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Results for "

Ca2 concentration

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Calcium Channel (22) Calmodulin (5) CaMK (1) CaSR (3) CRAC Channel (2) Adrenergic Receptor (1) Akt (1) Androgen Receptor (2) Antibiotic (5) Apoptosis (12) Autophagy (8) Bacterial (6) Biochemical Assay Reagents (4) Caspase (1) CCR (1) Cholinesterase (ChE) (1) DNA/RNA Synthesis (2) Dopamine Receptor (1) Drug Derivative (1) Endogenous Metabolite (2) Environmental Pollutants (3) ERK (1) Fluorescent Dye (10) Fungal (7) G protein-coupled Bile Acid Receptor 1 (2) GnRH Receptor (1) Histamine Receptor (1) HIV (1) Insecticide (2) Insulin Receptor (1) Isotope-Labeled Compounds (2) mAChR (3) Microtubule/Tubulin (1) Mineralocorticoid Receptor (2) Na+/K+ ATPase (2) Necroptosis (2) Oxidative Phosphorylation (5) Parasite (1) Phosphatase (1) PI3K (1) Piezo Channel (1) PKA (1) PKC (2) Potassium Channel (7) Reactive Oxygen Species (ROS) (3) Reference Standards (8) SARS-CoV (1) SOD (2) Sodium Channel (3) Thyroid Hormone Receptor (3) TNF Receptor (1) TRP Channel (4)
By Research Areas:	Cancer (11) Cardiovascular Disease (14) Endocrinology (6) Infection (10) Inflammation/Immunology (9) Metabolic Disease (14) Neurological Disease (23)

By Targets:

Calcium Channel (22)

Calmodulin (5)

CaMK (1)

CaSR (3)

CRAC Channel (2)

Adrenergic Receptor (1)

Akt (1)

Androgen Receptor (2)

Antibiotic (5)

Apoptosis (12)

Autophagy (8)

Bacterial (6)

Biochemical Assay Reagents (4)

Caspase (1)

CCR (1)

Cholinesterase (ChE) (1)

DNA/RNA Synthesis (2)

Dopamine Receptor (1)

Drug Derivative (1)

Endogenous Metabolite (2)

Environmental Pollutants (3)

ERK (1)

Fluorescent Dye (10)

Fungal (7)

G protein-coupled Bile Acid Receptor 1 (2)

GnRH Receptor (1)

Histamine Receptor (1)

HIV (1)

Insecticide (2)

Insulin Receptor (1)

Isotope-Labeled Compounds (2)

mAChR (3)

Microtubule/Tubulin (1)

Mineralocorticoid Receptor (2)

Na+/K+ ATPase (2)

Necroptosis (2)

Oxidative Phosphorylation (5)

Parasite (1)

Phosphatase (1)

PI3K (1)

Piezo Channel (1)

PKA (1)

PKC (2)

Potassium Channel (7)

Reactive Oxygen Species (ROS) (3)

Reference Standards (8)

SARS-CoV (1)

SOD (2)

Sodium Channel (3)

Thyroid Hormone Receptor (3)

TNF Receptor (1)

TRP Channel (4)

By Research Areas:

Cancer (11)

Cardiovascular Disease (14)

Endocrinology (6)

Infection (10)

Inflammation/Immunology (9)

Metabolic Disease (14)

Neurological Disease (23)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Calcium Channel CRAC Channel Na+/Ca2+ Exchanger CaSR Calmodulin CaMK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N6687

Calcimycin Maximum Cited Publications 24 Publications Verification A-23187; Antibiotic A-23187	Oxidative Phosphorylation Bacterial Fungal Apoptosis Autophagy Antibiotic	Infection Inflammation/Immunology Cancer
Calcimycin (A-23187) is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin induces Ca ²⁺-dependent cell death by increasing intracellular calcium concentration. Calcimycin inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin induces apoptosis and autophagy .

HY-W009724

2-Aminoethyl diphenylborinate Maximum Cited Publications 71 Publications Verification 2-APB	Calcium Channel TRP Channel CRAC Channel	Cardiovascular Disease Inflammation/Immunology
2-Aminoethyl diphenylborinate (2-APB) is a cell-permeable inhibitor of Inositol triphosphate receptor (IP3R). 2-Aminoethyl diphenylborinate also inhibits the *store-operated Ca ²⁺* (SOC) channel and activates some TRP** channels (V1, V2 and V3). Additionally, 2-Aminoethyl diphenylborinate has inhibitory effects on vasospasm. At high concentrations, it exhibits specific anti-inflammatory and antioxidant effects in neural tissue .

HY-B0561

Spironolactone 5+ Cited Publications SC9420	Mineralocorticoid Receptor Androgen Receptor Autophagy Calcium Channel	Cardiovascular Disease Metabolic Disease Endocrinology Cancer
Spironolactone is an aldosterone antagonist that acts on the aldosterone mineralocorticoid receptor (IC₅₀=24 nM) and androgen receptor (IC₅₀=77 nM), promotes podocyte autophagy and regulates pain. Spironolactone improves hypertension-related vascular hypertrophy and remodeling by reducing angiotensin II (Ang II)-induced inflammation, reduces aldosterone-induced vascular and soft tissue calcification through PIT1-dependent signaling, and alleviates vascular dysfunction in type II diabetic mice by reducing oxidative stress and restoring NO/GC signaling; at low concentrations, it and its metabolites can interfere with aldosterone biosynthesis in the adrenal cortex and inhibit voltage-dependent *Ca ²⁺* channels to exert antihypertensive effects .

HY-D1024

Coelenterazine h 3 Publications Verification 2-Deoxycoelenterazine; CLZN-h	Calcium Channel	Neurological Disease
Coelenterazine h (2-Deoxycoelenterazine), a coelenterazine derivative, is a luminescent substrate for RLuc8. Coelenterazine h is more sensitive to Ca ²⁺, thus providing a valuable tool for measuring small changes in Ca ²⁺ concentrations (Ex/Em = 437/466 nm) .

HY-N6789

KT5720 4 Publications Verification	PKA	Neurological Disease Cancer
KT5720 is a potent, cell-permeable, specific, reversible and ATP-competitive PKA inhibitor (IC₅₀=3.3 μM). KT5720 is effective in reversing MDR1-mediated multidrug resistance. KT5720 also reduces the excitability of dorsal root ganglion (DRG) neurons by attenuating Hyperpolarization-activated cyclic nucleotide-gated (HCN) channel activity and reducing intracellular Ca2 ⁺ concentrations. KT5720 can be used in the study of haematological malignancies as well as HCN and DRG neuron-related diseases .

HY-10007

NPS-2143 25+ Cited Publications SB-262470A	CaSR	Metabolic Disease
NPS-2143 (SB-262470A), an orally active calcilytic agent, is a selective and potent calcium ion-sensing receptor (CaSR) antagonist. NPS-2143 (SB-262470A) blocks increases in cytoplasmic Ca ²⁺ concentrations (IC₅₀=43 nM) elicited by activating the Ca ²⁺ receptor in HEK 293 cells expressing the human Ca ²⁺ receptor .

