6525-53-7
Chemical Structure
Dimethyl L-glutamate
Synonym(s): Dimethyl glutamate
- CAS No.: 6525-53-7
- Formula:C7H13NO4
- Molecular Weight:175.18
IUPAC Name: dimethyl L-glutamate
InChIKey: YEJSPQZHMWGIGP-YFKPBYRVSA-N
SMILES: N[C@@H](CCC(OC)=O)C(OC)=O
Biological Activity: Dimethyl L-glutamate (Dimethyl glutamate) is a NMDA receptor ligand and a cell membrane-permeable glutamate precursor. Dimethyl L-glutamate binds to NMDA receptors to regulate osteoblast maturation, and promotes osteoblast proliferation, adhesion, extracellular calcium deposition, and alkaline phosphatase activity. Dimethyl L-glutamate replenishes the glutamate pool in insulin-secreting β cells. Dimethyl L-glutamate can be used in research related to bone defects and non-insulin-dependent diabetes mellitus[1][2][3][4][5].
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Dimethyl L-glutamate | Dimethyl L-glutamate (Dimethyl glutamate) is a NMDA receptor ligand and a cell membrane-permeable glutamate precursor. Dimethyl L-glutamate binds to NMDA receptors to regulate osteoblast maturation, and promotes osteoblast proliferation, adhesion, extracellular calcium deposition, and alkaline phosphatase activity. Dimethyl L-glutamate replenishes the glutamate pool in insulin-secreting β cells. Dimethyl L-glutamate can be used in research related to bone defects and non-insulin-dependent diabetes mellitus. | |||||||||||||||||||||
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References
- [1]. Mv S, et al. In vitro study of dimethyl glutamate incorporated chitosan/microfibrillated cellulose based matrix in addition of H and Zr on osteoblast cells. International journal of biological macromolecules. 2025 Feb;289:138889.
- [2]. Casimir M, et al. Mitochondrial glutamate carrier GC1 as a newly identified player in the control of glucose-stimulated insulin secretion. The Journal of biological chemistry. 2009 Sep 11;284(37):25004-14.
- [3]. Vetterli L, et al. Delineation of glutamate pathways and secretory responses in pancreatic islets with β-cell-specific abrogation of the glutamate dehydrogenase. Molecular biology of the cell. 2012 Oct;23(19):3851-62.
- [4]. Taylor EC, et al. Synthesis of Conformationally‑Constrained Glutamate Analogues of the Antitumor Agents DDATHF, LY254155, and LY231514. J Org Chem. 1997 Aug 8;62(16):5392‑5403.
- [5]. Bakkali Nadi A, et al. Effects of the methyl esters of pyruvate, succinate and glutamate on the secretory response to meglitinide analogues in rat pancreatic islets. Pharmacological research. 1996 Mar;33(3):191-4.
