Antibacterial agent 331
Antibacterial agent 331 is an antibacterial agent with anti-biofilm activity. Antibacterial agent 331 exhibits activity against a variety of Gram-positive and Gram-negative bacteria. Antibacterial agent 331 eliminates MRSE 62 and promotes the repair of infected wounds in mouse models. Antibacterial agent 331 can be used for research on infections.
For research use only. We do not sell to patients.
- Formula: C26H29FN6O5S
- Molecular Weight:556.61
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Antibacterial agent 331 (compound A4) (24 h) potently inhibits the growth of standard Gram-positive bacterial strains (Listeria monocytogenes CMCC54004, Staphylococcus aureus ATCC29213, Enterococcus faecalis BNCC186300) and Gram-negative bacterial strains (Salmonella typhimurium SL1344, Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 15442), with MIC values ranging from <0.0625 to 0.25 μg/mL[1].
Antibacterial agent 331 (24 h) potently inhibits the growth of clinically isolated drug-resistant Gram-positive strains (MRSA 62, L970, L971; MRSE 61, 62, 63; VRE 11, 12, 13), with MIC values ranging from 0.125 to 16 μg/mL[1].
Antibacterial agent 331 (8 μg/mL; 24 h) eliminates 58.1% of mature MRSE 62 biofilms[1].
Antibacterial agent 331 (24 h) exhibits low cytotoxicity against L929 mouse fibroblasts, with a CC50 value > 128 μg/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:L929 mouse fibroblast cells
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Concentration:/
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Incubation Time:24 h
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Result:Did not significantly reduce L929 cell viability, with a CC50 value >128 μg/mL.
Antibacterial agent 331 (50-100 mg/kg; p.o.; once daily; for 8 consecutive days) is well tolerated in Kunming mice, with no adverse effects on body weight, organ function or histomorphology observed[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Kunming mice (male, 5-6 weeks of age, 18-22 g for biosafety study; male, 20±2 g for skin infection study)[1]
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Dosage:2× MIC
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Administration:local; once daily; 9 days
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Result:Reduced MRSE 62 bacterial load by approximately 3.1 log10 relative to controls.
Enhanced wound healing, with a higher wound contraction rate on day 3 compared to controls and reference groups.
Induced minimal inflammatory cell infiltration and near-normal cell morphology in treated tissue, unlike control and ciprofloxacin groups with obvious inflammatory cell infiltration and tissue abnormalities.
Chemical Information
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Molecular Weight 556.61
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Formula C26H29FN6O5S
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SMILES
NC1=CC(NC(SCCCCC(N2CCN(CC2)C3=C(C=C4C(C(C(O)=O)=CN(C4=C3)C5CC5)=O)F)=O)=N1)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antibacterial agent 331 Related Classifications
HY-182056 Related Classifications
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- Antibacterial agent 331
- Antibacterial agent331
- Antibacterial agent-331
- Bacterial
- methicillin
- Staphylococcus epidermidis
- Listeria monocytogenes CMCC54004
- MRSE 62
- Escherichia coli ATCC 25922
- mouse model
- Salmonella typhimurium SL1344
- Staphylococcus aureus ATCC29213
- Enterococcus faecalis BNCC186300
- L929 mouse fibroblast cells
- Pseudomonas aeruginosa ATCC 15442
- Inhibitor
- inhibitor
- inhibit