Sulfo-Cyanine7 carboxylic acid

Sprague Dawley (male, 280 g)^[2]

2 mg/mL (saline solution); 2 mg/mL (MEO-NE); 2 mg/mL (plain gel base); 2 mg/mL (MEO-NE-loaded gel)

i.n.; single 100 µL dose

Showed strongest fluorescence intensity in brain and trigeminal nerve at 30 min post-administration for saline solution formulation.
Demonstrated significantly higher average radiant efficiency (ARE) values in brain than saline solution group at 10 min, 2 h, and 3 h for MEO-NE solution formulation.
Exhibited significantly higher ARE values in trigeminal nerve than saline solution group at 10 min and 2 h for MEO-NE solution formulation.
Displayed weaker fluorescence intensity than MEO-NE-loaded gel group at all time points for plain gel formulation.
Showed significantly higher ARE values in brain than plain gel group at 10 min, 30 min, and 2 h for MEO-NE-loaded gel formulation.
Exhibited significantly higher ARE values in trigeminal nerve than plain gel group at 10 min, 30 min, and 2 h for MEO-NE-loaded gel formulation.
Demonstrated significantly higher ARE values in both brain and trigeminal nerve than MEO-NE solution group at all time points except 30 min for MEO-NE-loaded gel formulation.