3065015-86-0
Chemical Structure
Antibacterial agent 292
- CAS 番号: 3065015-86-0
- Formula:C24H25ClN6O
- Molecular Weight:448.95
SMILES: ClC1=CC=C(CN(CC2)CCN2CC(NC3=CC(C4=CNC5=C4C=CC=C5)=NN3)=O)C=C1
Biological Activity: Antibacterial agent 292 is a 3-pyrazolylindole derivative. Antibacterial agent 292 is an anti-bacterial agent. Antibacterial agent 292 shows potent inhibitory activity against Xanthomonas oryzae pv oryzae (Xoo) and Xanthomonas axonopodis pv citri (Xac), with EC50 values of 2.54 and 3.49 μg/mL. Antibacterial agent 292 can suppress biofilm formation, bacterial motility, and extracellular polysaccharide production, induce morphological alterations and promote ROS accumulation, ultimately triggers bacterial apoptosis. Antibacterial agent 292 down-regulates the expression of genes associated with the type VI secretion system (T6SS). Antibacterial agent 292 can be used in rice bacterial blight and citrus canker[1].
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Antibacterial agent 292 | Antibacterial agent 292 is a 3-pyrazolylindole derivative. Antibacterial agent 292 is an anti-bacterial agent. Antibacterial agent 292 shows potent inhibitory activity against Xanthomonas oryzae pv oryzae (Xoo) and Xanthomonas axonopodis pv citri (Xac), with EC50 values of 2.54 and 3.49 μg/mL. Antibacterial agent 292 can suppress biofilm formation, bacterial motility, and extracellular polysaccharide production, induce morphological alterations and promote ROS accumulation, ultimately triggers bacterial apoptosis. Antibacterial agent 292 down-regulates the expression of genes associated with the type VI secretion system (T6SS). Antibacterial agent 292 can be used in rice bacterial blight and citrus canker. | |||||||||||||||||||||
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