improves survival in a mouse model of chronic relapsing-remitting experimental autoimmune encephalomyelitis (EAE), and reduces inflammatory lesions and the number of infiltrating mononuclear cells in the lumbar spinal cord of EAE mice.

HY-D1880

Sulfo-Cy5 hydrazide	Fluorescent Dye	Others
Sulfo-Cy5 hydrazide is a fluorescent dye containing a hydrazide functionality (Ex/Em=646/662 nm) .

HY-136158A

*6-Maleimidocaproic acid sulfo-NHS sodium* Sulfo-EMCS	PROTAC Linkers	Cancer
6-Maleimidocaproic acid sulfo-NHS (Sulfo-EMCS) sodium is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-D2241

Sulfo-Cy7-DBCO	Fluorescent Dye	Others
Sulfo-Cy7-DBCO is the water-soluble version of cyanine 7. Sulfo-Cy7-DBCO spectral properties are similar to Cy7. Sulfo-Cy7-DBCO is a near-infrared fluorescent dye .

HY-D2873

Sulfo Cy7 tyramide Sulfo Cy7(Et) tyramide	Fluorescent Dye	Others
Sulfo Cy7 tyramide, a red fluorescent dye (Ex=740 nm, Em=770 nm), is utilized as reporter fluorescent substrate of horseradish peroxidase (HRP)-catalyzed deposition for tyramide signal amplification (TSA). Sulfo Cy7 tyramide can be used for multiplex Immunohistochemistry (mIHC) .

HY-D1848A

Sulfo-Cy3-NHS ditriethylamine	Fluorescent Dye	Others
Sulfo-Cy3-NHS ditriethylamine is a derivative of Cy3 (Cyanine3) (HY-D0822) dye containing sulfonate ions. Sulfo-Cy3-NHS ditriethylamine contains sulfonate ions and has improved water solubility. Sulfo-Cy3-NHS ditriethylamine can label biomolecules containing amine groups, such as proteins, antibodies or peptides.

HY-151789

Sulfo DBCO-TFP Ester	ADC Linker	Others
Sulfo DBCO-TFP Ester is a water-soluble, sulfo-containing click chemistry reagent. Sulfo DBCO-TFP Ester enables simple and efficient incorporation of sulfo-DBCO moieties onto amine-containing molecules .

HY-W123009

Sulfo-KMUS sodium salt 11-Maleimidoundecanoic acid Sulfo-N-succinimidyl ester sodium salt	Biochemical Assay Reagents	Others
Sulfo-KMUS (sodium salt) acts as a crosslinker .

HY-404548

Sulfo-TAG TFP ester disodium	Biochemical Assay Reagents	Others
Sulfo-TAG TFP ester disodium is a tetrafluorophenyl (TFP) ester that can be coupled to proteins via primary amine groups. Sulfo-TAG TFP ester disodium is more hydrophobic than NHS esters and exhibits higher hydrolytic stability in aqueous solutions. Sulfo-TAG TFP ester disodium can be used for antibody labeling.

HY-129377

Sulfo-SPP	ADC Linker	Cancer
Sulfo-SPP is a heterobifunctional, thiol-cleavable and membrane impermeable crosslinker.

HY-151712

Sulfo-Cy5-Methyltetrazine	Fluorescent Dye	Others
Sulfo-Cy5-Methyltetrazine is a click chemistry reagent containing a methyltetrazine group. Sulfo-Cy5-Methyltetrazine acts as a fluorophore linker for trans-cyclooctene-based labeling. Sulfo-Cy5-Methyltetrazine shows good stability at physiological pH and is also highly reactive towards cyclooctene.

HY-129376

Sulfo-SNPB	ADC Linker	Cancer
Sulfo-SNPB is a cleavable linker that is used for making antibody-drug conjugate (ADC).

HY-151713

Sulfo-Cy3-Methyltetrazine	Fluorescent Dye	Others
Sulfo-Cy3-Methyltetrazine (figure 7 compound 5) is a click chemistry reagent containing methyltetrazine and a water-soluble dye. Sulfo-Cy3-Methyltetrazine shows good stability at physiological pH. Sulfo-Cy3-Methyltetrazine can be coupled to trans-cyclooctene and is also highly reactive towards cyclooctene .

