1. Cell Cycle/DNA Damage
  2. DNA Alkylator/Crosslinker
  3. DGN462

DGN462 

Cat. No.: HY-101150
Handling Instructions

DGN462, a potent DNA-alkylating agent, shows anti-tumor activity, such as in acute myeloid leukemia (AML). DGN462 can be used as a cytotoxic component of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

DGN462 Chemical Structure

DGN462 Chemical Structure

CAS No. : 1394079-41-4

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Description

DGN462, a potent DNA-alkylating agent, shows anti-tumor activity, such as in acute myeloid leukemia (AML). DGN462 can be used as a cytotoxic component of antibody-drug conjugates (ADCs)[1].

In Vitro

DGN462 is a member of the DNA-alkylating indolinobenzodiazepine pseudodimers (IGNs) class[1].

Molecular Weight

942.13

Formula

C₅₃H₅₉N₅O₉S

CAS No.

1394079-41-4

SMILES

O=C1N2[[email protected]](CC3=C2C=CC=C3)([H])CNC4=CC(OCC5=CC(N(CC(C)(S)C)CCOCCOCCOC)=CC(COC6=C(OC)C=C7C(N8[[email protected]](CC9=C8C=CC=C9)([H])C=NC7=C6)=O)=C5)=C(OC)C=C14

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

DGN462DGN 462DGN-462DNA Alkylator/Crosslinkeranti-tumoractivityacutemyeloidleukemiaAMLcytotoxiclymphomaInhibitorinhibitorinhibit

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