HY-114252

Strophanthidin 1 Publications Verification	Na+/K+ ATPase	Cardiovascular Disease
Strophanthidin is a naturally available cardiac glycoside . Strophanthidin 0.1 and 1 nmol/L increases and 1~100 μmol/L inhibits the Na+/K+-ATPase activities, but Strophanthidin 10 and 100 nmol/L does not affect Na+/K+-ATPase activities in cardiac sarcolemmal . Strophanthidin increases both diastolic and systolic intracellular Ca ²⁺ concentration .

HY-13103

NS 11021 3 Publications Verification	Potassium Channel	Others
NS 11021 is a potent and specific Ca ²⁺-activated big-conductance K ⁺ Channels (KCa1.1 channels) activator. NS 11021 at concentrations above 0.3 μM activates KCa1.1 in a concentration-dependent manner by parallelshifting the channel activation curves to more negative potentials .

HY-14229

TGR5 Receptor Agonist 3 Publications Verification CCDC	G protein-coupled Bile Acid Receptor 1 Calcium Channel	Metabolic Disease
TGR5 Receptor Agonist (CCDC), a potent Takeda G protein-coupled receptor 5 (TGR5; GPCR19) agonist, shows improved potency in the U2-OS cells and melanophore cells with pEC₅₀s of 6.8 and 7.5, respectively. TGR5 Receptor Agonist can induce peripheral and central hypersensitivity to bladder distension in mice, and increase intracellular *Ca ²⁺* concentration. TGR5 Receptor Agonist can also reduces food intake and improves insulin responsiveness, in diet-induced obese mice. TGR5 Receptor Agonist can be used to research diabetes, bladder hypersensitivity and anti-obesity .

HY-103306

Ryanodine 5+ Cited Publications	Environmental Pollutants Calcium Channel	Neurological Disease
Ryanodine is a cell permeant ryanodine receptor modulator. Ryanodine can either stimulate or inhibit Ryanodine-mediated Ca ²⁺ release depending on its concentrations. Poisonous diterpenoid found in Ryania speciosa.

HY-136409

N-Decanoyl-L-homoserine lactone C10-HSL	Bacterial Reactive Oxygen Species (ROS)	Infection
N-decanoyl-L-homoserine lactone (C10-HSL) is a N-acyl-homoserine lactone (AHL) N-decanoyl-L-homoserine lactone can inhibit primary root growth in Arabidopsis. N-decanoyl-L-homoserine lactone triggers a transient and immediate increase in the concentrations of cytosolic free Ca ²⁺ and reactive oxygen species (ROS), increases the activity of mitogen-activated protein kinase 6 (MPK6), and induces nitric oxide (NO) production in Arabidopsis roots .

HY-10171

NPS-2143 hydrochloride 25+ Cited Publications SB-262470A hydrochloride	CaSR	Metabolic Disease
NPS-2143 hydrochloride (SB-262470A hydrochloride), an orally active calcilytic agent, is a selective and potent calcium ion-sensing receptor (CaSR) antagonist. NPS-2143 hydrochloride (SB-262470A hydrochloride) blocks increases in cytoplasmic Ca ²⁺ concentrations (IC₅₀=43 nM) elicited by activating the Ca ²⁺ receptor in HEK 293 cells expressing the human Ca ²⁺ receptor .

HY-N2500

Deoxypodophyllotoxin	Microtubule/Tubulin Apoptosis Autophagy	Infection Cardiovascular Disease Cancer
Deoxypodophyllotoxin (DPT), a derivative of podophyllotoxin, is a lignan with potent antimitotic, anti-inflammatory and antiviral properties isolated from Anthriscus sylvestris. Deoxypodophyllotoxin, targets the microtubule, has a major impact in oncology not only as anti-mitotics but also as potent inhibitors of angiogenesis . Deoxypodophyllotoxin induces cell autophagy and apoptosis . Deoxypodophyllotoxin evokes increase of intracellular Ca ²⁺ concentrations in DRG neurons .

HY-B0596

Taltirelin 1 Publications Verification TA-0910	Thyroid Hormone Receptor Apoptosis	Neurological Disease Endocrinology
Taltirelin (TA-0910) is an orally effective analogue of thyrotropin releasing hormone (TRH) and a TRH receptor (TRH-R) superagonist (IC₅₀ at 910 nM). Taltirelin can cross the blood-brain barrier. Taltirelin stimulates an increase in cytosolic Ca ²⁺ concentration (Ca ²⁺ release) with an EC₅₀ value of 36 nM. Taltirelin increases cell viability and reduces apoptosis in SH-SY5Y cells and primary rat mesencephalic neurons treated with MPP+ (HY-W008719) or Rotenone (HY-B1756). Taltirelin has neuroprotective effects in both cellular and animal models of Parkinson's disease. Taltirelin alleviates fatigue-like behavior in mouse models of cancer-related fatigue .

HY-101396

ICA-069673 3 Publications Verification	Potassium Channel	Neurological Disease
ICA-069673 is a KCNQ2/Q3 potassium channel activator. ICA-069673 demonstrates greater selectivity for KV7.2/7.3 over KV7.3/KV7.5, with EC₅₀s of 0.69 μM and 14.3 μM, respectively. ICA-069673 inhibits spontaneous phasic and nerve-evoked contractions in guinea pig detrusor smooth muscle (DSM). ICA-069673 also decreases the global intracellular Ca(2+) concentration in DSM cells .

HY-N0724

Mesaconitine 2 Publications Verification	TNF Receptor	Neurological Disease
Mesaconitine is a nitric oxide synthase activator. Mesaconitine drives extracellular Na ⁺ and Ca ²⁺ influx into endothelial cells, increases intracellular Na ⁺ and Ca ²⁺ concentrations, and triggers nitric oxide release. Mesaconitine is applicable for pain-related research .

HY-DY1028

Fluo-4 AM (solution)	Fluorescent Dye	Others
Fluo-4 AM (solution) is a cell-permeable Ca ²⁺ (calcium ion) indicator (Ex/Em = 485/526 nm) . Solvent and concentration: DMSO: 1 mM

HY-D0202

Arsenazo III	Fluorescent Dye	Others
Arsenazo III is an azo derivative of chromotropic acid, a metal chrome dye, a chelating agent, and a cation complexing agent. Arsenazo III forms stable 1:1 complexes with Ca ²⁺, Mg ²⁺, Sr ²⁺, Ba ²⁺, K ⁺, and Na ⁺, and its binding affinity for Ca ²⁺ depends on pH, alkali metal cation concentration, and buffer parameters. Arsenazo III serves as a colorimetric indicator for micromolar ionized Ca ²⁺ in cells .

HY-162501

Yaddle1 1 Publications Verification	Piezo Channel	Inflammation/Immunology
Yaddle1 is an agonist of the mechano-activated ion channel (Piezo1) with a half-maximal effective concentration (MEC₅₀) of 0.40 μM. Yaddle1 can significantly trigger Ca ²⁺ inflow in T cells and induce T cell activation response. Yaddle1 can be used in the study of vaccine adjuvants .

