1. Antibody-drug Conjugate/ADC Related
  2. Drug-Linker Conjugates for ADC
  3. Sulfo-SPDB-DGN462

Sulfo-SPDB-DGN462 

Cat. No.: HY-136291
Handling Instructions

Sulfo-SPDB-DGN462 is a drug-linker conjugate for ADC. Sulfo-SPDB-DGN462 consists a toxin DGN462 (HY-101150) conjugated to the cleavable Sulfo-SPDB linker. DGN462, a potent DNA-alkylating agent, shows anti-tumor activity, such as acute myeloid leukemia (AML).

For research use only. We do not sell to patients.

Sulfo-SPDB-DGN462 Chemical Structure

Sulfo-SPDB-DGN462 Chemical Structure

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Description

Sulfo-SPDB-DGN462 is a drug-linker conjugate for ADC. Sulfo-SPDB-DGN462 consists a toxin DGN462 (HY-101150) conjugated to the cleavable Sulfo-SPDB linker. DGN462, a potent DNA-alkylating agent, shows anti-tumor activity, such as acute myeloid leukemia (AML)[1].

IC50 & Target

Maytansinoids

 

Molecular Weight

1251.40

Formula

C₆₁H₆₆N₆O₁₇S₃

SMILES

O=C1N2[[email protected]](CC3=C2C=CC=C3)([H])CNC4=CC(OCC5=CC(N(C(C(C)(C)SSCCC(S(=O)(O)=O)C(ON6C(CCC6=O)=O)=O)=O)CCOCCOCCOC)=CC(COC7=C(OC)C=C8C(N9[[email protected]](CC%10=C9C=CC=C%10)([H])C=NC8=C7)=O)=C5)=C(OC)C=C14

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Sulfo-SPDB-DGN462Drug-Linker Conjugates for ADCdrug-linkerconjugateADCcancerDNAacutemyeloidleukemiaAMLInhibitorinhibitorinhibit

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Sulfo-SPDB-DGN462
Cat. No.:
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