HY-D1352A

Sulfo-Cyanine7 NHS ester TEA	Fluorescent Dye	Others
Sulfo-Cyanine7 NHS ester (TEA) is an amine-reactive succinimide ester. Sulfo-Cyanine7 NHS ester (TEA) reagent allows to prepare sulfo-Cyanine7-labeled biomolecules, such as proteins, with ease. Dye labeled molecules can be subsequently used for various research and agent design related experiments.

HY-126495

Sulfo-LC-SPDP	ADC Linker	Cancer
Sulfo-LC-SPDP is a heterobifunctional, thiol-cleavable and membrane impermeable crosslinker.

HY-D2487

Sulfo Cy5 bis COOH	Fluorescent Dye	Others
Sulfo Cy5 bis COOH is a derivative of Cy5 (HY-D0821) dye containing sulfonate ions. Sulfo Cy5 bis COOH contains carboxyl groups, which can condense ammonia to form covalent bonds.

HY-D1376A

Sulfo-Cyanine5.5 amine	Fluorescent Dye	Others
Sulfo-Cyanine5.5 amine consists of four sulfonate groups and has highly hydrophilic. Sulfo-Cyanine5.5 amine is an amine-containing fluorescent dye, the aliphatic primary amine group can be coupled with various electrophiles (activated esters, epoxides, etc). Sulfo-Cyanine5.5 amine can be used for the research of far red/NIR applications (such as in vivo imaging) and also can be used for enzymatic transamination labeling .

HY-151821

Sulfo DBCO-PEG3-acid	ADC Linker	Others
Sulfo DBCO-PEG3-acid is a click chemistry reagent containing an azide group. Sulfo DBCO-PEG3-acid is an analog of DBCO-Acid with PEG linker and a DBCO group. The DBCO groups is commonly used for copper-free Click Chemistry reactions due to its strain promoted high energy. The hydrophilic PEG chain and sulfo group increase water solubility. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. Reagent grade, for research use only .

HY-D2497

Sulfo Cy7 bis-SH	Fluorescent Dye	Others
Sulfo Cy7 bis-SH is a fluorescent dye that contains sulfonated Cyanine7 (Sulfo-CY7) fluorescent dye and thiol (-SH) functional group. SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds .

HY-W697935

Sulfo-TAG COOH trisodium	Drug Intermediate	Others
Sulfo-TAG COOH trisodium (Example 2) is a catalyst ligand that can be used for the synthesis of electrochemiluminescence (ECL) labels.

HY-D1351

Sulfo-Cyanine5.5 maleimide potassium Sulfo-Cy5.5 maleimide potassium	Fluorescent Dye	Others
Sulfo-Cyanine5.5 maleimide (Sulfo-Cy5.5 maleimide) potassium is a fluorescent dye. Sulfo-Cyanine5.5 is a nearinfrared (NIR) fluorophore with excitation maximum 675 nm and emission maximum 694 nm. Sulfo-Cyanine5.5 maleimide potassium can be used for the labeling of sensitive proteins, nanoparticles, and highly hydrophylic biopolymers .

HY-128954

Sulfo-PDBA-DM4	Drug-Linker Conjugates for ADC	Inflammation/Immunology Cancer
Sulfo-PDBA-DM4 is a agent-linker conjugate composed of a potent a tubulin inhibitor DM4 and a linker Sulfo-PDBA to make antibody agent conjugate (ADC). Sulfo-PDBA is a gluthatione cleavable linker.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-145535

Tetracosanoyl-sulfatide C24 3'-Sulfo Galactosylceramide (d18:1/24:0)	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Tetracosanoyl-sulfatide is an endogenous metabolite present in Urine that can be used for the research of Mild Metachromatic Leukodystrophy .

HY-D1365B

Sulfo-Cy3(Me)COOH potassium	Lipid	Fluorescent Dye
Sulfo-Cyanine 3 free acid potassium is a sulfo-Cyanine3 derivative. Cyanine3 is an orange-fluorescent label dye for protein and nucleic acid (Ex=554 nm, Em=568 nm) .