HY-N7117

1,4-Cineole	Environmental Pollutants TRP Channel	Neurological Disease
1,4-Cineole is an oxygenated monoterpene found in eucalyptus oil. 1,4-Cineole is a hTRPM8 and hTRPA1 agonist. 1,4-Cineole can increase intracellular Ca ²⁺ concentration. 1,4-Cineole exhibits anti-anxiety and anti-depression effects. 1,4-Cineole can be used for the research of neurological disease, such as depression .

HY-132191

Pradimicin A	Fungal SARS-CoV HIV	Infection
Pradimicin A is a potent antifungal agent with a *minimum inhibitory concentration* (MIC)** of 4 μg/mL against Candida rugosa. Pradimicin A exhibits antiviral activity against SARS-CoV, human immunodeficiency virus (HIV) and other enveloped viruses. Pradimicin A exerts its fungicidal activity through a *Ca ²⁺*-dependent mechanism, which induces fungal lysis. Pradimicin A can be used in research related to fungal infections, HIV infections and COVID-19 .

HY-N0642

α-L-Rhamnose monohydrate	Drug Derivative Calcium Channel	Metabolic Disease
α-L-Rhamnose monohydrate is a neutral sugar present in plants, animals, viruses and bacteria. α-L-Rhamnose monohydrate is a ligand for α-L-rhamnose-recognizing lectin sites, trigger intracellular signaling pathways. α-L-Rhamnose monohydrate induces rhaE and rhaA expression as a specific carbon source in Aspergillus nidulans, while glucose inhibits its cellular uptake. α-L-Rhamnose monohydrate induces rapid and transient increases in intracellular free *Ca ²⁺* concentration in normal human dermal fibroblasts .

HY-DY1020

Rhod-2 AM (solution)	Fluorescent Dye	Others
Rhod-2 (solution) is a high-affinity visible light excitation wavelength Ca ²⁺ fluorescent probe, Rhod-2, AM is an acetyl methyl ester derivative of Rhod-2, which has cell membrane permeability and can easily enter cells with simple culture. Once it enters the cell, it is sheared by its lactesterase to produce Rhod-2 without membrane permeability, which remains in the cell to perform the corresponding physiological functions. Maximum excitation/emission wavelength: 549/578 nm . Solvent and concentration: DMSO: 1 mM

HY-W250149

Chlorophosphonazo III	Biochemical Assay Reagents	Cancer
Chlorophosphonazo III is a cell membrane-permeable contrast agent and spectrophotometric reagent. Chlorophosphonazo III forms stable 1:1 complexes with intracellular calcium, magnesium, uranium, titanium, zirconium, thorium, scandium, equivalent actinides and protactinium. Chlorophosphonazo III generates photoacoustic signals correlated with Ca ²⁺ concentrations, which is applicable for imaging 3D tumor cell cultures and tumor spheroids. Chlorophosphonazo III exhibits no cytotoxicity, can be used for spectrophotometric detection of target ions, and the absorbance of its complexes remains stable for up to one week within the pH range of 2.2 to 7.0 .

HY-W110910

Eriochrome black T, Indicator	Biochemical Assay Reagents	Infection
Eriochrome black T, Indicator is a complexing agent for metal ions (e.g., Ca ²⁺, Mg ²⁺) and is used as an indicator in complexometric titrations. Eriochrome black T, Indicator forms colored complexes with metal ions through covalent coordination bonds, and indicates the endpoint of the titration by color change. Eriochrome black T, Indicator can be used as an anionic azo dye in photocatalytic degradation studies to evaluate the performance of photocatalysts. The reaction solution of Eriochrome black T, Indicator combined with Mg ²⁺ is initially purple. During loop-mediated isothermal amplification (LAMP), the color changes from purple to sky blue due to the consumption of Mg ²⁺ by the formation of magnesium pyrophosphate, indicating a positive reaction. The optimal concentration of Eriochrome black T, Indicator in LAMP is 60 μM, and the detection limit for Mycobacterium tuberculosis is 1 pg DNA/reaction .

HY-P11292

Caloxin 1b3	Calcium Channel	Cardiovascular Disease
Caloxin 1b3, a peptide, is a selective plasma *membrane Ca ²⁺* pump 1 (PMCA1)** inhibitor. Caloxin 1b3 significantly inhibits PMCA1 Ca ²⁺–Mg ²⁺-ATPase in the rabbit duodenal mucosa than the PMCA4 in the human erythrocyte ghosts. Caloxin 1b3 also increases cytosolic Ca ²⁺ concentration in endothelial cells. Caloxin 1b3 can be used for cardiovascular disorders research .

HY-124416

ML604086 1 Publications Verification	CCR	Inflammation/Immunology Endocrinology
ML604086 is a selective CCR8 inhibitor, inhibiting CCL1 binding to CCR8 on circulating T-cells. ML604086 inhibits CCL1 mediated chemotaxis and increases in intracellular Ca ²⁺ concentrations .

HY-160099

20-5,14-HEDE WIT003	Apoptosis Caspase DNA/RNA Synthesis PI3K Akt Reactive Oxygen Species (ROS)	Cardiovascular Disease
20-5,14-HEDE (WIT003) is an analog of 20-HETE. 20-5,14-HEDE activates PI3K/Akt signaling pathway, thereby exhibiting anti-apoptotic and cell survival promoting effects. 20-5,14-HEDE is the agonist for 20-HETE that increases intracellular Ca ²⁺ concentrations, thereby enhancing vasoconstriction .

HY-B0596A

Taltirelin acetate 1 Publications Verification TA-0910 acetate	Thyroid Hormone Receptor Apoptosis	Neurological Disease Endocrinology
Taltirelin acetate (TA-0910) is an acetate form of Taltirelin (TA-0910). Taltirelin (TA-0910) is an orally effective analogue of thyrotropin releasing hormone (TRH) and a TRH receptor (TRH-R) superagonist (IC₅₀ at 910 nM). Taltirelin can cross the blood-brain barrier. Taltirelin stimulates an increase in cytosolic Ca ²⁺ concentration (Ca ²⁺ release) with an EC₅₀ value of 36 nM. Taltirelin increases cell viability and reduces apoptosis in SH-SY5Y cells and primary rat mesencephalic neurons treated with MPP+ (HY-W008719) or Rotenone (HY-B1756). Taltirelin has neuroprotective effects in both cellular and animal models of Parkinson's disease. Taltirelin alleviates fatigue-like behavior in mouse models of cancer-related fatigue .

HY-D1024A

Coelenterazine h hydrochloride 3 Publications Verification 2-Deoxycoelenterazine hydrochloride; CLZN-h hydrochloride	Calcium Channel	Neurological Disease
Coelenterazine h (2-Deoxycoelenterazine) hydrochloride, a coelenterazine derivative, is a luminescent substrate for RLuc8. Coelenterazine h hydrochloride is more sensitive to Ca ²⁺, thus providing a valuable tool for measuring small changes in Ca ²⁺ concentrations (Ex/Em = 437/466 nm) .

