76 Results for "

phosphorylation metabolism

" in MedChemExpress (MCE) Product Catalog:
Products (76)

76 Results for "phosphorylation metabolism" in MCE Product Catalog:

31
Sodium dichloroacetate
Sodium dichloroacetate
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31 Publications Verification
Cat. No.: HY-Y0445A
CAS No.: 2156-56-1
Target:  

PDK-1 NKCC PDHK Reactive Oxygen Species (ROS) Apoptosis

Research Areas:  

Cancer

Sodium dichloroacetate is an orally active pyruvate dehydrogenase kinase (PDK) inhibitor. Sodium dichloroacetate also stimulates pyruvate dehydrogenase (PDH) activity and works as a Na +-K +-2Cl − cotransporter (NKCC) inhibitor. Sodium dichloroacetate prevents the phosphorylation of the E1α subunit of PDC, promoting the entry of pyruvate into the mitochondria for oxidative metabolism, reducing lactate production, and simultaneously increasing the production of reactive oxygen species (ROS). Sodium dichloroacetate inhibits tumor cell proliferation and induces apoptosis. Sodium dichloroacetate is promising for research of cancers .
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8
Rafoxanide
Rafoxanide
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8 Cited Publications
Cat. No.: HY-17598
CAS No.: 22662-39-1
Target:  

Oxidative Phosphorylation Parasite p38 MAPK Raf Apoptosis

Research Areas:  

Infection Cancer

Rafoxanide is a poent, orally active halogenated salicylaniline agent with antiparasitic activity. Rafoxanide interferes with energy metabolism in trematodes by uncoupling oxidative phosphorylation. Rafoxanide is also found to be a potent inhibitor of the BRAF V600E mutant protein, which is important in colorectal cancer. Rafoxanide can be used for the control of infestation with Hemonchus species or Fasciola species in sheep and cattle as well as Oestrus ovis in sheep. Rafoxanide can also be used for cancer research .
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7
Acetyl Coenzyme A trisodium
Acetyl Coenzyme A trisodium
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7 Cited Publications
Cat. No.: HY-113596
CAS No.: 102029-73-2
Purity:  99.22%
Synonyms: Acetyl-CoA trisodium
Category:  

Natural Products Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Oxidative Phosphorylation Endogenous Metabolite Autophagy

Acetyl-coenzyme A (Acetyl-CoA) trisodium is a membrane-impermeant central metabolic intermediate, participates in the TCA cycle and oxidative phosphorylation metabolism. Acetyl-coenzyme A trisodium, regulates various cellular mechanisms by providing (sole donor) acetyl groups to target amino acid residues for post-translational acetylation reactions of proteins. Acetyl Coenzyme A trisodium is also a key precursor of lipid synthesis .
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7
Acetyl coenzyme A lithium
Acetyl coenzyme A lithium
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7 Cited Publications
Cat. No.: HY-113596A
CAS No.: 32140-51-5
Purity:  97%
Synonyms: Acetyl-CoA lithium
Acetyl-coenzyme A (Acetyl-CoA) lithium is a membrane-impermeant central metabolic intermediate, participates in the TCA cycle and oxidative phosphorylation metabolism. Acetyl-coenzyme A lithium, regulates various cellular mechanisms by providing (sole donor) acetyl groups to target amino acid residues for post-translational acetylation reactions of proteins. Acetyl Coenzyme A lithium is also a key precursor of lipid synthesis .
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5
Kaempferol 3-O-β-D-glucuronide
Kaempferol 3-O-β-D-glucuronide
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5 Cited Publications
Cat. No.: HY-N7176
CAS No.: 22688-78-4
Synonyms: Kaempferol-3-glucuronide; Kaempferol-3-O-glucuronide
Category:  

Flavonols other families Flavonoids Microorganisms Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology

Target:  

Interleukin Related

Kaempferol 3-O-β-D-glucuronide (Kaempferol-3-glucuronide) is a metabolite of kaempferol that can be taken orally and has anti-inflammatory properties. Kaempferol 3-O-β-D-glucuronide can activate AKT/GSK3β phosphorylation and improve glucose metabolism .
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4
Chemerin-9 (149-157) TFA
Chemerin-9 (149-157) TFA
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4 Cited Publications
Cat. No.: HY-P1844A
Target:  

Chemerin Receptor Akt ERK Reactive Oxygen Species (ROS) Amyloid-β

Research Areas:  