HY-N16297

*C24:0(2R-OH) Mono-sulfo* galactosyl(ß) ceramide (d18:1/24:0)**	Lipid	Biochemical Assay Reagents
C24:0(2R-OH) Mono-sulfo galactosyl(β) ceramide (d18:1/24:0) is a 2-hydroxy ceramide.

HY-N16311

*18:0 Sulfo-cyanine 5 PE ammonium*	Lipid	Fluorescent Dye
18:0 Sulfo-cyanine 5 PE ammonium is a fluorescent lipid that can be used to visualize cell membranes (Ex/Em = 650/670 nm).

HY-N16315

*Di-sulfo* squarefluor 640/660 free acid**	Lipid	Fluorescent Dye
Di-sulfo squarefluor 640/660 free acid is a fluorescent lipid that can be used to visualize cell membranes (Ex/Em = 640/660 nm).

Cat. No.	Product Name	Chemical Structure

HY-146656S

*S-Sulfo-DL-cysteine-d3*
S-Sulfo-DL-cysteine-2,3,3-d₃ is the deuterium labeled S-Sulfo-DL-cysteine-2,3,3.

HY-A0023AS2

Alogliptin-13C,d3 benzoate
Sulfo DBCO-PEG4-Maleimide TEA is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-139610S1

*3-Sulfo-glycodeoxycholic acid-d4 sodium*
3-Sulfo-glycodeoxycholic acid-d₄ (sodium) is the deuterium labeled 3-Sulfo-glycodeoxycholic acid .

HY-139610S

*3-Sulfo-glycodeoxycholic acid-d4 disodium*
3-Sulfo-glycodeoxycholic acid-d₄ (disodium) is the deuterium labeled 3-Sulfo-glycodeoxycholic acid disodium .

HY-151215S

*S-Sulfo-DL-cysteine-2,3,3-d3-1*
S-Sulfo-DL-cysteine-2,3,3-d₃-1 is the deuterium labeled S-Sulfo-DL-cysteine .

HY-146920S

*3-O-Sulfo-galactosyl(β)sphingosine (d18:1)-d7 ammonium*
3-O-Sulfo-galactosyl(β)sphingosine (d18:1)-d₇ (ammonium) is deuterium labeled 3-O-Sulfo-galactosyl(β)sphingosine (d18:1) (ammonium).

HY-146761S

*3-O-Sulfo-D-galactosyl-β1-1'-N-tridecanoyl-D-erythro-sphingosine-d7*
3-O-Sulfo-D-galactosyl-β1-1'-N-tridecanoyl-D-erythro-sphingosine-d₇ is deuterium labeled 3-O-Sulfo-D-galactosyl-β1-1'-N-tridecanoyl-D-erythro-sphingosine.

HY-146921S

*3-O-Sulfo-D-galactosyl-ß1-1’-N-nervonoyl-D-erythro-sphingosine-d7 ammonium*
3-O-Sulfo-D-galactosyl-ß1-1’-N-nervonoyl-D-erythro-sphingosine-d₇ (ammonium) is deuterium labeled 3-O-Sulfo-D-galactosyl-ß1-1’-N-nervonoyl-D-erythro-sphingosine (ammonium).

Cat. No.	Product Name		Classification

HY-D1068

Cy5-DBCO 1 Publications Verification DBCO-Sulfo-Cy5		Labeling and Fluorescence Imaging DBCO
Cy5-DBCO (DBCO-Sulfo-Cy5) is a near-infrared (NIR)red fluorescent dye with λ_absand λ_em of 646nm and 670 nm, respectively. Cy5-DBCO (DBCO-Sulfo-Cy5) is not suitable for staining intracellular components of permeabilezed cell, it may exhibits a high background. Cy5-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-D1069

DBCO-Cy3 1 Publications Verification DBCO-Sulfo-Cy3		Labeling and Fluorescence Imaging DBCO
DBCO-Cy3 (DBCO-Sulfo-Cy3) is the derivative of Cyanine3 fluorophore, a pH insensitive from pH (4-10) orange fluorescent dyewith excitation maximum 555 nm and emission maximum of 580nm. DBCO-Cy3 has fast reaction kinetics and good stability, and is productive to use in many standard fluorescent instrumentations. DBCO-Cy3 is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-145746

