2. Search Result
Search Result
Pathways Recommended: Anti-infection
Results for "

anti biofilm

" in MedChemExpress (MCE) Product Catalog:

86

Inhibitors & Agonists

3

Biochemical Assay Reagents

9

Peptides

27

Natural
Products

5

Isotope-Labeled Compounds

1

Click Chemistry

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W010155
    Tryptophol
    2 Publications Verification

    Indole-3-ethanol

    		 Endogenous Metabolite Apoptosis Caspase Bacterial Infection Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology
    Tryptophol is an aromatic alcohol and secondary metabolite produced by microorganisms. Tryptophol induces apoptosis and cleavage of caspase-8. Tryptophol inhibits Cunninghamella blakesleeana biofilm. Tryptophol has anti-phage infection, biofilm formation regulation, anti-inflammatory, hemolytic, sleep induction, temperature change, seizure susceptibility and immune regulation activities. Tryptophol is used in the research of African trypanosomiasis, sleep disorders, epilepsy .
    Tryptophol
  • HY-110382
    Cyclic-di-GMP disodium
    Maximum Cited Publications
    9 Publications Verification

    c-di-GMP disodium; cyclic diguanylate disodium; 5GP-5GP disodium

    		 STING Endogenous Metabolite Cancer
    Cyclic-di-GMP disodium is a STING agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic-di-GMP disodium has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP disodium can be used in cancer research .
    Cyclic-di-GMP disodium
  • HY-17594
    Oxyclozanide
    4 Publications Verification

    		 Oxidative Phosphorylation Parasite Bacterial Fungal Infection
    Oxyclozanide is an orally active salicylanilide anthelmintic agent that mainly acts by uncoupling oxidative phosphorylation in flukes. Oxyclozanide shows good anti-adenovirus, anti-biofilm, antifungal, and antibacterial activity .
    Oxyclozanide
  • HY-W015551
    trans-2-Decenal

    (E)-Dec-2-enal

    		 Bacterial Reactive Oxygen Species (ROS) Infection
    trans-2-Decenal ((E)-Dec-2-enal) acts as a urease inhibitor and antibacterial agent against Helicobacter pylori, with an IC50 of 9.484 μg/mL against Helicobacter pylori urease. trans-2-Decenal reduces the urease activity of Helicobacter pylori, and possesses antibacterial, bactericidal, anti-biofilm and anti-migratory activities. It alters the morphology of Helicobacter pylori, induces bacterial rupture, inhibits biofilm formation, reduces the number of mature biofilms and impairs the migratory capacity of Helicobacter pylori. trans-2-Decenal disrupts the cell wall integrity of Phytophthora capsici, damages membrane integrity and permeability, triggers intracellular reactive oxygen species (ROS) accumulation, decreases glutathione levels and disrupts the mitochondrial membrane potential of Phytophthora capsici. trans-2-Decenal is applicable to studies related to Helicobacter pylori and plant diseases induced by and Phytophthora capsici .
    trans-2-Decenal
  • HY-N2116
    Ginkgolic acid C17:1
    1 Publications Verification

    		 PTEN Fatty Acid Synthase (FASN) STAT Apoptosis SARS-CoV Infection Cancer
    Ginkgolic acid C17:1 is a fatty acid synthase (FAS) inhibitor with an IC50 of 10.5 µM. Ginkgolic acid C17:1 shows anti-tumor activity by inhibiting the phosphorylation of STAT3 and inducing apoptosis. Ginkgolic acid C17:1 can block the interaction between S-RBD and ACE2, and has anti-SARS-CoV-2-S pseudovirus activity. Ginkgolic acid C17:1 inhibits the biofilm formation of enterohemorrhagic Escherichia coli and Staphylococcus aureus .
    Ginkgolic acid C17:1
  • HY-W015490
    1,4-Naphthoquinone
    3 Publications Verification