Inflammation/Immunology

Chemerin-9 (149-157) TFA is a potent agonist of chemokine-like receptor 1 (CMKLR1) . Chemerin-9 (149-157) TFA has anti-inflammatory activity. Chemerin-9 (149-157) TFA stimulates phosphorylation of Akt and ERK as well as ROS production. Chemerin-9 (149-157) TFA ameliorates Aβ1-42-induced memory impairmen. Chemerin-9 (149-157) TFA regulates immune responses, adipocyte differentiation, and glucose metabolism .
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4
Chemerin-9 (149-157)
Chemerin-9 (149-157)
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4 Cited Publications
Cat. No.: HY-P1844
CAS No.: 676367-27-4
Target:  

Chemerin Receptor Akt ERK Reactive Oxygen Species (ROS) Amyloid-β

Research Areas:  

Inflammation/Immunology

Chemerin-9 (149-157) is a potent agonist of chemokine-like receptor 1 (CMKLR1) . Chemerin-9 (149-157) has anti-inflammatory activity. Chemerin-9 (149-157) stimulates phosphorylation of Akt and ERK as well as ROS production. Chemerin-9 (149-157) ameliorates Aβ1-42-induced memory impairmen. Chemerin-9 (149-157) regulates immune responses, adipocyte differentiation, and glucose metabolism .
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3
p-Synephrine
p-Synephrine
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3 Cited Publications
Cat. No.: HY-113236
CAS No.: 614-35-7
Purity:  98.04%
Category:  

Citrus × aurantium Linnaeus Rutaceae Plants Endogenous metabolite Alkaloids Monophenols Other Alkaloids Other Diseases Phenols Disease Research Fields

Target:  

Adrenergic Receptor AMPK GLUT p38 MAPK NF-κB

p-Synephrine is an orally active alkaloid dietary supplement without indirect sympathomimetic activity or cardiovascular stimulatory activity. p-Synephrine stimulates AMPK phosphorylation and mediates Glut4 translocation to increase glucose consumption and lactate production in skeletal muscle cells. p-Synephrine also downregulates the p38 MAPK and NF-κB signaling pathways to inhibit pro-inflammatory cytokine production and alter oxidative metabolism. p-Synephrine exhibits low subchronic toxicity in mice. p-Synephrine can be applied to research related to systemic inflammatory response syndrome, obesity, and type 2 diabetes .
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2
Buprofezin
Buprofezin
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2 Cited Publications
Cat. No.: HY-B0831
CAS No.: 69327-76-0
Target:  

Environmental Pollutants Reactive Oxygen Species (ROS) Oxidative Phosphorylation

Research Areas:  

Others

Buprofezin is a broad-spectrum insecticide and chitin synthesis inhibitor that targets developmental stage coleopteran pests.Buprofezin promotes the conversion of energy metabolism from the aerobic tricarboxylic acid (TCA) cycle and oxidative phosphorylation to anaerobic glycolysis. Buprofezin also promotes the production of reactive oxygen species (ROS) by inhibiting cytochrome c oxidase .
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2
Momordicine I
Momordicine I
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2 Cited Publications
Cat. No.: HY-122949
CAS No.: 91590-76-0
Purity:  ≥97.0%
Category:  

Triterpenes Terpenoids Cucurbitaceae Plants Momordica charantia Linn.

Target:  

Oxidative Phosphorylation AMPK Keap1-Nrf2 Src Akt Apoptosis NO Synthase mTOR PI3K Autophagy Reactive Oxygen Species (ROS) Endogenous Metabolite Mitochondrial Metabolism NF-κB c-Met/HGFR DGK Interleukin Related STAT

Momordicine I is a cucurbitane-type triterpenoids. Momordicine I suppresses glioma growth by promoting apoptosis and impairing mitochondrial oxidative phosphorylation. Momordicine I inhibits glycolysis, lipid metabolism, induces autophagy in HNC cells to suppress head and neck cancer growth. Momordicine I alleviates isoproterenol-induced cardiomyocyte hypertrophy through suppression of PLA2G6 and DGK-ζ. Momordicine I exerts its cardiovascular benefits by upregulating nitric oxide, inhibiting the activity of angiotensin-converting enzyme (ACE), activating the PI3K/Akt pathway, reducing oxidative stress and inflammation. Momordicine I inhibits AKT1, IL-6, and SRC, suggesting its potential application in type 2 diabetes .
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1
Queuine
Queuine
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1 Cited Publications
Cat. No.: HY-N10574
CAS No.: 72496-59-4
Category:  

