PDHK1-IN-1
PDHK1-IN-1 (compound 17) is a selective inhibitor of PDHK1 (IC50=1.5 μM) with anticancer activity. PDHK1 negatively regulates the pyruvate dehydrogenase complex (PDC), limiting the tricarboxylic acid (TCA) cycle and oxidative phosphorylation. Overexpression of PDHK1 can shift the metabolism towards an increased glycolysis dependence (Warburg effect). PDHK1-IN-1 can inhibit the phosphorylation of the PDC E1α Ser232 recognition site of PDHK1 and the phosphorylation of Ser293.
For research use only. We do not sell to patients.
- Formula: C14H11BrClNO4S
- Molecular Weight:404.66
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
PDHK1[1]
Chemical Information
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Molecular Weight 404.66
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Formula C14H11BrClNO4S
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SMILES
ClC1=CC=C(C(S(=O)(NC2=C(C=CC(C(O)=O)=C2)Br)=O)=C1)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PDHK1-IN-1 Related Classifications
HY-170838 Related Classifications
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