D-Histidine hydrochloride hydrate
Based on 1 Customer Validation
D-Histidine hydrochloride hydrate is an anti-biofilm agent that targets bacterial quorum sensing systems (such as RhlI/RhlR pathway) and has antibacterial activity. D-Histidine hydrochloride hydrate works by non-covalently binding to bacterial regulatory factors or copper ion complexes, selectively inhibiting bacterial biofilm formation and motility. D-Histidine hydrochloride hydrate downregulates quorum sensing-related gene expression, reduces the synthesis of virulence factors (such as alginate and proteases), and interferes with bacterial membrane stability, inhibiting biofilm formation, promoting the disintegration of mature biofilms, and enhancing antibiotic sensitivity. D-Histidine hydrochloride hydrate is also an efficient catalyst for the salt-induced peptide formation (SIPF) reaction, which promotes the condensation of amino acids to form dipeptides (such as dialanine and dilysine) by forming a complex with copper ions (Cu2+).
For research use only. We do not sell to patients.
- Purity: 99.46%
- CAS No.: 328526-86-9
- Formula: C6H12ClN3O3
- Molecular Weight:209.63
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Chemical Information
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CAS No. 328526-86-9
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Appearance Solid
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Molecular Weight 209.63
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Formula C6H12ClN3O3
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Color White to off-white
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Sequence
D-His
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Sequence Shortening
D-His
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : 50 mg/mL (238.52 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Zhang H, et al. D-histidine combated biofilm formation and enhanced the effect of amikacin against Pseudomonas aeruginosa in vitro. Arch Microbiol. 2024 Mar 11;206(4):148. https://pubmed.ncbi.nlm.nih.gov/38462558/ [Content Brief]
[2]. Fitz D, et al. The catalytic effect of L- and D-histidine on alanine and lysine peptide formation. J Inorg Biochem. 2008 Dec;102(12):2097-102. [Content Brief]
[3]. Ikeda Y, et al. L-histidine but not D-histidine attenuates brain edema following cryogenic injury in rats. Acta Neurochir Suppl. 2000;76:195-7. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 4.7703 mL | 23.8515 mL | 47.7031 mL | 119.2577 mL |
| 5 mM | 0.9541 mL | 4.7703 mL | 9.5406 mL | 23.8515 mL | |
| 10 mM | 0.4770 mL | 2.3852 mL | 4.7703 mL | 11.9258 mL | |
| 15 mM | 0.3180 mL | 1.5901 mL | 3.1802 mL | 7.9505 mL | |
| 20 mM | 0.2385 mL | 1.1926 mL | 2.3852 mL | 5.9629 mL | |
| 25 mM | 0.1908 mL | 0.9541 mL | 1.9081 mL | 4.7703 mL | |
| 30 mM | 0.1590 mL | 0.7951 mL | 1.5901 mL | 3.9753 mL | |
| 40 mM | 0.1193 mL | 0.5963 mL | 1.1926 mL | 2.9814 mL | |
| 50 mM | 0.0954 mL | 0.4770 mL | 0.9541 mL | 2.3852 mL | |
| 60 mM | 0.0795 mL | 0.3975 mL | 0.7951 mL | 1.9876 mL | |
| 80 mM | 0.0596 mL | 0.2981 mL | 0.5963 mL | 1.4907 mL | |
| 100 mM | 0.0477 mL | 0.2385 mL | 0.4770 mL | 1.1926 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
D-Histidine hydrochloride hydrate Related Classifications
HY-W012572A Related Classifications
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