Sulfo-Cy5 azide		Labeling and Fluorescence Imaging Azide
Sulfo-Cy5 azide is a near-infrared fluorescent probe with favorable click chemistry reactivity. Sulfo-Cy5 azide enables fluorescence imaging, tissue and cellular visualization of PD-L1 in tumors, and site-specific modification of anti-PD-L1 antibodies. Sulfo-Cy5 azide has been employed for RNA labeling and imaging. Sulfo-Cy5 azide can be conjugated to targeting agents for fluorescence imaging in atherosclerosis and breast cancer models (Ex/Em = 645/670 nm) .

HY-123687

*DBCO-Sulfo-NHS ester sodium*		DBCO ADC Synthesis
DBCO-Sulfo-NHS ester sodium is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . DBCO-Sulfo-NHS ester (sodium) is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-D0832

CY5-N3 1 Publications Verification Sulfo-Cyanine5-azide		Labeling and Fluorescence Imaging Azide
CY5-N3 (Sulfo-Cyanine5-azide) is a Cy5-azide, which is a fluorescent dye (ex/em: 646/662 nm). CY5-N3 is cell membrane permeable and can be used for live cell imaging. CY5-N3 can be used in cell imagine by Click reaction .

HY-130810

*DBCO-Sulfo-Link-biotin*		DBCO ADC Synthesis
DBCO-Sulfo-Link-biotin is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . DBCO-Sulfo-Link-biotin is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-140286

Sulfo DBCO-PEG4-amine		DBCO
Sulfo DBCO-PEG4-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-151710

Sulfo-Cy3 Azide		Labeling and Fluorescence Imaging Azide
Sulfo-Cy3 Azide is a water-soluble fluorogenic dye containing an azide group, which enables Click Chemistry. Sulfo-Cy3 Azide can be used for the labeling of sensitive molecules such as proteins . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-W400925

Sulfo-Cy5-N3		Azide
Sulfo-Cy5-N3 is a click chemistry reagent containing an azide group. Cy5 is a red fluorescent label dye for imaging (Ex/Em=642/670 nm) . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-127056

Sulfo DBCO-amine		PROTAC Synthesis DBCO
Sulfo DBCO-amine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs . Sulfo DBCO-amine is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-140307

Sulfo DBCO-PEG4-Maleimide		PROTAC Synthesis DBCO
Sulfo DBCO-PEG4-Maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Sulfo DBCO-PEG4-Maleimide is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-151711

Sulfo-Cy5.5 Azide		Azide Labeling and Fluorescence Imaging
Sulfo-Cy5.5 Azide is a click chemistry reagent containing an azide group. Sulfo-Cy5.5 Azide is also a water-soluble dye (Ex=673 nm, Em=707 nm), which designed to label sensitive molecules such as peptides, proteins and oligonucleotides. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-D0820

CY5-YNE Sulfo-Cyanine5-alkyne		Alkynes Labeling and Fluorescence Imaging
CY5-YNE (Sulfo-Cyanine5-alkyne) is a reactive dye for the labeling of amino-groups in peptides, proteins, and oligonucleotides (Ex: 650 nM; Em: 680 nm). CY5-YNE is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-151759

Sulfo-Cy5-TCO		TCO Labeling and Fluorescence Imaging
Sulfo-Cy5-TCO is a water-soluble sulfonated Cy5 fluorescent reagent containing trans-cyclooctene (TCO). Sulfo-Cy5-TCO undergoes an inverse electron demand Diels‑Alder reaction with tetrazine-labeled fixed breast cancer cells to achieve cell labeling. Sulfo-Cy5-TCO is used for fluorescent labeling and imaging of biological samples such as proteins and cells .

HY-D1482

Sulfo-Cy5-tetrazine		Tetrazine Labeling and Fluorescence Imaging
Sulfo Cy5-tetrazine is a tetrazine-coupled Cy5 (HY-D0821) derivative dye with fluorescence properties similar to CY5 (Ex/Em=633/647 nm). Sulfo-Cy5-tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups .

HY-140307A

Sulfo DBCO-PEG4-Maleimide TEA		DBCO
Sulfo DBCO-PEG4-Maleimide TEA is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Sulfo DBCO-PEG4-Maleimide (TEA) is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-D1274C

Sulfo-cyanine3 azide potassium		Azide
Sulfo-cyanine3 azide potassium is an azide cyanine dye and fluorescent probe (Ex/Em=548/563 nm). Sulfo-cyanine3 azide potassium can be used for synthesis of fused tricyclic heterocycles, producing immunostimulatory agents . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-D0818

CY3-YNE Sulfo-Cyanine3-alkyne		Alkynes
CY3-YNE (Sulfo-Cyanine3-alkyne) is a dye for the labeling of soluble proteins, peptides, and oligonucleotides/DNA. CY3-YNE is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-D1053

CY7-N3 Sulfo-Cyanine7-N3		Azide Labeling and Fluorescence Imaging
CY7-N3 (Sulfo-Cyanine7-N3) is a water-soluble NIR dye azide for Click Chemistry. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-D2241

Sulfo-Cy7-DBCO		DBCO
Sulfo-Cy7-DBCO is the water-soluble version of cyanine 7. Sulfo-Cy7-DBCO spectral properties are similar to Cy7. Sulfo-Cy7-DBCO is a near-infrared fluorescent dye .

HY-151789

Sulfo DBCO-TFP Ester		DBCO
Sulfo DBCO-TFP Ester is a water-soluble, sulfo-containing click chemistry reagent. Sulfo DBCO-TFP Ester enables simple and efficient incorporation of sulfo-DBCO moieties onto amine-containing molecules .

HY-151712

Sulfo-Cy5-Methyltetrazine		Tetrazine Labeling and Fluorescence Imaging
Sulfo-Cy5-Methyltetrazine is a click chemistry reagent containing a methyltetrazine group. Sulfo-Cy5-Methyltetrazine acts as a fluorophore linker for trans-cyclooctene-based labeling. Sulfo-Cy5-Methyltetrazine shows good stability at physiological pH and is also highly reactive towards cyclooctene.

HY-151713

Sulfo-Cy3-Methyltetrazine		Tetrazine Labeling and Fluorescence Imaging
Sulfo-Cy3-Methyltetrazine (figure 7 compound 5) is a click chemistry reagent containing methyltetrazine and a water-soluble dye. Sulfo-Cy3-Methyltetrazine shows good stability at physiological pH. Sulfo-Cy3-Methyltetrazine can be coupled to trans-cyclooctene and is also highly reactive towards cyclooctene .

HY-141268

*Methyltetrazine-Sulfo-NHS ester sodium*		Tetrazine
Methyltetrazine-Sulfo-NHS ester (sodium) is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-151821

Sulfo DBCO-PEG3-acid		DBCO
Sulfo DBCO-PEG3-acid is a click chemistry reagent containing an azide group. Sulfo DBCO-PEG3-acid is an analog of DBCO-Acid with PEG linker and a DBCO group. The DBCO groups is commonly used for copper-free Click Chemistry reactions due to its strain promoted high energy. The hydrophilic PEG chain and sulfo group increase water solubility. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. Reagent grade, for research use only .

HY-151769

*TCO-PEG2-Sulfo-NHS ester-EDC Urea*		Labeling and Fluorescence Imaging TCO
TCO-PEG2-Sulfo-NHS ester-EDC Urea is a click chemistry reagent containing an azide group. TCO-PEG2-Sulfo-NHS ester is a PEG linker containing a TCO moiety and a sulfo-NHS ester moiety. The sulfo group makes this molecule soluble in waqueous buffer. This reagent can be used to label antibodies, proteins and other primary amine-containing macromolecules with TCO moiety. Reagent grade, for research use only . TCO-PEG2-Sulfo-NHS ester-EDC Urea is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

HY-141172

*TCO-PEG2-Sulfo-NHS ester*		TCO
TCO-PEG2-Sulfo-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-W879040

Sulfo-DBCO-NHS ester		DBCO
Sulfo-DBCO-NHS ester is a click chemistry reagent containing an azide group. The DBCO group is commonly used for copper-free Click Chemistry reactions due to its strain promoted high energy. NHS ester can bind to amino acids or other molecules containing amino groups .