    		 Environmental Pollutants DNA/RNA Synthesis NF-κB Monoamine Oxidase TNF Receptor Bacterial Infection Inflammation/Immunology Cancer
    1,4-Naphthoquinone is an inhibitor with broad-spectrum inhibitory activity targeting DNA polymerase, NF-κB and monoamine oxidase (MAO-A/B), with antibacterial and anti-biofilm efficacy. 1,4-Naphthoquinone is a competitive inhibitor of MAO-B (Ki=1.4 μM) and a non-competitive inhibitor of MAO-A (Ki=7.7 μM). 1,4-Naphthoquinone inhibits DNA polymerase pol α, β, γ, δ, ε, λ with IC50 ranging from 5.57-128 μM. 1,4-Naphthoquinone inhibits tumor cell proliferation, induces apoptosis and necrosis, and has anti-angiogenic and anti-inflammatory activities by inducing oxidative stress, depleting glutathione (GSH), inhibiting DNA polymerase-mediated DNA synthesis and blocking NF-κB nuclear translocation. 1,4-Naphthoquinone can be used in anti-bacterial , anti-tumor and anti-inflammatory studies, including inhibition of melanoma and colon cancer cell growth and endothelial cell function, as well as LPS-induced inflammation models .
    1,4-Naphthoquinone
  • HY-121362
    Evernic Acid

    		Bacterial Endogenous Metabolite TrxR Infection Neurological Disease Inflammation/Immunology Cancer
    Evernic Acid is an orally active thioredoxin reductase 1 (TrxR1) inhibitor and antiproliferative agent. Evernic Acid inhibits the proliferation and migration of human breast cancer cells. Evernic Acid blocks the NF-κB pathway by inhibiting p65 nuclear translocation and IκBα phosphorylation, thereby suppressing downstream inflammatory mediators. Evernic Acid acts as an antioxidant, anti-inflammatory agent and neuroprotective agent, protects neurons from cell death, mitochondrial dysfunction and oxidative stress damage, reduces astrocyte activation, and ameliorates dopaminergic neuron loss and neuroinflammation. Evernic Acid inhibits enoyl reductases FabI and FabZ of Plasmodium falciparum. Evernic Acid downregulates the expression of lasB and rhlA genes in Pseudomonas aeruginosa, inhibits quorum sensing and biofilm formation, and exerts antibacterial activity against Gram-positive bacteria, Gram-negative bacteria and fungi. Evernic Acid is applicable to research related to breast cancer, Parkinson's disease, bacterial infections and fungal infections .
    Evernic Acid
  • HY-N2036
    Mosloflavone
    1 Publications Verification

    		 TNF Receptor Enterovirus Bacterial Infection
    Mosloflavone is a flavonoid isolated from Scutellaria baicalensis Georgi with ?anti-EV71 activity. Mosloflavone? inhibits VP2 virus replication and protein expression during the initial stage of virus infection and inhibits viral VP2 capsid protein synthesis. Mosloflavone is a promising biocide and inhibits P. aeruginosa virulence and biofilm formation.
    Mosloflavone
  • HY-W041080
    3,5-Di-tert-butylphenol

    		Fungal Reactive Oxygen Species (ROS) Bacterial Infection
    3,5-Di-tert-butylphenol is an volatile organic compound with anti-biofilm and antifungal activities. 3,5-Di-tert-butylphenol induces accumulation of reactive oxygen species (ROS) in C. albicans cells. 3,5-Di-tert-butylphenol also has antibacterial activities .
    3,5-Di-tert-butylphenol
  • HY-42034
    Hydroquinine

    Dihydroquinine

    		 Bacterial Parasite Reactive Oxygen Species (ROS) Protein Arginine Deiminase Infection
    Hydroquinine (Dihydroquinine) is an anti-bacterial agent that inhibits both Gram-positive and Gram-negative bacteria. Hydroquinine inhibits the growth of multidrug-resistant pseudomonas aeruginosa via the suppression of the arginine deiminase pathway genes. Hydroquinine inhibits Plasmodium falciparum and Plasmodium berghei. Hydroquinine displays anti-malarial and demelanizing activities. Hydroquinine effectively induces specific RND-type efflux pump systems in Pseudomonas aeruginosa, particularly the MexCD-OprJ and MexXY efflux pumps. Hydroquinine inhibits Pseudomonas aeruginosa adhesion and biofilm formation. Hydroquinine serves as a precursor for derivatives such as C9 epihydroquinine, 9-acetoxy-10,11-dihydroquinine, and 10,11-dihydroquinine monohydrochloride .
    Hydroquinine
  • HY-N4285
    Negletein

