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Cat. No.: HY-178212

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Antibacterial agent 292

Antibacterial agent 292 is a 3-pyrazolylindole derivative. Antibacterial agent 292 is an anti-bacterial agent. Antibacterial agent 292 shows potent inhibitory activity against Xanthomonas oryzae pv oryzae (Xoo) and Xanthomonas axonopodis pv citri (Xac), with EC₅₀ values of 2.54 and 3.49 μg/mL. Antibacterial agent 292 can suppress biofilm formation, bacterial motility, and extracellular polysaccharide production, induce morphological alterations and promote ROS accumulation, ultimately triggers bacterial apoptosis. Antibacterial agent 292 down-regulates the expression of genes associated with the type VI secretion system (T6SS). Antibacterial agent 292 can be used in rice bacterial blight and citrus canker.

For research use only. We do not sell to patients.

CAS No.: 3065015-86-0
Formula: C₂₄H₂₅ClN₆O
Molecular Weight:448.95

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Antibacterial agent 292 Chemical Structure

CAS No.: 3065015-86-0

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
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Bioz

Biological Activity

Description

In Vitro

Antibacterial agent 292 (Compound P16) (3.125-25 μg/mL) inhibits growth of Xoo and Xac cells^[1].
Antibacterial agent 292 (3.125-12.5 μg/mL) increases ROS accumulation and induces apoptosis in Xoo and Xac cells^[1].
Antibacterial agent 292 (3.125-50 μg/mL) inhibits biofilm formation, exopolysaccharide content and motility in Xoo and Xac cells^[1].
Antibacterial agent 292 reduces the expressions of vgrG, hcp, and clpV in T6SS in Xoo cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3065015-86-0
Molecular Weight 448.95
Formula C₂₄H₂₅ClN₆O
SMILES

ClC1=CC=C(CN(CC2)CCN2CC(NC3=CC(C4=CNC5=C4C=CC=C5)=NN3)=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wu G, et al. Design, Synthesis, and Antibacterial Activity Evaluation and Mechanism of 1-H-Indole-3-pyrazolamide Derivatives Containing Piperazine. J Agric Food Chem. 2025 Sep 24;73(38):24404-24415. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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