Antibacterial agent 331 

Antibacterial agent 331 is an antibacterial agent with anti-biofilm activity. Antibacterial agent 331 exhibits activity against a variety of Gram-positive and Gram-negative bacteria. Antibacterial agent 331 eliminates MRSE 62 and promotes the repair of infected wounds in mouse models. Antibacterial agent 331 can be used for research on infections^[1].

Antibacterial agent 331 (compound A4) (24 h) potently inhibits the growth of standard Gram-positive bacterial strains (Listeria monocytogenes CMCC54004, Staphylococcus aureus ATCC29213, Enterococcus faecalis BNCC186300) and Gram-negative bacterial strains (Salmonella typhimurium SL1344, Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 15442), with MIC values ranging from <0.0625 to 0.25 μg/mL^[1].
Antibacterial agent 331 (24 h) potently inhibits the growth of clinically isolated drug-resistant Gram-positive strains (MRSA 62, L970, L971; MRSE 61, 62, 63; VRE 11, 12, 13), with MIC values ranging from 0.125 to 16 μg/mL^[1].
Antibacterial agent 331 (8 μg/mL; 24 h) eliminates 58.1% of mature MRSE 62 biofilms^[1].
Antibacterial agent 331 (24 h) exhibits low cytotoxicity against L929 mouse fibroblasts, with a CC₅₀ value > 128 μg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antibacterial agent 331 (2× MIC; local administration; once daily; for 9 consecutive days) significantly reduces the bacterial load in Kunming mice infected with MRSE 62, promotes the healing of infected skin wounds, and induces only extremely mild associated inflammatory responses^[1].
Antibacterial agent 331 (50-100 mg/kg; p.o.; once daily; for 8 consecutive days) is well tolerated in Kunming mice, with no adverse effects on body weight, organ function or histomorphology observed^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

556.61

C₂₆H₂₉FN₆O₅S

NC1=CC(NC(SCCCCC(N2CCN(CC2)C3=C(C=C4C(C(C(O)=O)=CN(C4=C3)C5CC5)=O)F)=O)=N1)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Du H, et al. Design, synthesis and biological evaluation of novel fluoroquinolone-uracil hybrids against methicillin-resistant Staphylococcus Epidermidis (MRSE) infections. Bioorg Chem. 2026;173:109657.  [Content Brief]