Alkaloids Microorganisms Pyrrole Alkaloids

Target:  

Bacterial

Queuine is a selective substrate for tRNA guanine transglycosylase (TGT) and can be incorporated into eukaryotic tRNA. Queuine promotes tRNA modification, affecting mitochondrial function and Warburg metabolic phenotype. If Queuine is deficient, aerobic glycolysis can be enhanced, oxidative phosphorylation can be inhibited, and Warburg metabolism can be promoted, accompanied by increased ammonia and lactate production and increased lactate dehydrogenase activity. Queuine can be used for autoimmune diseases (such as experimental models of multiple sclerosis) and cancer metabolic regulation, and its deficiency is associated with low tRNA modification in tumor cells .
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1
Peonidin 3-O-glucoside chloride
Peonidin 3-O-glucoside chloride
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1 Cited Publications
Cat. No.: HY-W040127
CAS No.: 6906-39-4
Category:  

Anthocyans Flavonoids Vitis vinifera cv. Zalema Metabolic Disease Plants Vitaceae Disease Research Fields

Target:  

Insulin Receptor

Peonidin 3-O-glucoside chloride is an agonist of the free fatty acid receptor FFAR1 and Glucokinase. Peonidin 3-O-glucoside chloride enhances insulin secretion of pancreatic beta cells and increases glucose uptake by liver cells. Peonidin 3-O-glucoside chloride activates FFAR1, promotes the phosphorylation of related proteins in the insulin secretion pathway, and increases the expression of FFAR1. In liver cells, Peonidin 3-O-glucoside chloride activates GK and regulates proteins associated with carbohydrate metabolism. Peonidin 3-O-glucoside chloride can be used in diabetes research .
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1
4-Methyl-2-oxopentanoic acid
4-Methyl-2-oxopentanoic acid
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1 Cited Publications
Cat. No.: HY-W012722
CAS No.: 816-66-0
Synonyms: α-Ketoisocaproic acid
Category:  

Human Gut Microbiota Metabolites Microorganisms Immune System Disorder Ketones, Aldehydes, Acids Disease markers Endogenous metabolite

Target:  

Endogenous Metabolite Autophagy mTOR SOD

4-Methyl-2-oxopentanoic acid (α-Ketoisocaproic acid) is a metabolite of L-leucine and is involved in energy metabolism. 4-Methyl-2-oxopentanoic acid increases endoplasmic reticulum stress, promotes lipid accumulation in preadipocytes and insulin resistance by impairing mTOR and autophagy signaling pathways. 4-Methyl-2-oxopentanoic acid also causes oxidative damage, leading to cognitive deficits, inhibits α-ketoglutarate dehydrogenase activity, acts as an oxidative phosphorylation uncoupler and metabolic inhibitor. 4-Methyl-2-oxopentanoic acid acts as a nutrient signal and stimulates skeletal muscle protein synthesis. 4-Methyl-2-oxopentanoic acid can be used in the study of maple syrup urine disease .
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1
Dephospho-CoA
Dephospho-CoA
0 Images
1 Cited Publications
Cat. No.: HY-137899
CAS No.: 3633-59-8
Purity:  96.00%
Category:  

Human Gut Microbiota Metabolites Natural Products Other Diseases Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite

Dephospho-CoA is a key intermediate in the biosynthesis of coenzyme A (CoA), which is catalyzed to form CoA by GTP-dependent Dephospho-CoA kinase (DPCK). Dephospho-CoA completes the final synthetic step of CoA via phosphorylation and participates in energy metabolism and cellular signal transduction. Dephospho-CoA can be used in studies involving cancer (e.g., regulation of cell proliferation) and metabolic diseases (e.g., mitochondrial dysfunction) .
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1
N-Desmethyltamoxifen hydrochloride
N-Desmethyltamoxifen hydrochloride
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1 Cited Publications
Cat. No.: HY-129099A
CAS No.: 15917-65-4
Purity:  99.93%
Category:  

Disease Research Fields Cancer

Target:  

PKC Estrogen Receptor/ERR Drug Metabolite

N-Desmethyltamoxifen hydrochloride is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen. N-Desmethyltamoxifen hydrochloride is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation .
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1
Queuine dihydrochloride
Queuine dihydrochloride
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1 Cited Publications
Cat. No.: HY-N10574A
CAS No.: 86496-18-6
Category:  

