2. Stem Cell/Wnt GPCR/G Protein MAPK/ERK Pathway Metabolic Enzyme/Protease Anti-infection Immunology/Inflammation PI3K/Akt/mTOR JAK/STAT Signaling
  3. Wnt Ras Endogenous Metabolite Bacterial Fungal PD-1/PD-L1 Tim3 Akt AP-1 STAT
  4. Atranorin

Atranorin is a secondary metabolite of lichens and AKT inhibitor. Atranorin possesses multiple activities such as antibacterial, anti-inflammatory, antioxidant, anti-glycation, analgesic, and anti-tumor effects. Atranorin has IC50 values for scavenging DPPH and ABTS free radicals of 117 μM and less than 10 μM, respectively. Additionally, Atranorin also exhibits effects in promoting wound healing. Atranorin can be used in the research of various diseases, including myelodysplastic syndromes, tumors, and inflammatory conditions.

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Atranorin

Atranorin Chemische Struktur

CAS. Nr. : 479-20-9

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Other Forms of Atranorin:

Atranorin Related Antibodies

Top Publications Citing Use of Products

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Beschreibung

Atranorin is a secondary metabolite of lichens and AKT inhibitor. Atranorin possesses multiple activities such as antibacterial, anti-inflammatory, antioxidant, anti-glycation, analgesic, and anti-tumor effects. Atranorin has IC50 values for scavenging DPPH and ABTS free radicals of 117 μM and less than 10 μM, respectively. Additionally, Atranorin also exhibits effects in promoting wound healing. Atranorin can be used in the research of various diseases, including myelodysplastic syndromes, tumors, and inflammatory conditions[1][2][3][4][5].

Cellular Effect
Cell Line Type Value Description References
HaCaT IC50
> 5 μM
Compound: 4
Antiproliferative activity against human HaCaT cells
Antiproliferative activity against human HaCaT cells
[PMID: 10395495]
PMNL IC50
6 μM
Compound: 4
Inhibition of LTB4 biosynthesis in A-23187-stimulated bovine PMNL cells
Inhibition of LTB4 biosynthesis in A-23187-stimulated bovine PMNL cells
[PMID: 10395494]
In Vitro

Atranorin (0.01-10 μg/mL; 3 h) protects SH-SY5Y cells from H2O2-induced cytotoxicity[1].
Atranorin (24 h) inhibits the expression of PD-L1 and TIM-3 in THP-1, KG-1 and Mono-Mac-1 cells, with the mechanism related to AKT pathway inhibition[2].
Atranorin (0-10 μg/mL; 24-72 h) suppresses the migration and invasion of A549 cells. The mechanism involves the inhibition of AP-1, Wnt, STAT pathways and RhoGTPase activity[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Atranorin Related Antibodies
In Vivo

Atranorin (10 mg/kg; intraperitoneal injection; once every 3 days; 2 weeks) exhibits antitumor activity in a mouse lung cancer model[3].
Atranorin (1-5%; topical application as an ointment; once daily; 3-21 days) promotes wound healing in a rat excisional wound model[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice aged 8 weeks old treated LLC cells[3]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection; once every 3 days; 2 weeks
Result: Significantly reduced tumor volume, tumor weight, and nuclear Ki-67 immunoreactivity.
Downregulated target genes (e.g., KITENIN, STAT, c-myc) in tumor tissues.
Animal Model: Male Wistar rats (220-260 g) with full-thickness excisional wounds created by an 8 mm biopsy punch on the back[4]
Dosage: 1% and 5% in ointment form
Administration: Topical application as an ointment; once daily; 3, 7, 14 and 21 days
Result: Reduced wound areas significantly on days 3, 7, and 14 (particularly with 5% atranorin).
Induced earlier granulation tissue formation with increased fibroblastic and vascular components.
Improved collagen deposition and organization (with more type I collagen and dense interlaced arrangement in the 5% group).
Modulated myofibroblasts differentiation (reduced early myofibroblasts in the 5% group and promoted timely apoptosis by day 21).
Molekulargewicht

374.34

Formel

C19H18O8
CAS. Nr.
Appearance

Solid

Color

White to off-white

SMILES

O=C(OC1=CC(C)=C(C(OC)=O)C(O)=C1C)C2=C(C)C=C(O)C(C=O)=C2O
Structure Classification
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Lösungsmittel & Löslichkeit
In Vitro: 

DMSO : 12.5 mg/mL (33.39 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6714 mL 13.3568 mL 26.7137 mL
5 mM 0.5343 mL 2.6714 mL 5.3427 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molaritätsrechner

  • Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Reinheit & Dokumentation
Verweise

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6714 mL 13.3568 mL 26.7137 mL 66.7842 mL
5 mM 0.5343 mL 2.6714 mL 5.3427 mL 13.3568 mL
10 mM 0.2671 mL 1.3357 mL 2.6714 mL 6.6784 mL
15 mM 0.1781 mL 0.8905 mL 1.7809 mL 4.4523 mL
20 mM 0.1336 mL 0.6678 mL 1.3357 mL 3.3392 mL
25 mM 0.1069 mL 0.5343 mL 1.0685 mL 2.6714 mL
30 mM 0.0890 mL 0.4452 mL 0.8905 mL 2.2261 mL
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Atranorin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Atranorin479-20-9WntRasEndogenous MetaboliteBacterialFungalPD-1/PD-L1Tim3AktAP-1STATPD-1/Programmed death-ligand 1T-Cell Immunoglobulin and Mucin Containing Protein-3CD366PKBProtein kinase BActivator Protein 1lung cancer modelexcisional wound modelSH-SY5YTHP-1KG-1Mono-Mac-1A549Inhibitorinhibitorinhibit

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