    5,6-Dihydroxy-7-methoxyflavone

    		 TNF Receptor Interleukin Related Reactive Oxygen Species (ROS) Keap1-Nrf2 Amyloid-β Infection Neurological Disease Inflammation/Immunology Cancer
    Negletein (5,6-Dihydroxy-7-methoxyflavone) is a flavone found in Scutellaria. Negletein shows anti-inflammatory activity via inhibiting TNF-α and IL-1β with IC50 values of 16.4 and 6.4 μM, respectively. Negletein can activate Nrf2 and inhibit ROS production. Negletein can enhance the neuroprotective effect of nerve growth factor. Negletein can inhibit amyloid beta-peptide release and accumulation. Negletein can inhibit pathogens biofilms formation. Negletein can be used for the researches of cancer, infection, inflammation and neurological disease, such as colon cancer and Alzheimer's disease .
    Negletein
  • HY-W012572
    D-Histidine

    		Mitochondrial Metabolism Bacterial Infection Metabolic Disease
    D-Histidine is an anti-biofilm agent that targets bacterial quorum sensing systems (such as RhlI/RhlR pathway) and has antibacterial activity. D-Histidine works by non-covalently binding to bacterial regulatory factors or copper ion complexes, selectively inhibiting bacterial biofilm formation and motility. D-Histidine downregulates quorum sensing-related gene expression, reduces the synthesis of virulence factors (such as alginate and proteases), and interferes with bacterial membrane stability, inhibiting biofilm formation, promoting the disintegration of mature biofilms, and enhancing antibiotic sensitivity. D-Histidine is also an efficient catalyst for the salt-induced peptide formation (SIPF) reaction, which promotes the condensation of amino acids to form dipeptides (such as dialanine and dilysine) by forming a complex with copper ions (Cu 2+) .
    D-Histidine
  • HY-N2947
    Boeravinone B

    		P-glycoprotein Infection Inflammation/Immunology
    Boeravinone B, a dual inhibitor of NorA bacterial efflux pump of Staphylococcus aureus and human P-Glycoprotein, reduces the biofilm formation and intracellular invasion of bacteria. Boeravinone B act as anti-aging and anti-apoptosis phyto-molecules during oxidative stress .
    Boeravinone B
  • HY-107780
    Cyclic-di-GMP

    c-di-GMP; cyclic diguanylate; 5GP-5GP

    		 STING Endogenous Metabolite Cancer
    Cyclic-di-GMP is a STING agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic-di-GMP has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP can be used in cancer research .
    Cyclic-di-GMP
  • HY-103249
    Reutericyclin

    Reutericycline

    		 Bacterial Infection Metabolic Disease
    Reutericyclin (Reutericycline) is an orally active antibacterial and anti-obesity agent that selectively inhibits Gram-positive bacteria. By selectively dissipating transmembrane potential, Reutericyclin exerts non-lytic bactericidal or bacteriostatic activity against pathogens such as Clostridium difficile and Staphylococcus aureus, and rapidly kills vegetative cells and spores of Clostridium difficile. Reutericyclin possesses favorable properties including resistance to enzymatic hydrolysis, iron-chelating function, and poor absorption by colonic epithelium. Reutericyclin not only eradicates staphylococcal biofilms and inhibits drug-resistant strains, but also counteracts Risperidone (HY-11018)-induced weight gain by inducing changes in gut microbiota composition and restoring energy utilization efficiency. Reutericyclin can be used in research related to Clostridium difficile infection, Risperidone-induced weight gain, and staphylococcal superficial skin infections .
    Reutericyclin
  • HY-107780B
    Cyclic-di-GMP diammonium
    Maximum Cited Publications
    9 Publications Verification

    c-di-GMP diammonium; cyclic diguanylate diammonium; 5GP-5GP diammonium

    		 STING Endogenous Metabolite Cancer
    Cyclic-di-GMP diammonium is a STING agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic-di-GMP diammonium has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP diammonium can be used in cancer research .
    Cyclic-di-GMP diammonium
  • HY-77785
    2-Amino-5-chlorobenzophenone
    1 Publications Verification

    5-Chloro-2-aminobenzophenone

    		 Drug Intermediate Infection Neurological Disease
    2-Amino-5-chlorobenzophenone (5-Chloro-2-aminobenzophenone) is a chemical intermediate. Derivatives of 2-Amino-5-chlorobenzophenone serve as skeletal muscle relaxants. 2-Amino-5-chlorobenzophenone acts as a starting material for the synthesis of anti-biofilm 2-amino-5-chlorobenzophenone Schiff bases. 2-Amino-5-chlorobenzophenone is applicable to research related to bacterial infections .\n
    2-Amino-5-chlorobenzophenone
  • HY-W015490S
    1,4-Naphthoquinone-d6

