Dimethyl L-glutamate hydrochloride
Based on 1 Customer Validation
Dimethyl L-glutamate hydrochloride (Dimethyl glutamate hydrochloride) is a NMDA receptor ligand and a cell membrane-permeable glutamate precursor. Dimethyl L-glutamate hydrochloride binds to NMDA receptors to regulate osteoblast maturation, and promotes osteoblast proliferation, adhesion, extracellular calcium deposition, and alkaline phosphatase activity. Dimethyl L-glutamate hydrochloride replenishes the glutamate pool in insulin-secreting β cells. Dimethyl L-glutamate hydrochloride can be used in research related to bone defects and non-insulin-dependent diabetes mellitus.
For research use only. We do not sell to patients.
- Purity: 97.0%
- CAS No.: 23150-65-4
- Formula: C7H14ClNO4
- Molecular Weight:211.64
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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NMDA Receptor |
Dimethyl L-glutamate (20-100 μg/mL; overnight, 2 h) hydrochloride (Dimethyl glutamate hydrochloride) enhances protein adsorption on chitosan/microfibrillated cellulose-based composite scaffolds (S1-S7) in a concentration-dependent manner, with the highest adsorption at 20 μg/mL and optimal performance on S7 scaffolds[1].
Dimethyl L-glutamate (50-100 μg/mL; 1-7 days) hydrochloride treated chitosan/microfibrillated cellulose-based composite scaffolds (S1-S7) enhance MG63 cell viability in a time-dependent manner[1].
Dimethyl L-glutamate (50-100 μg/mL; 7 days) hydrochloride treated chitosan/microfibrillated cellulose-based composite scaffolds (S1-S7) enhance early-stage osteogenic differentiation of MG63 cells[1].
Dimethyl L-glutamate (50-100 μg/mL; 7 days) hydrochloride treated chitosan/microfibrillated cellulose-based composite scaffolds (S1-S7) enhance late-stage osteogenic differentiation of MG63 cells[1].
Dimethyl L-glutamate (5 mM) hydrochloride fully restores Glucose (D-Glucose) (HY-B0389)-stimulated insulin secretion in GC1-silenced INS-1E β-cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human osteoblast-like MG63 cells
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Concentration:50-100 μg/mL (scaffold loading)
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Incubation Time:1, 3, 5, 7 days (cell culture)
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Result:Increased with longer culture duration across all scaffolds and concentrations.
Was higher on all treated scaffolds than untreated controls.
Chemical Information
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CAS No. 23150-65-4
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Appearance Solid
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Molecular Weight 211.64
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Formula C7H14ClNO4
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Color White to off-white
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Synonyms
Dimethyl glutamate hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : ≥ 100 mg/mL (472.50 mM)
DMSO : 100 mg/mL (472.50 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 4.7250 mL | 23.6250 mL | 47.2500 mL | 118.1251 mL |
| 5 mM | 0.9450 mL | 4.7250 mL | 9.4500 mL | 23.6250 mL | |
| 10 mM | 0.4725 mL | 2.3625 mL | 4.7250 mL | 11.8125 mL | |
| 15 mM | 0.3150 mL | 1.5750 mL | 3.1500 mL | 7.8750 mL | |
| 20 mM | 0.2363 mL | 1.1813 mL | 2.3625 mL | 5.9063 mL | |
| 25 mM | 0.1890 mL | 0.9450 mL | 1.8900 mL | 4.7250 mL | |
| 30 mM | 0.1575 mL | 0.7875 mL | 1.5750 mL | 3.9375 mL | |
| 40 mM | 0.1181 mL | 0.5906 mL | 1.1813 mL | 2.9531 mL | |
| 50 mM | 0.0945 mL | 0.4725 mL | 0.9450 mL | 2.3625 mL | |
| 60 mM | 0.0788 mL | 0.3938 mL | 0.7875 mL | 1.9688 mL | |
| 80 mM | 0.0591 mL | 0.2953 mL | 0.5906 mL | 1.4766 mL | |
| 100 mM | 0.0473 mL | 0.2363 mL | 0.4725 mL | 1.1813 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Dimethyl L-glutamate hydrochloride Related Classifications
HY-Y0749 Related Classifications
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