Alkaloids Microorganisms Pyrrole Alkaloids

Target:  

Others

Queuine dihydrochloride is a selective substrate for tRNA guanine transglycosylase (TGT) and can be incorporated into eukaryotic tRNA. Queuine dihydrochloride promotes tRNA modification, affecting mitochondrial function and Warburg metabolic phenotype. If Queuine dihydrochloride is deficient, aerobic glycolysis can be enhanced, oxidative phosphorylation can be inhibited, and Warburg metabolism can be promoted, accompanied by increased ammonia and lactate production and increased lactate dehydrogenase activity. Queuine dihydrochloride can be used for autoimmune diseases (such as experimental models of multiple sclerosis) and cancer metabolic regulation, and its deficiency is associated with low tRNA modification in tumor cells .
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1
N-Desmethyltamoxifen
N-Desmethyltamoxifen
0 Images
1 Cited Publications
Cat. No.: HY-129099
CAS No.: 31750-48-8
Category:  

Disease Research Fields Cancer

Target:  

PKC Estrogen Receptor/ERR Drug Metabolite

N-Desmethyltamoxifen is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen. N-Desmethyltamoxifen is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation .
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Ginsenoside F2
Ginsenoside F2
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Cat. No.: HY-125848
CAS No.: 62025-49-4
Purity:  99.95%
Category:  

Panax ginseng C. A. Meyer Triterpenes Terpenoids Plants Endogenous metabolite Disease Research Fields Araliaceae Cancer

Target:  

Apoptosis AMPK PPAR p38 MAPK PI3K Akt GSK-3 Reactive Oxygen Species (ROS) SOD Caspase

Ginsenoside F2 is an orally active bioactive compound that participates in the regulation of metabolism and inflammation. Ginsenoside F2 promotes the phosphorylation of AMPK and ACC, binds to PPARγ, inhibits the phosphorylation of MAPK, activates the PI3K/AKT/GSK-3β pathway, reduces GLRX expression, and regulates lipid metabolism. Ginsenoside F2 reduces ROS production and MDA levels, restores SOD activity in cells, and alleviates oxidative stress. Ginsenoside F2 induces cell apoptosis (Apoptosis) and increases the number of cleaved caspase-3-positive cells. Ginsenoside F2 reduces body weight gain, adipose tissue weight and serum lipid levels in obese mice, and activates the hepatic AMPK signaling pathway and the expression of antioxidant enzymes. Ginsenoside F2 alleviates atopic dermatitis in mice by inhibiting inflammation and reshaping the gut microbiota . Ginsenoside F2 is applicable to research related to insulin resistance, obesity, atopic dermatitis, liver cancer, glioblastoma and glioma .
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Acetyl coenzyme A trilithium
Acetyl coenzyme A trilithium
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Cat. No.: HY-114293A
CAS No.: 75520-41-1
Synonyms: Acetyl-CoA trilithium
Category:  

Cardiovascular Disease Natural Products Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Oxidative Phosphorylation Endogenous Metabolite Autophagy

Acetyl-coenzyme A (Acetyl-CoA) trilithium is a membrane-impermeant central metabolic intermediate, participates in the TCA cycle and oxidative phosphorylation metabolism. Acetyl-coenzyme A trilithium regulates various cellular mechanisms by providing (sole donor) acetyl groups to target amino acid residues for post-translational acetylation reactions of proteins. Acetyl Coenzyme A trilithium is also a key precursor of lipid synthesis .
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Leucic acid
Leucic acid
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Cat. No.: HY-30216A
CAS No.: 498-36-2
Synonyms: α-Hydroxyisocaproic acid
Category:  

Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields

Target:  

Drug Metabolite Hydroxycarboxylic Acid Receptor (HCAR) AMPK ERK

Leucic acid (α-Hydroxyisocaproic acid) is an orally active end-product of the microbial metabolism of leucine. Leucic acid can bind to HCAR2, alters AMPK and ERK1/2 phosphorylation status, suppresses lipid synthesis, promotes catabolism, reduces adiposity, enhances lean mass and exercise capacity. Leucic acid suppresses pro-inflammatory cytokine secretion, inflammation-related gene mRNA expression. Leucic acid decreases basal protein synthesis, attenuates myotube atrophy. Leucic acid can be used for the research of obesity .
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