HY-D2750

Sulfo-Cy5 picolyl azide		Azide
Sulfo-Cy5 Picolyl Azide is a fluorophore featuring a sulfonate group and an azide. Azide groups are click chemistry handles which are reactive towards terminal alkynes and strained cyclooctynes such as BCN or DBCO. Cy5 is a cyanine dye with excitation and emission maxima at 651 nm and 670 nm respectively. The sulfonate group on the Cy5 dye increases this compound’s water solubility.

HY-140306

*Mal-Sulfo-DBCO*		ADC Synthesis DBCO
Mal-Sulfo-DBCO is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Mal-Sulfo-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-D2880

Sulfo-Cyanine5 DBCO		DBCO
Sulfo-Cyanine5 DBCO is a near-infrared red (NIR) fluorescent dye. Sulfo-Cyanine5 DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups (Ex/Em =646/670 nm) .

HY-148840

Sulfo DBCO-PEG3-NHS ester		DBCO
Sulfo DBCO-PEG3-NHS ester is a click chemistry reagent containing an azide group. Sulfo DBCO-PEG3-NHS ester is an analog of DBCO-Acid with PEG linker and a DBCO group. The DBCO group is commonly used for copper-free Click Chemistry reactions due to its strain promoted high energy. The hydrophilic PEG chain and sulfo group increase water solubility. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. Reagent grade, for research use only .

HY-D2242

Sulfo-Cy7.5 DBCO		DBCO
Sulfo-Cy7.5 DBCO is a dye derivative of Cyanine 7.5 (Cy7.5) (HY-D0926) bearing a DBCO group. The sulfonate ion increases the water solubility of the compound, making it suitable for use in aqueous solutions. Sulfo-Cy7.5 DBCO can bind to biomolecules such as proteins and antibodies to track their location and dynamic changes in biological samples .

HY-D1274

Sulfo-cyanine3 azide		Azide
Sulfo-cyanine3 azide is an azide cyanine dye and fluorescent probe (Ex/Em=548/563 nm). Sulfo-cyanine3 azide can be involved in synthesis of fused tricyclic heterocycles, produces immunostimulatory agents . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-D1274A

Sulfo-cyanine3 azide sodium		Labeling and Fluorescence Imaging Azide
Sulfo-cyanine3 azide sodium a water-soluble azide cyanine dye and fluorescent probe (Ex/Em=548/563 nm). Sulfo-cyanine3 azide sodium can be involved in synthesis of fused tricyclic heterocycles, produces immunostimulatory agents . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-W123028

Sulfo-SANPAH sodium		Azide
Sulfo-SANPAH (sodium) is a biochemical reagent .

HY-D1598

Sulfo-CY3 tetrazine potassium		Tetrazine Labeling and Fluorescence Imaging
Sulfo-CY3 tetrazine potassium is a sulfo-Cyanine3 derivative that contains methyltetrazine moiety (Ex=548 nm, Em=563 nm). Sulfo-CY3 tetrazine potassium can be used for the labeling of metabolically engineered cell-surface glycoconjugates . Sulfo-CY3 tetrazine (potassium) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

HY-D2499

Sulfo Cy7 DBCO potassium		DBCO
Sulfo Cy7 DBCO potassium is a dye derivative of CY7 (HY-D0825) bearing a DBCO group. Sulfo Cy7 DBCO potassium is a click chemistry reagent. Sulfo Cy7 DBCO potassium contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups .

HY-D2219

Sulfo-Cy7 tetrazine		Tetrazine
Sulfo-Cy7 tetrazine is a near-infrared water-soluble fluorophore. Sulfo-Cy7 tetrazine contains the methyltetrazine group for rapid, efficient, and metal-free conjugation to cycloolefin in a reaction called TCO linkage .