HY-D1702

Mag-Fura-2 tetrapotassium	Fluorescent Dye	Others
Mag-Fura-2 tetrapotassium is a cell-impermeant UV excitable rational fluorescent Mg ²⁺/Ca ²⁺ indicator (Ex=334-360 nm, Em=510 nm). Mag-Fura-2 tetrapotassium can be used for the determination of Mg ²⁺ and Ca ²⁺ concentrations .

HY-117073

ITH12575	Calcium Channel	Neurological Disease
ITH12575, a CGP37157 derivative, is a potent and selective mNCX blocker. ITH12575 reduces Ca ²⁺ influx through CALHM1 at low micromolar concentrations .

HY-136190

TRPC6-PAM-C20	TRP Channel	Neurological Disease
TRPC6-PAM-C20 is a selective positive allosteric modulator (PAM) of TRPC6 channels. TRPC6-PAM-C20 is a potent enhancer of channel activation, enabling low basal concentrations of DAG to induce activation of the ion channel. TRPC6-PAM-C20 induces increases in intracellular Ca ²⁺ concentrations ([Ca ²⁺]i) in TRPC6-expressing HEK293 cells with an EC₅₀ of 2.37 μM. TRPC6-PAM-C20 can be used as a valuable tool to selectively exaggerate TRPC6-dependent signals .

HY-126789

DM-Nitrophen	Biochemical Assay Reagents	Metabolic Disease
DM-Nitrophen is a photolabile caged calcium compound that acts as a calcium releaser. DM-Nitrophen binds *Ca ²⁺* with high affinity and Mg ²⁺ with considerable affinity before photolysis. DM-Nitrophen releases Ca ²⁺ into the cytosol upon ultraviolet light irradiation. DM-Nitrophen induces calcium concentration pulses, triggers cytosolic calcium transients, promotes calcium-dependent exocytosis. DM-Nitrophen can be used for the research of calcium-dependent cellular processes .

HY-A0236

Aprindine	Sodium Channel Potassium Channel Calcium Channel Calmodulin	Cardiovascular Disease
Aprindine is an Ib-class anti-arrhythmic agent. Aprindine mainly exerts its effect by blocking sodium channels (I_Na), thereby reducing the excitability and conduction velocity of cardiac muscle cells. Aprindine significantly inhibits delayed potassium currents, which helps to prolong the atrial effective refractory period (AERP) and inhibit the occurrence of atrial fibrillation. Aprindine can also regulate intracellular calcium ion concentration by inhibiting Na ⁺/Ca ²⁺ exchange current (INCX), thereby further stabilizing cardiac electrical activity. Aprindine can be used for the study of atrial fibrillation (AF) and ventricular arrhythmias .

HY-P5142

ω-Hexatoxin-Hv1a ω-ACTX-Hv1; ω-Atracotoxin-HV1	Insecticide Calcium Channel Apoptosis Necroptosis	Cardiovascular Disease Neurological Disease Inflammation/Immunology
ω-Hexatoxin-Hv1a (ω-ACTX-Hv1; ω-Atracotoxin-HV1) is an orally active insecticidal neurotoxin containing an inhibitor cystine knot motif and a selective calcium channel inhibitor. ω-Hexatoxin-Hv1a blocks L-type voltage-dependent Ca ²⁺ channels and reduces intracellular calcium ion concentration, thereby decreasing apoptosis, necroptosis and oxidative stress, and promoting cell recovery and energy level elevation. ω-Hexatoxin-Hv1a causes larval paralysis and death by impairing neurotransmission in the central nervous system of insects. It shows high injectable toxicity against insects of multiple orders, but exhibits weak oral toxicity. ω-Hexatoxin-Hv1a is widely applicable to studies related to ischemia-reperfusion injury, atopic dermatitis, and ischemic injury of cardiomyocytes and neurons .

HY-P1076A

CALP2 TFA	Calmodulin	Inflammation/Immunology
CALP2 TFA is a calmodulin (CaM) antagonist (K_d of 7.9 µM) with high affinity for binding to the CaM EF-hand/Ca ²⁺-binding site. CALP2 TFA inhibits CaM-dependent phosphodiesterase activity and increases intracellular Ca ²⁺ concentrations. CALP2 TFA potently inhibits of adhesion and degranulation. CALP2 TFA is also a strong activator of alveolar macrophages .

HY-B1837A

β-Cyfluthrin beta-Cyfluthrin	Environmental Pollutants Calcium Channel SOD	Neurological Disease
β-Cyfluthrin (beta-Cyfluthrin) is a type II synthetic pyrethroid and also an active ingredient of many insecticide products used for pestsin agriculture. β-Cyfluthrin is a neurotoxicant and affects calcium concentration in nervous tissue by inhibiting Ca ²⁺ ATPase involved in calcium transport .

HY-113970A

Nebracetam hydrochloride WEB 1881 FU hydrochloride	mAChR Calcium Channel	Neurological Disease
Nebracetam (WEB 1881 FU) hydrochloride is an orally active M₁ muscarinic receptor agonist. Nebracetam hydrochloride can induce an increase in intracellular *Ca ²⁺* concentration, with an EC₅₀ value of 1.59 mM. Nebracetam hydrochloride exhibits neuroprotective activity and the ability to improve cognitive impairment. Nebracetam hydrochloride can be used in the research of neurological diseases such as Alzheimer's disease .

HY-A0236A

Aprindine hydrochloride	Sodium Channel Potassium Channel Calcium Channel Calmodulin	Cardiovascular Disease
Aprindine hydrochloride is an Ib-class anti-arrhythmic agent. Aprindine hydrochloride mainly exerts its effect by blocking sodium channels (I_Na), thereby reducing the excitability and conduction velocity of cardiac muscle cells. Aprindine hydrochloride significantly inhibits delayed potassium currents, which helps to prolong the atrial effective refractory period (AERP) and inhibit the occurrence of atrial fibrillation. Aprindine hydrochloride can also regulate intracellular calcium ion concentration by inhibiting Na ⁺/Ca ²⁺ exchange current (INCX), thereby further stabilizing cardiac electrical activity. Aprindine hydrochloride can be used for the study of atrial fibrillation (AF) and ventricular arrhythmias .

HY-D1700

Mag-indo-1/AM	Fluorescent Dye	Others
Mag-indo-1/AM is a cell-permeable fluorescent indicator for Mg ²⁺ and also for Ca ²⁺ (Ex=340-390 nm, Em=410-490 nm). Mag-indo-1/AM can be used to determine intracellular Mg ²⁺ and Ca ²⁺ concentrations .

HY-126789A

DM-Nitrophen tertasodium	Biochemical Assay Reagents	Metabolic Disease
DM-Nitrophen tertasodium is a photolabile caged calcium compound that acts as a calcium releaser. DM-Nitrophen tertasodium binds *Ca ²⁺* with high affinity and Mg ²⁺ with considerable affinity before photolysis. DM-Nitrophen tertasodium releases Ca ²⁺ into the cytosol upon ultraviolet light irradiation. DM-Nitrophen tertasodium induces calcium concentration pulses, triggers cytosolic calcium transients, promotes calcium-dependent exocytosis. DM-Nitrophen tertasodium can be used for the research of calcium-dependent cellular processes .

