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Cat. No.: HY-145306

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DX3-234

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DX3-234 is an oxidative phosphorylation (OXPHOS) inhibitor. DX3-234 shows significant tumor suppression in the Pan02 syngeneic model of pancreatic cancer.

For research use only. We do not sell to patients.

Purity: 98.96%
CAS No.: 2941323-59-5
Formula: C₂₅H₃₅N₅O₆S₂
Molecular Weight:565.71

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

DX3-234 Chemical Structure

CAS No.: 2941323-59-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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- Cellular Effect
Chemical Information
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Biological Activity

Description

DX3-234 is an oxidative phosphorylation (OXPHOS) inhibitor. DX3-234 shows significant tumor suppression in the Pan02 syngeneic model of pancreatic cancer^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
MIA PaCa-2	IC₅₀	>10 μM Compound: 64; DX3-234	Cytotoxicity against human MIA PaCa-2 cells assessed as inhibition of cell growth incubated for 3 days in galactose-containing medium by MTT assay Cytotoxicity against human MIA PaCa-2 cells assessed as inhibition of cell growth incubated for 3 days in galactose-containing medium by MTT assay	[PMID: 34982568]
MIA PaCa-2	IC₅₀	0.02 μM Compound: 64; DX3-234	Cytotoxicity against human MIA PaCa-2 cells assessed as inhibition of cell growth incubated for 3 days in glucose-containing medium by MTT assay Cytotoxicity against human MIA PaCa-2 cells assessed as inhibition of cell growth incubated for 3 days in glucose-containing medium by MTT assay	[PMID: 34982568]
MIA PaCa-2	IC₅₀	0.07 μM Compound: 64; DX3-234	Cytotoxicity against human MIA PaCa-2 cells assessed as inhibition of cell growth incubated for 7 days in glucose-containing medium by MTT assay Cytotoxicity against human MIA PaCa-2 cells assessed as inhibition of cell growth incubated for 7 days in glucose-containing medium by MTT assay	[PMID: 34982568]
MIA PaCa-2	IC₅₀	42.6 nM Compound: 64; DX3-234	Inhibition of oxidative phosphorylation in human MIA PaCa-2 cells assessed as reduction in ATP production incubated for 24 hrs in galactose-containing medium by CellTiter-glo luminescence assay Inhibition of oxidative phosphorylation in human MIA PaCa-2 cells assessed as reduction in ATP production incubated for 24 hrs in galactose-containing medium by CellTiter-glo luminescence assay	[PMID: 34982568]

Chemical Information

CAS No. 2941323-59-5
Appearance Solid
Molecular Weight 565.71
Formula C₂₅H₃₅N₅O₆S₂
Color White to off-white
SMILES

O=S(C1=CC=C(C=C1)S(=O)(N2C[C@@H](CCC2)C(N3CCN(CC3)C4=NC(C(C)C)=NO4)=O)=O)(C5CCC5)=O
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Xue D, et al. Discovery and Lead Optimization of Benzene-1,4-disulfonamides as Oxidative Phosphorylation Inhibitors. J Med Chem. 2022;65(1):343-368. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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DX3-234

MCE Bioactive Compound Library

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DX3-234 Related Classifications

HY-145306 Related Classifications