    		Isotope-Labeled Compounds DNA/RNA Synthesis NF-κB Monoamine Oxidase TNF Receptor Bacterial Infection Inflammation/Immunology Cancer
    1,4-Naphthoquinone-d6 is the deuterium labeled 1,4-Naphthoquinone. 1,4-Naphthoquinone is an inhibitor with broad-spectrum inhibitory activity targeting DNA polymerase, NF-κB and monoamine oxidase (MAO-A/B), with antibacterial and anti-biofilm efficacy. 1,4-Naphthoquinone is a competitive inhibitor of MAO-B (Ki=1.4 μM) and a non-competitive inhibitor of MAO-A (Ki=7.7 μM). 1,4-Naphthoquinone inhibits DNA polymerase pol α, β, γ, δ, ε, λ with IC50 ranging from 5.57-128 μM. 1,4-Naphthoquinone inhibits tumor cell proliferation, induces apoptosis and necrosis, and has anti-angiogenic and anti-inflammatory activities by inducing oxidative stress, depleting glutathione (GSH), inhibiting DNA polymerase-mediated DNA synthesis and blocking NF-κB nuclear translocation. 1,4-Naphthoquinone can be used in anti-bacterial , anti-tumor and anti-inflammatory studies, including inhibition of melanoma and colon cancer cell growth and endothelial cell function, as well as LPS-induced inflammation models .
    1,4-Naphthoquinone-d6
  • HY-W010155R
    Tryptophol (Standard)

    Indole-3-ethanol (Standard)

    		 Reference Standards Endogenous Metabolite Apoptosis Caspase Bacterial Infection Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology
    Tryptophol (Standard) (Indole-3-ethanol (Standard)) is an analytical standard of Tryptophol (HY-W010155). This product is intended for use in research and analytical applications.Tryptophol is an aromatic alcohol and secondary metabolite produced by microorganisms. Tryptophol induces Apoptosis and cleavage of caspase-8. Tryptophol inhibits Cunninghamella blakesleeana biofilm. Tryptophol has anti-phage infection, biofilm formation regulation, anti-inflammatory, hemolytic, sleep induction, temperature change, seizure susceptibility and immune regulation activities. Tryptophol is used in the research of African trypanosomiasis, sleep disorders, epilepsy.
    Tryptophol (Standard)
  • HY-N3831
    Epimedokoreanin B

    		Bacterial Apoptosis Infection Inflammation/Immunology Cancer
    Epimedokoreanin B is a natural flavonoid with anticancer, anti-inflammatory and antibacterial effects. Epimedokoreanin B inhibits the growth of lung cancer cells through endoplasmic reticulum stress-mediated apoptosis accompanied by autophagosome accumulation. Epimedokoreanin B is an anti-periodontitis agent that inhibits gingipains and Porphyromonas gingivalis growth and biofilm formation .
    Epimedokoreanin B
  • HY-W750342
    Tryptophol-d4

    Indole-3-ethanol-d4

    		 Isotope-Labeled Compounds Endogenous Metabolite Apoptosis Caspase Bacterial Infection Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology
    Tryptophol-d4 (Indole-3-ethanol-d4) is the deuterium labeled Tryptophol (HY-W010155). Tryptophol is an aromatic alcohol and secondary metabolite produced by microorganisms. Tryptophol induces apoptosis and cleavage of caspase-8. Tryptophol inhibits Cunninghamella blakesleeana biofilm. Tryptophol has anti-phage infection, biofilm formation regulation, anti-inflammatory, hemolytic, sleep induction, temperature change, seizure susceptibility and immune regulation activities. Tryptophol is used in the research of African trypanosomiasis, sleep disorders, epilepsy .
    Tryptophol-d4
  • HY-P1884
    LL-37, acetylated,amidated

    		Bacterial Infection
    LL-37, acetylated, amidated is a cathelicidin peptide LL-37 acetylated on the N-terminus and amidated on the C-terminus. The single human cathelicidin peptide LL-37 has antimicrobial and anti-biofilm activity against multiple Gram-positive and Gram-negative human pathogens, and has wound-healing effects on the host .
    LL-37, acetylated,amidated
  • HY-N11709
    Theasaponin E1