HY-D2240

Sulfo-Cy3.5-DBCO		DBCO
Sulfo-Cy3.5-DBCO is a fluorescent dye. Sulfo-Cy3.5-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-D1308

Sulfo-Cyanine5.5 azide tripotassium		Azide
Sulfo-Cyanine5.5 azide tripotassium, a near-infrared (NIR) fluorescent dye, is an azide-functionalized Sulfo-Cyanine5.5 (Ex=678 nm, Em=694 nm). Sulfo-Cyanine5.5 azide tripotassium can react with alkynes for Click Chemistry labeling . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-141172A

*TCO-PEG2-Sulfo-NHS ester sodium*		PROTAC Synthesis TCO
TCO-PEG2-Sulfo-NHS ester sodium is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-D1859

Sulfo-Cy7.5 alkyne		Alkynes
Sulfo-Cy7.5 alkyne is a dye derivative of Cyanine 7.5 (Cy7.5) (HY-D0926) containing a sulfonate ion and an alkyne functional group. The sulfonate ion increases the water solubility of the compound, making it suitable for use in aqueous solutions. Cy7.5 is a near-infrared fluorescent dye commonly used for biolabeling and cell imaging. The alkyne functionality of Sulfo-Cy7.5 alkyne can react with molecules containing the azide functionality to form covalent bonds. Sulfo-Cy7.5 alkyne can bind to biomolecules such as proteins and antibodies to track their location and dynamic changes in biological samples.

HY-148840A

Sulfo DBCO-PEG3-NHS ester TEA		DBCO
Sulfo DBCO-PEG3-NHS ester TEA is a click chemistry reagent containing an azide group. Sulfo DBCO-PEG3-NHS ester (TEA) is an analog of DBCO-Acid with PEG linker and a DBCO group. The DBCO group is commonly used for copper-free Click Chemistry reactions due to its strain promoted high energy. The hydrophilic PEG chain and sulfo group increase water solubility. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. Reagent grade, for research use only .

HY-D1307A

Sulfo-cyanine7 alkyne potassium		Alkynes
Sulfo-cyanine7 alkyne potassium is a water-soluble near-infrared dye with a sulfonated terminal alkyne that can be used in copper-catalyzed click chemistry reactions to conjugate with azides in an aqueous environment.

HY-D1307

Sulfo-cyanine7 alkyne		Alkynes
Sulfo-cyanine7 alkyne is a water-soluble near-infrared dye with a sulfonated terminal alkyne that can be used in copper-catalyzed click chemistry reactions to conjugate with azides in an aqueous environment.

HY-163789

*Desthiobiotin-PEG3-triazole-DBCO-sulfo-Maleimide*		DBCO
Desthiobiotin-PEG3-triazole-DBCO-sulfo-Maleimide is an ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Desthiobiotin-PEG3-triazole-DBCO-sulfo-Maleimide is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups .

HY-D1274B

Sulfo-cyanine3 azide TEA		Azide
Sulfo-cyanine3 azide TEA is an azide cyanine dye and fluorescent probe (Ex/Em=548/563 nm). Sulfo-cyanine3 azide TEA can be involved in synthesis of fused tricyclic heterocycles, produces immunostimulatory agents . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-W123019

*DBCO-Sulfo-Link-biotin TEA*		DBCO
DBCO-Sulfo-Link-biotin TEA is a click chemistry intermediate containing a DBCO group, which can undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing an azide group.

HY-D1850

Sulfo-Cy7.5 azide		Azide
Sulfo-Cy7.5 azide is a Cyanine 7.5 (Cy7.5) (HY-D0926) dye derivative with azide and sulfonate functional groups. The sulfonate ion increases the water solubility of the compound, making it suitable for use in aqueous solutions. Cy7.5 is a near-infrared fluorescent dye commonly used for biolabeling and cell imaging. The azide group of Sulfo-Cy7.5 azide can react chemically with molecules containing alkyne functionality, such as alkyne or cyclooctyne, to form covalent bonds. Therefore, Sulfo-Cy7.5 azide can bind to biomolecules such as proteins and antibodies to track their location and dynamic changes in biological samples. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

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