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Cat. No.: HY-W550859

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H-Phe(4-SO3H)-OH

(Synonyms: 4-Sulfo-L-phenylalanine)

H-Phe(4-SO₃H)-OH (4-Sulfo-L-phenylalanine) is a L-phenylalanine (HY-N0215) derivative. H-Phe(4-SO₃H)-OH induces apoptosis, chromatin margination, and inhibits cell growth in human colon cancer cells. H-Phe(4-SO₃H)-OH can be used for the research of colon cancer.

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CAS No.: 34023-49-9
Formule: C₉H₁₁NO₅S
Masse moléculaire:245.25

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

H-Phe(4-SO3H)-OH Chemical Structure

CAS No.: 34023-49-9

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Activité biologique
- Description
- In Vitro
Chemical Information
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Activité biologique

Description

In Vitro

H-Phe(4-SO₃H)-OH (24-120 h) exhibits cytotoxicity against human colon cancer cell line HT-29 with an LD₅₀ of 8.2 mmol at 120 h^[2].
H-Phe(4-SO₃H)-OH (24-120 h) induces apoptosis in human colon cancer cell line HT-29, evidenced by chromatin marginalization, apoptotic body formation, and reduced cell numbers over 24 h to 120 h of treatment^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 34023-49-9
Masse moléculaire 245.25
Formule C₉H₁₁NO₅S
SMILES

S(=O)(=O)(O)C1=CC=C(C[C@@H](C(O)=O)N)C=C1
Synonyms

4-Sulfo-L-phenylalanine
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Etoga JL, et al. Conformationally-restricted amino acid analogues bearing a distal sulfonic acid show selective inhibition of system x(c)(-) over the vesicular glutamate transporter. Bioorg Med Chem Lett. 2010;20(8):2680-2683. [Content Brief]

[2]. Qianyi Zhao, et al. Synthesis of Six Phenylalanine Derivatives and their Cell Toxicity Effect on Human Colon Cancer Cell Line HT-29. Letters in Drug Design & Discovery, Volume 12, Issue 6, Jul 2015, p. 466-470.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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