    		Apoptosis VEGFR ATM/ATR PTEN Akt mTOR HIF/HIF Prolyl-Hydroxylase NF-κB Notch Cholinesterase (ChE) Amyloid-β γ-secretase Ferroptosis Fungal Infection Neurological Disease Metabolic Disease Cancer
    Theasaponin E1 is an orally effective tea saponin. Theasaponin E1 inhibits the proliferation of cancer cells by activating apoptosis. Theasaponin E1 inhibits angiogenesis in ovarian cancer cells and HUVECs by reducing the expression of VEGF. Theasaponin E1 upregulates the phosphorylation level of ATM protein and the expression level of PTEN protein in cancer cells, decreases the phosphorylation levels of Akt, mTOR, p70S6K and 4E-BP1 proteins, downregulates the expression of HIF-1α and NF-κB, and reduces the protein expression of Notch ligands Dll4 and Jagged1. Theasaponin E1 exerts neuroprotective effects by inhibiting the activity of acetylcholinesterase, activating α-secretase and neprilysin, reducing the concentration of Aβ, and inhibiting the activities of β-secretase and γ-secretase. Theasaponin E1 exhibits toxic effects on cancer cells and quinone reductase-inducing activity, and inhibits tumor growth in vivo. Theasaponin E1 induces ferroptosis in Pomacea canaliculata by synergistically disrupting cholesterol homeostasis and sphingolipid metabolism. Theasaponin E1 possesses anti-biofilm activity against Candida albicans. Theasaponin E1 can be used in the research of ovarian cancer, obesity, Alzheimer's disease and fungal infections .
    Theasaponin E1
  • HY-W041080R
    3,5-Di-tert-butylphenol (Standard)

    		Reference Standards Fungal Reactive Oxygen Species (ROS) Bacterial Infection
    3,5-Di-tert-butylphenol (Standard) is the analytical standard of 3,5-Di-tert-butylphenol (HY-W041080). This product is intended for research and analytical applications. 3,5-Di-tert-butylphenol is an volatile organic compound with anti-biofilm and antifungal activities. 3,5-Di-tert-butylphenol induces accumulation of reactive oxygen species (ROS) in C. albicans cells. 3,5-Di-tert-butylphenol also has antibacterial activities.
    3,5-Di-tert-butylphenol (Standard)
  • HY-W012572A
    D-Histidine hydrochloride hydrate

    		Mitochondrial Metabolism Bacterial Infection Metabolic Disease
    D-Histidine hydrochloride hydrate is an anti-biofilm agent that targets bacterial quorum sensing systems (such as RhlI/RhlR pathway) and has antibacterial activity. D-Histidine hydrochloride hydrate works by non-covalently binding to bacterial regulatory factors or copper ion complexes, selectively inhibiting bacterial biofilm formation and motility. D-Histidine hydrochloride hydrate downregulates quorum sensing-related gene expression, reduces the synthesis of virulence factors (such as alginate and proteases), and interferes with bacterial membrane stability, inhibiting biofilm formation, promoting the disintegration of mature biofilms, and enhancing antibiotic sensitivity. D-Histidine hydrochloride hydrate is also an efficient catalyst for the salt-induced peptide formation (SIPF) reaction, which promotes the condensation of amino acids to form dipeptides (such as dialanine and dilysine) by forming a complex with copper ions (Cu 2+) .
    D-Histidine hydrochloride hydrate
  • HY-P11165
    DRGN-1

    		Bacterial Infection
    DRGN-1 is an antimicrobial peptide. DRGN-1 exhibits potent antimicrobial and anti-biofilm activities, inhibiting both Gram-negative and Gram-positive bacteria, with an EC50 range of 0.50-4.62 μM. DRGN-1 exerts its antimicrobial effect by disrupting bacterial membrane permeability and slightly depolarizing the membrane potential. DRGN-1 inhibits the formation of biofilms of single bacterial species and mixed species of Pseudomonas aeruginosa and Staphylococcus aureus. DRGN-1 can significantly promote the healing of uninfected and mixed biofilm-infected mouse wounds. DRGN-1 can be used for the study of infections .
    DRGN-1
  • HY-107780A
    Cyclic-di-GMP sodium

    c-di-GMP sodium; cyclic diguanylate sodium; 5GP-5GP sodium

    		 STING Endogenous Metabolite Cancer
    Cyclic-di-GMP sodium is a STING agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic-di-GMP sodium has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP sodium can be used in cancer research .
    Cyclic-di-GMP sodium
  • HY-17594R
    Oxyclozanide (Standard)

