sulfo-DGN462 sodium

Cat. No.: HY-101150A: FAQs
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sulfo-DGN462 sodium is degraded to DGN462 in culture medium and plasma. DGN462, a potent DNA-alkylating agent, shows anti-tumor activity, such as acute myeloid leukemia (AML).

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sulfo-DGN462 sodium Chemical Structure

CAS No. : 1401203-09-5

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Other Forms of sulfo-DGN462 sodium:

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Description	sulfo-DGN462 sodium is degraded to DGN462 in culture medium and plasma. DGN462, a potent DNA-alkylating agent, shows anti-tumor activity, such as acute myeloid leukemia (AML)^[1].
In Vitro	DGN462 can be used as a cytotoxic component of antibody-drug conjugates (ADCs). DGN462 is a member of the DNA-alkylating indolinobenzodiazepine pseudodimers (IGNs) class^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. sulfo-DGN462 sodium Related Antibodies
Molecular Weight	1046.19
Formula	C₅₃H₆₀N₅NaO₁₂S₂
CAS No.	1401203-09-5
SMILES	O=C(C1=CC(OC)=C2OCC3=CC(N(CC(C)(S)C)CCOCCOCCOC)=CC(COC(C=C(NC[C@@]4([H])N(C5=CC=CC=C5C4)C6=O)C6=C7)=C7OC)=C3)N(C8=CC=CC=C8C9)[C@]9([H])C(NC1=C2)[S](=O)(O[Na])=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (275 KB) Handling Instructions (2659 KB)
References	[1]. Hicks SW, et al. The novel CD19-targeting antibody-drug conjugate huB4-DGN462 shows improved anti-tumor activity compared to SAR3419 in CD19-positive lymphoma and leukemia models. Haematologica. 2019 Aug;104(8):1633-1639. [Content Brief]

sulfo-DGN462 sodium Related Classifications

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

sulfo-DGN4621401203-09-5DNA Alkylator/CrosslinkerADC CytotoxinADC PayloaddegradedculturemediumplasmacytotoxicAMLmyeloidleukemiaInhibitorinhibitorinhibit

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sulfo-DGN462 sodium

Other Forms of sulfo-DGN462 sodium:

sulfo-DGN462 sodium Related Antibodies

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