Anti-MRSA agent 33 iodide
Anti-MRSA agent 33 iodide is an anti-Methicillin (HY-121544)-resistant Staphylococcus aureus (MRSA) agent, with MIC values of 2-4 μg/mL. Anti-MRSA agent 33 iodide demonstrates effective biofilm eradication and minimal cytotoxicity toward mammalian cells. Anti-MRSA agent 33 iodide specifically binds to phosphatidylglycerol (PG) on bacterial membranes, leading to membrane disruption, excessive production of ROS, and metabolic collapse, ultimately resulting in bacterial cell death. Anti-MRSA agent 33 iodide reduces bacterial load in a murine skin infection model.
For research use only. We do not sell to patients.
- Formula: C35H35IN6O
- Molecular Weight:682.60
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Anti-MRSA agent 33 iodide (Compound IV4) (16-20 h) shows antibacterial activity against S. aureus ATCC 29213, MRSA N315, 10 clinical MRSA isolates (M22, M17, M16, M23, M14, M13, M11, M21, M12 and M20), with MIC values of 2-4 μg/mL[1].
Anti-MRSA agent 33 iodide (8-32 μg/mL, 3-6 h) combines rapid bactericidal activity against S. aureus ATCC 29213 and MRSA N315, with low resistance induction potential[1].
Anti-MRSA agent 33 iodide (2-16 μg/mL, 3-6 h) has the effect of disrupting bacterial biofilms (S. aureus ATCC 29213 and MRSA N315)[1].
Anti-MRSA agent 33 iodide (2-128 μg/mL) demonstrates superior safety profiles with IC50 values of 22.48 and 27.45 μg/mL for RAW 264.7 and NIH 3T3 cells, respectively[1].
Anti-MRSA agent 33 iodide (4-64 μg/mL) specifically binds to phosphatidylglycerol (PG) on bacterial membranes, leading to membrane disruption, excessive production of ROS, and metabolic collapse, ultimately resulting in bacterial cell death[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MRSA N315
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Concentration:4, 8, 16, 32, 64 μg/mL
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Incubation Time:4 h
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Result:Showed complete membrane destruction and bacterial death.
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Cell Line:MRSA N315
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Concentration:8 μg/mL
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Incubation Time:2 h
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Result:Inhibited the expression of amaP, qoxA, qoxB, and atpB.
Upregulated the levels of ahpC.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:KM mice aged 6-8 weeks were subcutaneously inoculated with MRSA suspension (6 × 108 cfu/mL)[1]
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Dosage:5, 10 mg/kg
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Administration:Subcutaneously administered for a single dose after MRSA suspension 4 h
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Result:Showed smooth skin surface at the infection site and prevented obvious inflammatory cell infiltration in both the epidermis and dermis.
Reduced IL-6 and TNF-α levels.
Showed no pathological changes (inflammation/necrosis/hemorrhage) in the heart, lungs, spleen, or kidneys, with normal tissue architecture and cell arrangement.
Chemical Information
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Molecular Weight 682.60
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Formula C35H35IN6O
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SMILES
C[N+](CCCCN1C2=CC=CC=C2C3=C1C4=NC5=C(C(N4CC3)=O)C=CC=C5)(CC6=NC=CC=C6)CC7=CC=CC=N7.[I-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-MRSA agent 33 iodide Related Classifications
HY-175295A Related Classifications
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