HY-DY1055

TSQ (solution)	Fluorescent Dye	Others
TSQ (solution) is a cytosolic zinc ion fluorescence probe that is membrane permeable and can be used for intracellular imaging of zinc proteins (λ_max ~470 nm). TSQ can combine with Zn ²⁺ in the presence of Ca ²⁺ and Mg ²⁺ to produce blue fluorescence (Ex/Em = 334/495 nm) . Solvent and concentration: DMSO: 10 mM

HY-14229R

TGR5 Receptor Agonist (Standard) CCDC (Standard)	G protein-coupled Bile Acid Receptor 1 Calcium Channel Reference Standards	Metabolic Disease
TGR5 Receptor Agonist (Standard) is the analytical standard of TGR5 Receptor Agonist. This product is intended for research and analytical applications. TGR5 Receptor Agonist (CCDC), a potent Takeda G protein-coupled receptor 5 (TGR5; GPCR19) agonist, shows improved potency in the U2-OS cells and melanophore cells with pEC50s of 6.8 and 7.5, respectively. TGR5 Receptor Agonist can induce peripheral and central hypersensitivity to bladder distension in mice, and increase intracellular Ca2+ concentration. TGR5 Receptor Agonist can also reduces food intake and improves insulin responsiveness, in diet-induced obese mice. TGR5 Receptor Agonist can be used to research diabetes, bladder hypersensitivity and anti-obesity .

HY-D2952

BOCA-1-BG	Fluorescent Dye	Others
BOCA-1-BG is a BODIPY-labeled SNAP tag fluorescence probe. BOCA-1-BG can be used to detect Ca ²⁺ concentration and serves as a highly sensitive Ca ²⁺ fluorescent indicator .

HY-103545

GIP (1-39) Gastric inhibitory peptide (1-39) (porcine)	Insulin Receptor	Metabolic Disease
GIP (1-39) (Gastric inhibitory peptide (1-39) (porcine)) is an insulinotropic peptide that stimulats insulin secretion from rat pancreatic islets. GIP (1-39) at 100 nM was able to significantly increase intracellular Ca ²⁺ concentration ([Ca ²⁺]_i), and capable of enhancing exocytosis .

HY-141613A

Dioleyl phosphatidylserine	PKC	Others
Dioleyl phosphatidylserine is a phospholipid that can be used to form the cochlea. Dioleyl phosphatidylserine (100 μM) can activate PKC-γ under Ca ²⁺ concentrations < 0.5 μM .

HY-B1837AR

β-Cyfluthrin (Standard) beta-Cyfluthrin (Standard)	Reference Standards Calcium Channel SOD	Neurological Disease
β-Cyfluthrin (Standard) is the analytical standard of β-Cyfluthrin. This product is intended for research and analytical applications. β-Cyfluthrin (beta-Cyfluthrin) is a type II synthetic pyrethroid and also an active ingredient of many insecticide products used for pestsin agriculture. β-Cyfluthrin is a neurotoxicant and affects calcium concentration in nervous tissue by inhibiting Ca ²⁺ ATPase involved in calcium transport .

HY-N6687B

Calcimycin hemimagnesium A-23187 hemimagnesium; Antibiotic A-23187 hemimagnesium	Oxidative Phosphorylation Antibiotic Bacterial Fungal Apoptosis Autophagy	Infection Cancer
Calcimycin (A-23187) hemimagnesium is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin hemimagnesium induces Ca ²⁺-dependent cell death by increasing intracellular calcium concentration. Calcimycin hemimagnesium inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin hemimagnesium also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin hemimagnesium induces apoptosis and autophagy .

HY-P5319

MCaE12A	Calcium Channel	Others
MCaE12A is a high-affinity modulator of RyR2 and increases RyR2 sensitivity to cytoplasmic calcium concentrations promoting channel opening. MCaE12A acts as an important tool for RyR2 structure-to-function studies as well as for manipulating Ca2+ homeostasis and dynamic of cardiac cell .

Cat. No.	Product Name

HY-L166

Ion Channel Compound Library

1,679 compounds

Ion channel is a membrane-binding enzyme whose catalytic site is an ion conduction pore, which is opened and closed in response to specific environmental stimuli (voltage, ligand concentration, membrane tension, temperature, etc.). Ion channel provide pores for the passive diffusion of ions on the biofilm. Due to their high selectivity for ion, ion channel are generally classified as sodium (Na⁺ ), potassium (K⁺ ), calcium (Ca²⁺ ), chloride (Cl^- ), and non-specific cation channel. Ion channel is an important contributor to cell signal transduction and homeostasis. In addition to electrical signal transduction, ion channel also have many functions: regulating vascular smooth muscle contraction, maintaining normal cell volume, regulating glandular secretion, protein kinase activation, etc. Therefore, dysfunction of ion channel can lead to many diseases, and its mechanism research is particularly important.

MCE designs a unique collection of 1,679 small molecules related to ion channel, mainly targeting Na⁺ channel, K⁺ channel, Ca²⁺ channel, GABA receptor, iGluR, etc. It is an essential tool for research of cardiovascular diseases, Nervous system diseases and other diseases.

Cat. No.	Product Name	Type

HY-DY1028

Fluo-4 AM (solution)	Fluorescent Dyes
Fluo-4 AM (solution) is a cell-permeable Ca ²⁺ (calcium ion) indicator (Ex/Em = 485/526 nm) . Solvent and concentration: DMSO: 1 mM

HY-D0202

Arsenazo III

Fluorescent Dyes

Arsenazo III is an azo derivative of chromotropic acid, a metal chrome dye, a chelating agent, and a cation complexing agent. Arsenazo III forms stable 1:1 complexes with Ca ²⁺, Mg ²⁺, Sr ²⁺, Ba ²⁺, K ⁺, and Na ⁺, and its binding affinity for Ca ²⁺ depends on pH, alkali metal cation concentration, and buffer parameters. Arsenazo III serves as a colorimetric indicator for micromolar ionized Ca ²⁺ in cells .

HY-DY1020

Rhod-2 AM (solution)

Fluorescent Dyes

Rhod-2 (solution) is a high-affinity visible light excitation wavelength Ca ²⁺ fluorescent probe, Rhod-2, AM is an acetyl methyl ester derivative of Rhod-2, which has cell membrane permeability and can easily enter cells with simple culture. Once it enters the cell, it is sheared by its lactesterase to produce Rhod-2 without membrane permeability, which remains in the cell to perform the corresponding physiological functions. Maximum excitation/emission wavelength: 549/578 nm .
Solvent and concentration: DMSO: 1 mM

HY-D1702

Mag-Fura-2 tetrapotassium	Fluorescent Dyes
Mag-Fura-2 tetrapotassium is a cell-impermeant UV excitable rational fluorescent Mg ²⁺/Ca ²⁺ indicator (Ex=334-360 nm, Em=510 nm). Mag-Fura-2 tetrapotassium can be used for the determination of Mg ²⁺ and Ca ²⁺ concentrations .