    		Oxidative Phosphorylation Reference Standards Parasite Bacterial Fungal Infection
    Oxyclozanide (Standard) is the analytical standard of Oxyclozanide. This product is intended for research and analytical applications. Oxyclozanide is an orally active salicylanilide anthelmintic agent that mainly acts by uncoupling oxidative phosphorylation in flukes. Oxyclozanide shows good anti-adenovirus, anti-biofilm, antifungal, and antibacterial activity .
    Oxyclozanide (Standard)
  • HY-P5706
    HG2

    		Bacterial Infection Inflammation/Immunology
    HG2 is a fast-acting antimicrobial peptide. HG2 shows anti-biofilm and anti-inflammatory activities. HG2 is active against Gram-positive pathogens, especially against MRSA strains (MIC: 16-32 μg/mL). HG2 can bind to bacterial lipids and reduces ATP concentration in S. aureus MRSA USA300 cells .
    HG2
  • HY-178952
    Anti-infective agent 12

    		Bacterial Infection
    Anti-infective agent 12 (Compound A09) is a competitive inhibitor of type I signal peptidease (SPase I), with an IC50 of 4.475 μM and a Kd of 16.3 μM. Anti-infective agent 12 has the ability to disrupt bacterial membranes and remove biofilms. Anti-infective agent 12 exhibits potent bactericidal activity against Gram-positive bacteria, with MIC values of 4, 4, 8, and 8 μg/mL for Staphylococcus aureus, Enterococcus faecalis, Enterococcus faecium, and Streptococcus suis, respectively. Anti-infective agent 12 remains effective against multi-drug resistant strains, but has weaker activity against Gram-negative bacteria (such as Escherichia coli and Salmonella), with MIC values > 64 μg/mL. Anti-infective agent 12 has low hemolytic activity and shows significant efficacy in mouse skin infection models .
    Anti-infective agent 12
  • HY-119726A
    Fosmanogepix (tautomerism)

    APX001 (tautomerism); E1211 (tautomerism)

    		 Fungal Infection Inflammation/Immunology
    Fosmanogepix tautomerism (APX001 tautomerism) is a broad-spectrum and orally active anti-invasive fungal compound. Fosmanogepix tautomerism targets the conserved Gwt1 enzyme required for the localization of glycosylphosphatidylinositol-anchored mannoproteins in fungi, and inhibition prevents proper localization of cell wall mannoproteins, thereby impairing cell wall integrity, biofilm formation, germ tube formation, and fungal growth. Fosmanogepix tautomerism can be used to study invasive fungal infections .
    Fosmanogepix (tautomerism)
  • HY-W015490R
    1,4-Naphthoquinone (Standard)

    		Reference Standards DNA/RNA Synthesis NF-κB Monoamine Oxidase TNF Receptor Bacterial Infection Inflammation/Immunology Cancer
    1,4-Naphthoquinone is an inhibitor with broad-spectrum inhibitory activity targeting DNA polymerase, NF-κB and monoamine oxidase (MAO-A/B), with antibacterial and anti-biofilm efficacy. 1,4-Naphthoquinone is a competitive inhibitor of MAO-B (Ki=1.4 μM) and a non-competitive inhibitor of MAO-A (Ki=7.7 μM). 1,4-Naphthoquinone inhibits DNA polymerase pol α, β, γ, δ, ε, λ with IC50 ranging from 5.57-128 μM. 1,4-Naphthoquinone inhibits tumor cell proliferation, induces apoptosis and necrosis, and has anti-angiogenic and anti-inflammatory activities by inducing oxidative stress, depleting glutathione (GSH), inhibiting DNA polymerase-mediated DNA synthesis and blocking NF-κB nuclear translocation. 1,4-Naphthoquinone can be used in anti-bacterial , anti-tumor and anti-inflammatory studies, including inhibition of melanoma and colon cancer cell growth and endothelial cell function, as well as LPS-induced inflammation models .
    1,4-Naphthoquinone (Standard)
  • HY-175539
    DNA gyrase/Topo IV-IN-2

