Sulfo-Cy5 azide
Based on 1 Customer Validation
Sulfo-Cy5 azide is a near-infrared fluorescent probe with favorable click chemistry reactivity. Sulfo-Cy5 azide enables fluorescence imaging, tissue and cellular visualization of PD-L1 in tumors, and site-specific modification of anti-PD-L1 antibodies. Sulfo-Cy5 azide has been employed for RNA labeling and imaging. Sulfo-Cy5 azide can be conjugated to targeting agents for fluorescence imaging in atherosclerosis and breast cancer models (Ex/Em = 645/670 nm).
For research use only. We do not sell to patients.
- Purity: 98.97%
- CAS No.: 1782950-80-4
- Formula: C37H48N6O10S3
- Molecular Weight:833.01
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Sulfo-Cy5 azide covalently conjugates to alkyne-modified ADP-ribose units on ARTD1 and histone H1.2 via click chemistry, enabling fluorescent detection of ADP-ribosylation events catalyzed by ARTD1 with alkyne-containing NAD+ analogues[1].
Sulfo-Cy5 azide covalently conjugates to alkyne-functionalized TMV coat proteins via CuAAC[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
670
645
Chemical Information
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CAS No. 1782950-80-4
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Appearance Solid
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Molecular Weight 833.01
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Formula C37H48N6O10S3
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Color Brown to dark brown
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SMILES
[N-]=[N+]=NCCCNC(CCCCCN1C2=CC=C(S(=O)(O)=O)C=C2C(C)(C)/C1=C\C=C\C=C\C3=[N+](CCCS(=O)([O-])=O)C4=C(C3(C)C)C=C(S(=O)(O)=O)C=C4)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 5 mg/mL (6.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Wang Y, et al. Chain-terminating and clickable NAD⁺ analogues for labeling the target proteins of ADP-ribosyltransferases. Angew Chem Int Ed Engl. 2014;53(31):8159-8162. [Content Brief]
[2]. Bruckman MA, et al. Dual-modal magnetic resonance and fluorescence imaging of atherosclerotic plaques in vivo using VCAM-1 targeted tobacco mosaic virus. Nano Lett. 2014;14(3):1551-1558. [Content Brief]
[3]. Hagemans IM, et al. Multiscale imaging of therapeutic anti-PD-L1 antibody localization using molecularly defined imaging agents. J Nanobiotechnology. 2022;20(1):64. Published 2022 Feb 2. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.2005 mL | 6.0023 mL | 12.0047 mL | 30.0116 mL |
| 5 mM | 0.2401 mL | 1.2005 mL | 2.4009 mL | 6.0023 mL |
Sulfo-Cy5 azide Related Classifications
HY-145746 Related Classifications
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