Anti-MRSA agent 33 iodide
Anti-MRSA agent 33 iodide is an anti-Methicillin (HY-121544)-resistant Staphylococcus aureus (MRSA) agent, with MIC values of 2-4 μg/mL. Anti-MRSA agent 33 iodide demonstrates effective biofilm eradication and minimal cytotoxicity toward mammalian cells. Anti-MRSA agent 33 iodide specifically binds to phosphatidylglycerol (PG) on bacterial membranes, leading to membrane disruption, excessive production of ROS, and metabolic collapse, ultimately resulting in bacterial cell death. Anti-MRSA agent 33 iodide reduces bacterial load in a murine skin infection model.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Fòrmula: C35H35IN6O
- Peso molecular:682.60
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Actividad biológica
Descripciòn
In Vitro
Anti-MRSA agent 33 iodide (Compound IV4) (16-20 h) shows antibacterial activity against S. aureus ATCC 29213, MRSA N315, 10 clinical MRSA isolates (M22, M17, M16, M23, M14, M13, M11, M21, M12 and M20), with MIC values of 2-4 μg/mL[1].
Anti-MRSA agent 33 iodide (8-32 μg/mL, 3-6 h) combines rapid bactericidal activity against S. aureus ATCC 29213 and MRSA N315, with low resistance induction potential[1].
Anti-MRSA agent 33 iodide (2-16 μg/mL, 3-6 h) has the effect of disrupting bacterial biofilms (S. aureus ATCC 29213 and MRSA N315)[1].
Anti-MRSA agent 33 iodide (2-128 μg/mL) demonstrates superior safety profiles with IC50 values of 22.48 and 27.45 μg/mL for RAW 264.7 and NIH 3T3 cells, respectively[1].
Anti-MRSA agent 33 iodide (4-64 μg/mL) specifically binds to phosphatidylglycerol (PG) on bacterial membranes, leading to membrane disruption, excessive production of ROS, and metabolic collapse, ultimately resulting in bacterial cell death[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:MRSA N315
-
Concentration:4, 8, 16, 32, 64 μg/mL
-
Incubation Time:4 h
-
Result:Showed complete membrane destruction and bacterial death.
-
Cell Line:MRSA N315
-
Concentration:8 μg/mL
-
Incubation Time:2 h
-
Result:Inhibited the expression of amaP, qoxA, qoxB, and atpB.
Upregulated the levels of ahpC.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:KM mice aged 6-8 weeks were subcutaneously inoculated with MRSA suspension (6 × 108 cfu/mL)[1]
-
Dosage:5, 10 mg/kg
-
Administration:Subcutaneously administered for a single dose after MRSA suspension 4 h
-
Result:Showed smooth skin surface at the infection site and prevented obvious inflammatory cell infiltration in both the epidermis and dermis.
Reduced IL-6 and TNF-α levels.
Showed no pathological changes (inflammation/necrosis/hemorrhage) in the heart, lungs, spleen, or kidneys, with normal tissue architecture and cell arrangement.
Chemical Information
-
Peso molecular 682.60
-
Fòrmula C35H35IN6O
-
SMILES
C[N+](CCCCN1C2=CC=CC=C2C3=C1C4=NC5=C(C(N4CC3)=O)C=CC=C5)(CC6=NC=CC=C6)CC7=CC=CC=N7.[I-]
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-MRSA agent 33 iodide Related Classifications
HY-175295A Related Classifications
Powered by Bioz