1782950-80-4
Chemical Structure
Sulfo-Cy5 azide
- CAS No.: 1782950-80-4
- Formula:C37H48N6O10S3
- Molecular Weight:833.01
IUPAC Name: N-(4-(1,1,1,3,3,3-hexafluoro-2-methoxypropan-2-yl)-3-isobutylphenyl)-N-isobutyryl-1,3,5-trimethyl-1H-pyrazole-4-carboxamide
InChIKey: DUWZWZJMKCNGSI-UHFFFAOYSA-N
SMILES: [N-]=[N+]=NCCCNC(CCCCCN1C2=CC=C(S(=O)(O)=O)C=C2C(C)(C)/C1=C\C=C\C=C\C3=[N+](CCCS(=O)([O-])=O)C4=C(C3(C)C)C=C(S(=O)(O)=O)C=C4)=O
Biological Activity: Sulfo-Cy5 azide is a near-infrared fluorescent probe with favorable click chemistry reactivity. Sulfo-Cy5 azide enables fluorescence imaging, tissue and cellular visualization of PD-L1 in tumors, and site-specific modification of anti-PD-L1 antibodies. Sulfo-Cy5 azide has been employed for RNA labeling and imaging. Sulfo-Cy5 azide can be conjugated to targeting agents for fluorescence imaging in atherosclerosis and breast cancer models (Ex/Em = 645/670 nm)[1][2][3].
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Sulfo-Cy5 azide | 98.97% | Sulfo-Cy5 azide is a near-infrared fluorescent probe with favorable click chemistry reactivity. Sulfo-Cy5 azide enables fluorescence imaging, tissue and cellular visualization of PD-L1 in tumors, and site-specific modification of anti-PD-L1 antibodies. Sulfo-Cy5 azide has been employed for RNA labeling and imaging. Sulfo-Cy5 azide can be conjugated to targeting agents for fluorescence imaging in atherosclerosis and breast cancer models (Ex/Em = 645/670 nm). | ||||||||||||||||||||
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References
- [1]. Wang Y, et al. Chain-terminating and clickable NAD⁺ analogues for labeling the target proteins of ADP-ribosyltransferases. Angew Chem Int Ed Engl. 2014;53(31):8159-8162. [Content Brief]
- [2]. Bruckman MA, et al. Dual-modal magnetic resonance and fluorescence imaging of atherosclerotic plaques in vivo using VCAM-1 targeted tobacco mosaic virus. Nano Lett. 2014;14(3):1551-1558. [Content Brief]
- [3]. Hagemans IM, et al. Multiscale imaging of therapeutic anti-PD-L1 antibody localization using molecularly defined imaging agents. J Nanobiotechnology. 2022;20(1):64. Published 2022 Feb 2. [Content Brief]