    		Bacterial Topoisomerase DNA/RNA Synthesis Infection
    DNA gyrase/Topo IV-IN-2 (Compound AK19) is an antibacterial agent with IC50 values of 0.783 μM and 7.136 μM against E. coli DNA gyrase and topoisomerase IV, respectively. DNA gyrase/Topo IV-IN-2 exhibits broad-spectrum antibacterial efficacy against both Gram-positive and Gram-negative pathogens. DNA gyrase/Topo IV-IN-2 can inhibit the biofilms of B. subtilis and MRSA, with an MIC of 1.9 μM against both B. subtilis and MRSA. DNA gyrase/Topo IV-IN-2 can be used in research related to anti-drug-resistant bacterial drugs .
    DNA gyrase/Topo IV-IN-2
  • HY-161069
    Anti-infective agent 8

    		Bacterial Infection
    Anti-infective agent 8 (compound 9d) is an antibacterial agent with an MIC of 0.5 μg/mL against Staphylococcus aureus and Mycobacterium tuberculosis H37Rv. Anti-infective agent 8 has anti-biofilm activity and significantly reduces Staphylococcus aureus biofilm formation .
    Anti-infective agent 8
  • HY-168063
    Antibiofilm agent-11

    		Bacterial Infection
    Antibiofilm agent-11 (compound C12) is a xanthone derivative with anti-biofilm activity .
    Antibiofilm agent-11
  • HY-172912
    Anti-MRSA agent 27

    		Bacterial Infection
    Anti-MRSA agent 27 (compound 4a) is a potent anti-methicillin-resistant Staphylococcus aureus agent with a MIC of 0.0975 μmol/L. Anti-MRSA agent 27 disrupts MRSA biofilms and suppresses hemolytic toxin production .
    Anti-MRSA agent 27
  • HY-N0535R
    (+)-Magnoflorine chloride (Standard)

    Magnoflorine chloride (Standard); α-Magnoflorine chloride (Standard); Thalictrine chloride (Standard)

    		 Reference Standards Fungal Infection Metabolic Disease
    (+)-Magnoflorine (chloride) (Standard) is the analytical standard of (+)-Magnoflorine (chloride). This product is intended for research and analytical applications. Magnoflorine chloride (Magnoflorine chloride), an aporphine alkaloid found in Magnolia or Aristolochia, reduces the formation of C. albicans biofilm . Magnoflorine chloride has anti-fungal, anti-antidiabetic and anti-oxidative activity .
    (+)-Magnoflorine chloride (Standard)
  • HY-169191
    Quorum sensing-IN-8

    		Bacterial Infection
    Quorum sensing-IN-8 (compound 5e) has anti-biofilm activity. Quorum sensing-IN-8 can be used for the study of antimicrobial resistance .
    Quorum sensing-IN-8
  • HY-157143
    Antibacterial agent 164

    		Bacterial Infection
    Antibacterial agent 164 (compound 2a) is an antibacterial and antibiofilm agent. Antibacterial agent 164 inhibits S. aureus and B. subtilis (MIC of 0.09 mM), and also exhibits strong anti-B. Subtilis biofilm formation .
    Antibacterial agent 164
  • HY-W012572R
    D-Histidine (Standard)

    		Reference Standards Mitochondrial Metabolism Bacterial Infection Metabolic Disease
    D-Histidine (Standard) is the analytical standard of D-Histidine (HY-W012572). This product is intended for research and analytical applications. D-Histidine is an anti-biofilm agent that targets bacterial quorum sensing systems (such as RhlI/RhlR pathway) and has antibacterial activity. D-Histidine works by non-covalently binding to bacterial regulatory factors or copper ion complexes, selectively inhibiting bacterial biofilm formation and motility. D-Histidine downregulates quorum sensing-related gene expression, reduces the synthesis of virulence factors (such as alginate and proteases), and interferes with bacterial membrane stability, inhibiting biofilm formation, promoting the disintegration of mature biofilms, and enhancing antibiotic sensitivity. D-Histidine is also an efficient catalyst for the salt-induced peptide formation (SIPF) reaction, which promotes the condensation of amino acids to form dipeptides (such as dialanine and dilysine) by forming a complex with copper ions (Cu 2+) .
    D-Histidine (Standard)
  • HY-155546
    Antimicrobial agent-22

    		Bacterial Infection
    Antimicrobial agent-22 (THI 6c) is a multi-target broad-spectrum antibacterial agent. Antimicrobial agent-22 has low cytotoxicity, hemolytic property, rapid bactericidal ability and good anti-biofilm activity .
    Antimicrobial agent-22
  • HY-P10968
    KT2

