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Cat. No.: HY-W037817

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Dimethyl L-glutamate

Name: Dimethyl L-glutamate
Brand: MedChemExpress
SKU: HY-W037817
Availability: PreOrder

(Synonyms: Dimethyl glutamate)

Dimethyl L-glutamate (Dimethyl glutamate) is a NMDA receptor ligand and a cell membrane-permeable glutamate precursor. Dimethyl L-glutamate binds to NMDA receptors to regulate osteoblast maturation, and promotes osteoblast proliferation, adhesion, extracellular calcium deposition, and alkaline phosphatase activity. Dimethyl L-glutamate replenishes the glutamate pool in insulin-secreting β cells. Dimethyl L-glutamate can be used in research related to bone defects and non-insulin-dependent diabetes mellitus.

For research use only. We do not sell to patients.

CAS No.: 6525-53-7
Formula: C₇H₁₃NO₄
Molecular Weight:175.18

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Dimethyl L-glutamate Chemical Structure

CAS No.: 6525-53-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]^[2]^[3]^[4]^[5]

NMDA Receptor

All iGluR Isoforms :

In Vitro

Dimethyl L-glutamate (Dimethyl glutamate) (20-100 μg/mL; overnight, 2 h) enhances protein adsorption on chitosan/microfibrillated cellulose-based composite scaffolds (S1-S7) in a concentration-dependent manner, with the highest adsorption at 20 μg/mL and optimal performance on S7 scaffolds^[1].
Dimethyl L-glutamate (50-100 μg/mL; 1-7 days) treated chitosan/microfibrillated cellulose-based composite scaffolds (S1-S7) enhance MG63 cell viability in a time-dependent manner^[1].
Dimethyl L-glutamate (50-100 μg/mL; 7 days) treated chitosan/microfibrillated cellulose-based composite scaffolds (S1-S7) enhance early-stage osteogenic differentiation of MG63 cells^[1].
Dimethyl L-glutamate (50-100 μg/mL; 7 days) treated chitosan/microfibrillated cellulose-based composite scaffolds (S1-S7) enhance late-stage osteogenic differentiation of MG63 cells^[1].
Dimethyl L-glutamate (5 mM) fully restores Glucose (D-Glucose) (HY-B0389)-stimulated insulin secretion in GC1-silenced INS-1E β-cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

human osteoblast-like MG63 cells
Concentration:

50-100 μg/mL (scaffold loading)
Incubation Time:

1, 3, 5, 7 days (cell culture)
Result:

Increased with longer culture duration across all scaffolds and concentrations.
Was higher on all treated scaffolds than untreated controls.

Chemical Information

CAS No. 6525-53-7
Molecular Weight 175.18
Formula C₇H₁₃NO₄
Synonyms

Dimethyl glutamate
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (282 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Mv S, et al. In vitro study of dimethyl glutamate incorporated chitosan/microfibrillated cellulose based matrix in addition of H and Zr on osteoblast cells. International journal of biological macromolecules. 2025 Feb;289:138889.

[2]. Casimir M, et al. Mitochondrial glutamate carrier GC1 as a newly identified player in the control of glucose-stimulated insulin secretion. The Journal of biological chemistry. 2009 Sep 11;284(37):25004-14.

[3]. Vetterli L, et al. Delineation of glutamate pathways and secretory responses in pancreatic islets with β-cell-specific abrogation of the glutamate dehydrogenase. Molecular biology of the cell. 2012 Oct;23(19):3851-62.

[4]. Taylor EC, et al. Synthesis of Conformationally‑Constrained Glutamate Analogues of the Antitumor Agents DDATHF, LY254155, and LY231514. J Org Chem. 1997 Aug 8;62(16):5392‑5403.

[5]. Bakkali Nadi A, et al. Effects of the methyl esters of pyruvate, succinate and glutamate on the secretory response to meglitinide analogues in rat pancreatic islets. Pharmacological research. 1996 Mar;33(3):191-4.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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Dimethyl L-glutamate

All iGluR Isoforms