HY-D1700

Mag-indo-1/AM	Fluorescent Dyes
Mag-indo-1/AM is a cell-permeable fluorescent indicator for Mg ²⁺ and also for Ca ²⁺ (Ex=340-390 nm, Em=410-490 nm). Mag-indo-1/AM can be used to determine intracellular Mg ²⁺ and Ca ²⁺ concentrations .

HY-DY1055

TSQ (solution)	Fluorescent Dyes
TSQ (solution) is a cytosolic zinc ion fluorescence probe that is membrane permeable and can be used for intracellular imaging of zinc proteins (λ_max ~470 nm). TSQ can combine with Zn ²⁺ in the presence of Ca ²⁺ and Mg ²⁺ to produce blue fluorescence (Ex/Em = 334/495 nm) . Solvent and concentration: DMSO: 10 mM

HY-D2952

BOCA-1-BG	Fluorescent Dyes
BOCA-1-BG is a BODIPY-labeled SNAP tag fluorescence probe. BOCA-1-BG can be used to detect Ca ²⁺ concentration and serves as a highly sensitive Ca ²⁺ fluorescent indicator .

HY-D0121B

INDO 1 pentasodium

Fluorescent Dyes

INDO 1 pentasodium is a cell-impermeant ratiometric, free calcium ion (Ca ²⁺) fluorescent indicator that can quantitatively monitor dynamic changes in intracellular free Ca ²⁺ concentrations. When unbound to Ca ²⁺ (free state), INDO 1 pentasodium exhibits a peak emission wavelength of 485 nm under UV excitation (350 nm). Upon binding to Ca ²⁺ (bound state), the emission peak shifts to 405 nm. INDO 1 pentasodium is highly photolabile and susceptible to photobleaching, and its emission spectrum may overlap with the autofluorescence of NADH .

HY-DY1095

Fluo-3AM (solution)

Fluo-3-pentaacetoxymethyl ester (solution)

Fluorescent Dyes

Fluo-3AM (solution) is a fluorecent Ca ²⁺ chelator, with high affinity for calcium. Fluo-3 AM can specifically identify intracellular calcium ions, with high sensitivity, low cytotoxicity, increased AM acetylmethyl ester can enter the cell well, after being sheared by the intracellular esterase stay in the cell to bind to calcium ions, produce strong fluorescence .
Solvent and concentration: DMSO: 5 mM

HY-DY1101

Fura-2 AM (solution) Fura-2 Acetoxymethyl ester (solution)	Fluorescent Dyes
Fura-2 AM (solution) (Fura-2 Acetoxymethyl ester (solution)) is a membrane permeable, intracellular, UV light-excitable and ratiometric fluorescent Ca ²⁺ (calcium ion) indicator. Fura-2 AM crosses cell membranes and is converted to Fura-2 (HY-D0110A) via cellular esterases. Fura-2 AM can be used to detect calcium in cells. Solvent and concentration: DMSO: 1 mM

Cat. No.	Product Name	Type

HY-W250149

Chlorophosphonazo III

Biochemical Assay Reagents

Chlorophosphonazo III is a cell membrane-permeable contrast agent and spectrophotometric reagent. Chlorophosphonazo III forms stable 1:1 complexes with intracellular calcium, magnesium, uranium, titanium, zirconium, thorium, scandium, equivalent actinides and protactinium. Chlorophosphonazo III generates photoacoustic signals correlated with Ca ²⁺ concentrations, which is applicable for imaging 3D tumor cell cultures and tumor spheroids. Chlorophosphonazo III exhibits no cytotoxicity, can be used for spectrophotometric detection of target ions, and the absorbance of its complexes remains stable for up to one week within the pH range of 2.2 to 7.0 .

HY-W110910

Eriochrome black T, Indicator

Biochemical Assay Reagents

Eriochrome black T, Indicator is a complexing agent for metal ions (e.g., Ca ²⁺, Mg ²⁺) and is used as an indicator in complexometric titrations. Eriochrome black T, Indicator forms colored complexes with metal ions through covalent coordination bonds, and indicates the endpoint of the titration by color change. Eriochrome black T, Indicator can be used as an anionic azo dye in photocatalytic degradation studies to evaluate the performance of photocatalysts. The reaction solution of Eriochrome black T, Indicator combined with Mg ²⁺ is initially purple. During loop-mediated isothermal amplification (LAMP), the color changes from purple to sky blue due to the consumption of Mg ²⁺ by the formation of magnesium pyrophosphate, indicating a positive reaction. The optimal concentration of Eriochrome black T, Indicator in LAMP is 60 μM, and the detection limit for Mycobacterium tuberculosis is 1 pg DNA/reaction .

Cat. No.	Product Name	Target	Research Area

HY-P11292

Caloxin 1b3	Calcium Channel	Cardiovascular Disease
Caloxin 1b3, a peptide, is a selective plasma *membrane Ca ²⁺* pump 1 (PMCA1)** inhibitor. Caloxin 1b3 significantly inhibits PMCA1 Ca ²⁺–Mg ²⁺-ATPase in the rabbit duodenal mucosa than the PMCA4 in the human erythrocyte ghosts. Caloxin 1b3 also increases cytosolic Ca ²⁺ concentration in endothelial cells. Caloxin 1b3 can be used for cardiovascular disorders research .

HY-P5142

ω-Hexatoxin-Hv1a ω-ACTX-Hv1; ω-Atracotoxin-HV1	Insecticide Calcium Channel Apoptosis Necroptosis	Cardiovascular Disease Neurological Disease Inflammation/Immunology
ω-Hexatoxin-Hv1a (ω-ACTX-Hv1; ω-Atracotoxin-HV1) is an orally active insecticidal neurotoxin containing an inhibitor cystine knot motif and a selective calcium channel inhibitor. ω-Hexatoxin-Hv1a blocks L-type voltage-dependent Ca ²⁺ channels and reduces intracellular calcium ion concentration, thereby decreasing apoptosis, necroptosis and oxidative stress, and promoting cell recovery and energy level elevation. ω-Hexatoxin-Hv1a causes larval paralysis and death by impairing neurotransmission in the central nervous system of insects. It shows high injectable toxicity against insects of multiple orders, but exhibits weak oral toxicity. ω-Hexatoxin-Hv1a is widely applicable to studies related to ischemia-reperfusion injury, atopic dermatitis, and ischemic injury of cardiomyocytes and neurons .

HY-P1076A

CALP2 TFA	Calmodulin	Inflammation/Immunology
CALP2 TFA is a calmodulin (CaM) antagonist (K_d of 7.9 µM) with high affinity for binding to the CaM EF-hand/Ca ²⁺-binding site. CALP2 TFA inhibits CaM-dependent phosphodiesterase activity and increases intracellular Ca ²⁺ concentrations. CALP2 TFA potently inhibits of adhesion and degranulation. CALP2 TFA is also a strong activator of alveolar macrophages .

HY-103545

GIP (1-39) Gastric inhibitory peptide (1-39) (porcine)	Insulin Receptor	Metabolic Disease
GIP (1-39) (Gastric inhibitory peptide (1-39) (porcine)) is an insulinotropic peptide that stimulats insulin secretion from rat pancreatic islets. GIP (1-39) at 100 nM was able to significantly increase intracellular Ca ²⁺ concentration ([Ca ²⁺]_i), and capable of enhancing exocytosis .

HY-P5319

MCaE12A	Calcium Channel	Others
MCaE12A is a high-affinity modulator of RyR2 and increases RyR2 sensitivity to cytoplasmic calcium concentrations promoting channel opening. MCaE12A acts as an important tool for RyR2 structure-to-function studies as well as for manipulating Ca2+ homeostasis and dynamic of cardiac cell .

HY-P10328

Vasoactive intestinal contractor	DNA/RNA Synthesis	Metabolic Disease
Vasoactive intestinal contractor is a novel member of the endothelin family. Vasoactive intestinal contractor stimulates a rapid increase in the intracellular Ca ²⁺ concentration in fura-2-overexpressed Swiss 3T3 cells ^[1.

HY-P1076

CALP2	Calmodulin	Inflammation/Immunology
CALP2 is a calmodulin (CaM) antagonist ( (K_d of 7.9 µM)) with high affinity for binding to the CaM EF-hand/Ca ²⁺-binding site. CALP2 inhibits CaM-dependent phosphodiesterase activity and increases intracellular Ca ²⁺ concentrations. CALP2 potently inhibits of adhesion and degranulation. CALP2 is also a strong activator of alveolar macrophages .

HY-P5142A

ω-Hexatoxin-Hv1a TFA ω-ACTX-Hv1 TFA; ω-Atracotoxin-HV1 TFA	Insecticide Apoptosis Calcium Channel Necroptosis	Cardiovascular Disease Neurological Disease Inflammation/Immunology
ω-Hexatoxin-Hv1a (ω-ACTX-Hv1; ω-Atracotoxin-HV1) TFA is an orally active insecticidal neurotoxin containing an inhibitor cystine knot motif and a selective calcium channel inhibitor. ω-Hexatoxin-Hv1a TFA blocks L-type voltage-dependent Ca ²⁺ channels and reduces intracellular calcium ion concentration, thereby decreasing apoptosis, necroptosis and oxidative stress, and promoting cell recovery and energy level elevation. ω-Hexatoxin-Hv1a TFA causes larval paralysis and death by impairing neurotransmission in the central nervous system of insects. It shows high injectable toxicity against insects of multiple orders, but exhibits weak oral toxicity. ω-Hexatoxin-Hv1a TFA is widely applicable to studies related to ischemia-reperfusion injury, atopic dermatitis, and ischemic injury of cardiomyocytes and neurons .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6687

Calcimycin Maximum Cited Publications 24 Publications Verification A-23187; Antibiotic A-23187	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Polyether Antibiotics Source Classification	Oxidative Phosphorylation Bacterial Fungal Apoptosis Autophagy Antibiotic
Calcimycin (A-23187) is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin induces Ca ²⁺-dependent cell death by increasing intracellular calcium concentration. Calcimycin inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin induces apoptosis and autophagy .

HY-114252

Strophanthidin 1 Publications Verification	Cardiovascular Disease Classification of Application Fields Plants Brassicaceae Disease Research Fields Steroids Erysimum cheiranthoides Linn. Source Classification	Na+/K+ ATPase
Strophanthidin is a naturally available cardiac glycoside . Strophanthidin 0.1 and 1 nmol/L increases and 1~100 μmol/L inhibits the Na+/K+-ATPase activities, but Strophanthidin 10 and 100 nmol/L does not affect Na+/K+-ATPase activities in cardiac sarcolemmal . Strophanthidin increases both diastolic and systolic intracellular Ca ²⁺ concentration .

HY-103306

Ryanodine 5+ Cited Publications	Structural Classification other families Neurological Disease Classification of Application Fields Terpenoids Ryania speciosa Diterpenoids Plants Disease Research Fields Biological Pesticide Research Source Classification Agricultural Research	Environmental Pollutants Calcium Channel
Ryanodine is a cell permeant ryanodine receptor modulator. Ryanodine can either stimulate or inhibit Ryanodine-mediated Ca ²⁺ release depending on its concentrations. Poisonous diterpenoid found in Ryania speciosa.

HY-136409

N-Decanoyl-L-homoserine lactone C10-HSL	Microorganisms Source Classification	Bacterial Reactive Oxygen Species (ROS)
N-decanoyl-L-homoserine lactone (C10-HSL) is a N-acyl-homoserine lactone (AHL) N-decanoyl-L-homoserine lactone can inhibit primary root growth in Arabidopsis. N-decanoyl-L-homoserine lactone triggers a transient and immediate increase in the concentrations of cytosolic free Ca ²⁺ and reactive oxygen species (ROS), increases the activity of mitogen-activated protein kinase 6 (MPK6), and induces nitric oxide (NO) production in Arabidopsis roots .

HY-N2500

Deoxypodophyllotoxin	Infection Cardiovascular Disease other families Classification of Application Fields Centaurea ornata Lignans Phenylpropanoids Umbelliferae Plants Disease Research Fields Source Classification	Microtubule/Tubulin Apoptosis Autophagy
Deoxypodophyllotoxin (DPT), a derivative of podophyllotoxin, is a lignan with potent antimitotic, anti-inflammatory and antiviral properties isolated from Anthriscus sylvestris. Deoxypodophyllotoxin, targets the microtubule, has a major impact in oncology not only as anti-mitotics but also as potent inhibitors of angiogenesis . Deoxypodophyllotoxin induces cell autophagy and apoptosis . Deoxypodophyllotoxin evokes increase of intracellular Ca ²⁺ concentrations in DRG neurons .

HY-N0724

Mesaconitine 2 Publications Verification	Alkaloids Structural Classification Classification of Application Fields Ranunculaceae Other Diseases Aconitum carmichaeli Debx. Plants Isoquinoline Alkaloids Disease Research Fields Source Classification	TNF Receptor
Mesaconitine is a nitric oxide synthase activator. Mesaconitine drives extracellular Na ⁺ and Ca ²⁺ influx into endothelial cells, increases intracellular Na ⁺ and Ca ²⁺ concentrations, and triggers nitric oxide release. Mesaconitine is applicable for pain-related research .

HY-N7117

1,4-Cineole	Structural Classification Other Monoterpenes Classification of Application Fields Terpenoids Ericaceae Plants Rhododendron anthopogonoides Maxim. Inflammation/Immunology Disease Research Fields Cancer	Environmental Pollutants TRP Channel
1,4-Cineole is an oxygenated monoterpene found in eucalyptus oil. 1,4-Cineole is a hTRPM8 and hTRPA1 agonist. 1,4-Cineole can increase intracellular Ca ²⁺ concentration. 1,4-Cineole exhibits anti-anxiety and anti-depression effects. 1,4-Cineole can be used for the research of neurological disease, such as depression .

HY-N0642

α-L-Rhamnose monohydrate	Structural Classification other families Classification of Application Fields Metabolic Disease Plants Disease Research Fields Saccharides Monosaccharides Source Classification Cancer	Drug Derivative Calcium Channel
α-L-Rhamnose monohydrate is a neutral sugar present in plants, animals, viruses and bacteria. α-L-Rhamnose monohydrate is a ligand for α-L-rhamnose-recognizing lectin sites, trigger intracellular signaling pathways. α-L-Rhamnose monohydrate induces rhaE and rhaA expression as a specific carbon source in Aspergillus nidulans, while glucose inhibits its cellular uptake. α-L-Rhamnose monohydrate induces rapid and transient increases in intracellular free *Ca ²⁺* concentration in normal human dermal fibroblasts .

HY-N5123

α-L-Rhamnose	Structural Classification Microorganisms Classification of Application Fields Other Diseases Disease Research Fields Saccharides Monosaccharides Source Classification	Endogenous Metabolite
α-L-Rhamnose is a neutral sugar present in plants, animals, viruses and bacteria. α-L-Rhamnose is a ligand for α-L-rhamnose-recognizing lectin sites, trigger intracellular signaling pathways. α-L-Rhamnose induces rhaE and rhaA expression as a specific carbon source in Aspergillus nidulans, while glucose inhibits its cellular uptake. α-L-Rhamnose induces rapid and transient increases in intracellular free *Ca ²⁺* concentration in normal human dermal fibroblasts .

HY-114252R

Strophanthidin (Standard)	Structural Classification Plants Brassicaceae Steroids Erysimum cheiranthoides Linn. Source Classification	Reference Standards Na+/K+ ATPase
Strophanthidin (Standard) is the analytical standard of Strophanthidin. This product is intended for research and analytical applications. Strophanthidin is a naturally available cardiac glycoside . Strophanthidin 0.1 and 1 nmol/L increases and 1~100 μmol/L inhibits the Na+/K+-ATPase activities, but Strophanthidin 10 and 100 nmol/L does not affect Na+/K+-ATPase activities in cardiac sarcolemmal . Strophanthidin increases both diastolic and systolic intracellular Ca2+ concentration .

HY-N11887

Linocinnamarin	Natural Products Rosaceae Plants Source Classification Fragaria × ananassa Duch.	Reactive Oxygen Species (ROS)
Linocinnamarin is a nature product that could be isolated from Fragaria ananassa Duch. Linocinnamarin has anti-inflammatory activity. Linocinnamarin inhibits antigen-stimulated elevation of intracellular free Ca ²⁺ concentration and reactive oxygen species (ROS) .

HY-N6687R

Calcimycin (Standard) A-23187 (Standard); Antibiotic A-23187 (Standard)	Structural Classification Microorganisms Antibiotics Antibacterial Disease Research Polyether Antibiotics Source Classification	Oxidative Phosphorylation Reference Standards Bacterial Fungal Apoptosis Autophagy Antibiotic
Calcimycin (Standard) is the analytical standard of Calcimycin. This product is used for research and analytical applications. Calcimycin is an antibiotic and a unique divalent cation ionophore, such as calcium ions and magnesium ions. Calcimycin induces Ca ²⁺ -dependent cell death by increasing the intracellular calcium concentration. Calcimycin inhibits the growth of Gram-positive bacteria and some fungi, and also inhibits the activity of ATPase and uncouples the oxidative phosphorylation (OXPHOS) of mammalian cells, inducing apoptosis and autophagy.

HY-N6687A

Calcimycin hemicalcium salt A-23187 hemiCalcium salt; Antibiotic A-23187 hemiCalcium salt	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Polyether Antibiotics Source Classification	Oxidative Phosphorylation Bacterial Fungal Apoptosis Autophagy Antibiotic
Calcimycin (A-23187) hemicalcium salt is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin hemicalcium salt induces Ca ²⁺-dependent cell death by increasing intracellular calcium concentration. Calcimycin hemicalcium salt inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin hemicalcium salt also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin hemicalcium salt induces apoptosis and autophagy .

HY-N7117R

1,4-Cineole (Standard)	Structural Classification Other Monoterpenes Terpenoids Ericaceae Plants Rhododendron anthopogonoides Maxim.	Reference Standards TRP Channel
1,4-Cineole (Standard) is the analytical standard of 1,4-Cineole (HY-N7117). 1,4-Cineole is an oxygenated monoterpene found in eucalyptus oil. 1,4-Cineole is a hTRPM8 and hTRPA1 agonist. 1,4-Cineole can increase intracellular Ca ²⁺ concentration. 1,4-Cineole exhibits anti-anxiety and anti-depression effects. 1,4-Cineole can be used for the research of neurological disease, such as depression .

HY-N18279

Bulbocapnine	Structural Classification Alkaloids Corydalis yanhusuo W. T. Wang Quinoline Alkaloids Plants Papaveraceae Source Classification	Dopamine Receptor Adrenergic Receptor
Bulbocapnine is an aporphine isoquinoline alkaloid that exerts antagonistic effects on dopamine Receptor) and α-adrenergic receptors, as well as anti-peroxidative effects. The K_i value of bulbocapnine for tyrosine hydroxylase (TH) is 0.20 mM. Bulbocapnine reduces intracellular dopamine content, inhibits TH activity, and decreases *Ca ²⁺* concentration. Bulbocapnine antagonizes the dose-dependent inhibitory effect of dopamine on the heart rate acceleration induced by stimulating the postganglionic fibers of the right cardiac accelerator nerve .

Cat. No.	Product Name	Chemical Structure

HY-B0561S4

Spironolactone-d6-1

Spironolactone-d₆-1 is the deuterium labeled Spironolactone (HY-B0561). Spironolactone is an aldosterone antagonist that acts on the aldosterone mineralocorticoid receptor (IC₅₀=24 nM) and androgen receptor (IC₅₀=77 nM), promotes podocyte autophagy and regulates pain. Spironolactone improves hypertension-related vascular hypertrophy and remodeling by reducing angiotensin II (Ang II)-induced inflammation, reduces aldosterone-induced vascular and soft tissue calcification through PIT1-dependent signaling, and alleviates vascular dysfunction in type II diabetic mice by reducing oxidative stress and restoring NO/GC signaling; at low concentrations, it and its metabolites can interfere with aldosterone biosynthesis in the adrenal cortex and inhibit voltage-dependent Ca ²⁺ channels to exert antihypertensive effects .

HY-B0596S

Taltirelin-13C,d3
Taltirelin- ¹³C,d₃ (TA-0910- ¹³C,d₃) is ¹³C and deuterated labeled Taltirelin (HY-B0596). Taltirelin (TA0910) is a superagonist at thyrotropin-releasing hormone receptor (TRH-R) with an IC₅₀ of 910 nM and EC₅₀ of 36 nM for stimulating an increase in cytosolic Ca ²⁺ concentration (Ca ²⁺ release).

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