    		Bacterial Antibiotic Infection
    KT2 is a cationic amphipathic antibacterial peptide. KT2 can completely kill cells of E. coli O157:H7. KT2 has potent anti-biofilm activity and prevents biofilm formation of E. coli O157:H7. KT2 significantly binds to bacterial surface LPS and interacts with the lipids of liposomes with great penetration capability into bacterial cells, followed by bond to DNA and other cytoplasmic membrane .
    KT2
  • HY-161803
    Anti-MRSA agent 12

    		Antibiotic Bacterial Infection
    Anti-MRSA agent 12 (Compound SM-5) is an antibiotic, which exhibits antibacterial activity against Staphylococcus aureus, S. epidermidis and Escherichia coli with MIC of 7.81, 7.81 and 62.5 μM. Anti-MRSA agent 12 inhibits the methicillin-resistant S. aureus (MRSA) through inhibition of biofilm formation .
    Anti-MRSA agent 12
  • HY-155722
    Mtb-IN-5

    		Bacterial Infection
    Mtb-IN-5 (compound (-)17j) is an isoxazole, with anti-Mycobacterium tuberculosis (Mtb) activity. Mtb-IN-4 inhibits Mtb respiration and biofilm formation in macrophage, and enhances antibiotic isoniazid (INH) inhibition against INH-resistant Mtb mutant .
    Mtb-IN-5
  • HY-178493
    Anti-MRSA agent 37

    		Bacterial Infection
    Anti-MRSA agent 37 (Compound 5B) is an antibacterial agent against methicillin-resistant Staphylococcus aureus (MRSA) (MIC=0.25-0.5 μg/mL). Anti-MRSA agent 37 inhibits biofilm formation, disrupts cell wall integrit, attacks cell membrane and induces oxidative stress. Anti-MRSA agent 37 is promising for research of MRSA-related diseases such as skin infections .
    Anti-MRSA agent 37
  • HY-178108
    Anti-MRSA agent 35

    		Bacterial Penicillin-binding protein (PBP) Fungal Infection
    Anti-MRSA agent 35 (Compound 6b) is an anti-MRSA agent. Anti-MRSA agent 35 significantly inhibits MRSA biofilm formation, suppresses penicillin-binding protein (PBP2a) expression and induces mecA virulence gene mutation. Anti-MRSA agent 35 has potent bactericidal and fungicidal activities with MIC50s of 7.8-31.25 μg/mL for gram positive bacteria, gram-negative bacteria and Fungi. .
    Anti-MRSA agent 35
  • HY-P5709
    HG4

    		Bacterial Infection Inflammation/Immunology
    HG4 is a fast-acting antimicrobial peptide. HG4 shows anti-biofilm and anti-inflammatory activities. HG4 is active against Gram-positive pathogens, especially against MRSA strains (MIC: 32-64 μg/mL). HG4 can bind to bacterial lipids and reduces ATP concentration in S. aureus MRSA USA300 cells .
    HG4
  • HY-N2947R
    Boeravinone B (Standard)

    		Reference Standards P-glycoprotein Infection Inflammation/Immunology
    Boeravinone B (Standard) is the analytical standard of Boeravinone B. This product is intended for research and analytical applications. Boeravinone B, a dual inhibitor of NorA bacterial efflux pump of Staphylococcus aureus and human P-Glycoprotein, reduces the biofilm formation and intracellular invasion of bacteria. Boeravinone B act as anti-aging and anti-apoptosis phyto-molecules during oxidative stress .
    Boeravinone B (Standard)
  • HY-146327
    PqsR/LasR-IN-1

    		Bacterial Antibiotic Infection
    PqsR/LasR-IN-1 (compound 2a) is a potent PqsR and LasR systems inhibitor. PqsR/LasR-IN-1 has anti-virulence activity against Pseudomonas aeruginosa. PqsR/LasR-IN-1 can reduce production of biofilm, pyocyanin, and rhamnolipids in PA .
    PqsR/LasR-IN-1
  • HY-173594
    TarO-IN-1

    		Bacterial Infection
    TarO-IN-1 (Compound 18a) is a TarO inhibitor and has antibacterial activity. TarO-IN-1 has β-lactam sensitizing and anti-biofilm activities against MRSA. TarO-IN-1 can be used for research of β-lactam resistance .
    TarO-IN-1

Inquiry Online

Your information is safe with us. * Required Fields.

Salutation

  

Country or Region *

Applicant Name *

 

Organization Name *

Department *

     

Email Address *

 

Product Name *

Cat. No.

  

Requested quantity *

Phone Number *

     

Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent: