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Lactate+Dehydrogenase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Lactate Dehydrogenase (69) 5-HT Receptor (1) AIM2 (1) Aminotransferases (Transaminases) (1) Apoptosis (15) Bacterial (5) Biochemical Assay Reagents (4) Calcium Channel (3) Caspase (2) CD38 (1) Cholinesterase (ChE) (1) Cytochrome P450 (1) DNA/RNA Synthesis (1) Drug Derivative (3) Drug Metabolite (1) Endogenous Metabolite (6) Endonuclease (1) Environmental Pollutants (2) Fluorescent Dye (1) Formyl Peptide Receptor (FPR) (1) Fungal (1) GLUT (1) Glutathione S-transferase (1) IMPDH (1) Interleukin Related (2) Isotope-Labeled Compounds (1) Keap1-Nrf2 (1) Na+/H+ Exchanger (NHE) (1) Neurokinin Receptor (1) NO Synthase (2) NOD-like Receptor (NLR) (2) Oxidative Phosphorylation (1) Parasite (5) PDI (1) Potassium Channel (2) Prostaglandin Receptor (1) Pyroptosis (1) Reactive Oxygen Species (ROS) (10) Reference Standards (8) Sirtuin (1) Small Interfering RNA (siRNA) (2) SOD (1)
By Research Areas:	Cancer (45) Cardiovascular Disease (10) Endocrinology (3) Infection (11) Inflammation/Immunology (12) Metabolic Disease (21) Neurological Disease (6)
Oligonucleotides:	siRNA drugs (2) siRNAs (2)

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended: Lactate Dehydrogenase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W013032A

Oxamic acid sodium Maximum Cited Publications 58 Publications Verification Sodium oxamate	Lactate Dehydrogenase Apoptosis	Cancer
Oxamic acid (oxamate) sodium salt is a *lactate dehydrogenase-A* (LDH-A) inhibitor. Oxamic acid sodium salt shows anti-tumor activity, and anti-proliferative activity against cancer cells, and can induce apoptosis .

HY-100681

GSK2837808A 40+ Cited Publications	Lactate Dehydrogenase	Cancer
GSK2837808A is a potent and selective lactate dehydrogenase A (LDHA) inhibitor with IC₅₀s of 2.6 and 43 nM for hLDHA and hLDHB, respectively.

HY-100742A

(R)-GNE-140 15+ Cited Publications	Lactate Dehydrogenase	Cancer
(R)-GNE-140 is a potent lactate dehydrogenase A (LDHA) inhibitor, with IC₅₀s of 3 nM and 5 nM for LDHA and LDHB, respectively; (R)-GNE-140 is 18-fold more potent than S enantiomer.

HY-16214

FX-11 25+ Cited Publications LDHA Inhibitor FX11	Lactate Dehydrogenase Apoptosis Reactive Oxygen Species (ROS)	Cancer
FX-11 is a potent, selective, reversible and competitive lactate dehydrogenase A (LDHA) inhibitor, with a K_i of 8 μM. FX-11 reduces ATP levels and induces oxidative stress, ROS production and cell death. FX-11 shows antitumor activity in lymphoma and pancreatic cancer xenografts .

HY-W013032

Oxamic acid Maximum Cited Publications 58 Publications Verification Oxamidic acid	Lactate Dehydrogenase Apoptosis	Cancer
Oxamic acid is a *lactate dehydrogenase-A* (LDH-A) inhibitor. Oxamic acid shows anti-tumor activity, and anti-proliferative activity against cancer cells, and can induce apoptosis .

HY-W040118

Galloflavin 10+ Cited Publications	Lactate Dehydrogenase	Cancer
Galloflavin is a potent lactate dehydrogenase (LDH) inhibitor. The calculated K_is for pyruvate are 5.46 μM (LDH-A) and 15.06 μM (LDH-B). Galloflavin hinders the proliferation of cancer cells by blocking glycolysis and ATP production .

HY-N10574

Queuine 1 Publications Verification	Bacterial	Metabolic Disease Cancer
Queuine is a selective substrate for tRNA guanine transglycosylase (TGT) and can be incorporated into eukaryotic tRNA. Queuine promotes tRNA modification, affecting mitochondrial function and Warburg metabolic phenotype. If Queuine is deficient, aerobic glycolysis can be enhanced, oxidative phosphorylation can be inhibited, and Warburg metabolism can be promoted, accompanied by increased ammonia and lactate production and increased lactate dehydrogenase activity. Queuine can be used for autoimmune diseases (such as experimental models of multiple sclerosis) and cancer metabolic regulation, and its deficiency is associated with low tRNA modification in tumor cells .

HY-W040073

Nifurtimox 1 Publications Verification	Parasite Lactate Dehydrogenase	Infection Cancer
Nifurtimox, an antiprotozoal agent, which is generally used for the treatment of infections with Trypanosoma cruzi, has been used in the therapy of neuroblastoma. Nifurtimox affects enzyme activity of *lactate dehydrogenase* (LDH).

HY-P2807I

*L-Lactate Dehydrogenase, rabbit muscle*	Lactate Dehydrogenase	Others
L-Lactate Dehydrogenase, rabbit muscle is a biological material or organic compound that can be used in life science research .

HY-P2807F

Lactate Dehydrogenase (LDH), Bovine Heart LAD, LD, L-LDH, (S)-Lactate: NAD+ oxidoreductase	Lactate Dehydrogenase	Cardiovascular Disease
Lactate Dehydrogenase (LDH), Bovine Heart (LAD) is an oxidoreductase that catalyzes the reversible conversion between lactate and pyruvate. Lactate Dehydrogenase (LDH), Bovine Heart is mainly used in life science research, tissue damage diagnosis, and as an enzyme marker .

HY-111108

LDH-IN-1 2 Publications Verification	Lactate Dehydrogenase	Cancer
LDH-IN-1 is a novel pyrazole-based inhibitor of human lactate dehydrogenase (LDH) with IC₅₀s of 32 and 27 nM for LDHA and LDHB, respectively.

HY-P2807

*L-Lactate dehydrogenase, E.coli* LAD	Endogenous Metabolite	Inflammation/Immunology Cancer
L-Lactate dehydrogenase, E.coli is a redox enzyme. L-Lactate dehydrogenase, E.coli catalyzes the reduction of pyruvate to L-lactate by NADH in vivo with absolute enantiospecificity .

HY-100742

GNE-140 racemate 5+ Cited Publications	Lactate Dehydrogenase	Cancer
GNE-140 racemate is a racemate mixture of (R)-GNE-140 and (S)-GNE-140. GNE-140 racemate is a potent lactate dehydrogenase A (LDHA) inhibitor .

HY-132606A

Nedosiran sodium DCR-PHXC sodium	Small Interfering RNA (siRNA) Lactate Dehydrogenase	Metabolic Disease
Nedosiran (DCR-PHXC) sodium is an RNA interference (RNAi) targeting lactate dehydrogenase (LDH). Nedosiran sodium represents an impactful potential therapeutic for primary hyperoxaluria (PH) with end-stage renal disease (ESRD). Nedosiran sodium is a GalNAc-dsRNA conjugate .

HY-P2897

*D-Lactate dehydrogenase, Microorganism* 1 Publications Verification D-LDH	Lactate Dehydrogenase	Others
D-Lactate dehydrogenase, Microorganism (D-LDH) is an oxidoreductase that uses NAD ⁺ or NADP ⁺ as an acceptor and acts on the donor CH-OH group, and can catalyze the oxidation of D-lactate to pyruvate. D-Lactate dehydrogenase widely exists in bacteria and fungi, and is often used in biochemical research .

HY-147216

AXKO-0046 5 Publications Verification	Lactate Dehydrogenase	Cancer
AXKO-0046, indole derivative, is an uncompetitive Lactate dehydrogenase B (LDHB) selective inhibitor.AXKO-0046 has LDHB inhibitory activity with an EC₅₀ value of 42 nM.AXKO-0046 can be used for the research of cancer metabolism .

HY-18968

AZ-33 1 Publications Verification LDHA-IN-4	Lactate Dehydrogenase	Cancer
AZ-33 (LDHA-IN-4) (compound 33) is a selective lactate dehydrogenase A (LDHA) inhibitor with an IC₅₀ of 0.5 μM and a K_d of 0.093 μM .

HY-P2807A

Lactate Dehydrogenase (LDH), Porcine Heart LDH, Lactic Dehydrogenase	Biochemical Assay Reagents	Cardiovascular Disease
Lactate Dehydrogenase (LDH), Porcine Heart, is an isoenzyme of lactate dehydrogenase derived from porcine heart. Lactate Dehydrogenase (LDH), Porcine Heart, is primarily used in life science research, tissue damage diagnosis, and as an enzyme marker .

HY-N7393

Isomalt Palatinitol	Environmental Pollutants Lactate Dehydrogenase	Metabolic Disease
Isomalt (Palatinitol), a well-tolerated, non-toxic polyol and a protein-stabilizing excipient, stabilizes lactate dehydrogenase (LDH) moderately during freeze-drying, and performs better during storage. Isomalt is traditionally used as a sweetening agent in the food industry and as a tabletting excipient for pharmaceutical purposes .

HY-152670

JC2-11 1 Publications Verification	NOD-like Receptor (NLR) AIM2	Inflammation/Immunology
JC2-11 is an inhibitor of inflammatory corpuscles. JC2-11 inhibits domain-containing protein NLRC 4, absent in melanoma 2 (AIM 2) and non-canonical (NC) inflammatory corpuscles. JC2-11 reduces the secretion of caspase-1 (p20), the cleavage of gasdermin D (GSDMD), and the releases of IL-1β and lactate dehydrogenases (LDH) in inflammatory bodies. JC2-11 inhibits the activation of inflammatory bodies by destroying the production of reactive oxygen species and the activity of caspase-1 .

HY-124113

4'-Bromo-resveratrol 4′‐BR	Sirtuin Apoptosis Caspase Lactate Dehydrogenase GLUT	Metabolic Disease Inflammation/Immunology Cancer
4'-Bromo-resveratrol (4′‐BR) is a dual SIRT1/SIRT3 inhibitor with an IC₅₀ of 0.2 mM for both targets. 4'-Bromo-resveratrol induces caspase-dependent apoptosis, induces G0/G1 cell cycle arrest, and inhiibits proliferation. 4'-Bromo-resveratrol reduces lactate production, glucose uptake, and NAD ⁺/NADH ratio, and downregulates lactate dehydrogenase A and glucose transporter 1 (GLUT1). 4'-Bromo-resveratrol can be used for the research of melanoma .

HY-113098

2-Oxovaleric acid	Lactate Dehydrogenase Drug Derivative	Metabolic Disease
2-Oxovaleric acid is an analog of Pyruvate and a substrate inhibitor of *Lactate dehydrogenase, exhibiting substrate inhibitory activity against lactate dehydrogenase* from Phycomyces blakesleeanus .

HY-B0854

Mancozeb	Environmental Pollutants Lactate Dehydrogenase Apoptosis Fungal Cytochrome P450 Keap1-Nrf2	Infection Metabolic Disease Cancer
Mancozeb is a widely used fungicide that is effective against fungal diseases in most cereals, vegetables, fruits and ornamental plants. In addition, Mancozeb can cause liver damage in mice by activating the Keap1/Nrf2 signaling pathway. Mancozeb upregulates *lactate dehydrogenase* and cytochrome c to alter cell metabolism and induce cell death. Mancozeb has reproductive toxicity and can induce apoptosis in ovarian cells .

HY-124309

NHI-2	Lactate Dehydrogenase Apoptosis	Cancer
NHI-2 is a lactate dehydrogenase A (LDHA) inhibitor with an IC₅₀ of 14.7 µM. NHI-2 shows selective for LDHA over LDHB (IC₅₀ = 55.8 µM). NHI-2 is an efficient anti-glycolytic agent. NHI-2 enhances apoptosis, induces cell cycle arrest at S and G2 phases. NHI-2 has a broad spectrum anti-proliferative activity in cancer cells. NHI-2 affects extracellular acidification rate and ATP production. NHI-2 suppresses tumor growth in murine B78 melanoma tumor model .

HY-100742B

(S)-GNE-140	Lactate Dehydrogenase	Cancer
(S)-GNE-140 is the less active enantiomer of GNE-140 which can inhibit Lactate dehydrogenase A (LDHA).

HY-131485

3-Acetylpyridine adenine dinucleotide, 90% 3-APAD, 90%; 3-Acetylpyridine NAD, 90%	Lactate Dehydrogenase	Metabolic Disease
3-Acetylpyridine adenine dinucleotide, 90% is an analog of nicotinamide adenine dinucleotide (NAD). 33-Acetylpyridine adenine dinucleotide, 90% collaboratively inhibits Lactate Dehydrogenase (LDH) with bisulfite .

HY-139319

LDHA-IN-3 2 Publications Verification	Lactate Dehydrogenase	Cancer
LDHA-IN-3 (compound 2), as a selenobenzene compound, is a potent, noncompetitive lactate dehydrogenase (LDHA) inhibitor (IC₅₀=145.2 nM). LDHA-IN-3 can be used for the research of cancer .

HY-D0808

Meldola blue	Fluorescent Dye
Meldola blue is a biosensor for measuring lactate in serum based on screen-printed carbon electrodes modified with Meldola's Blue-Reinecke salt (MBRS-SPCE) coated with lactate dehydrogenase NAD+-dependent enzyme (from pig heart) and NAD+.

HY-147216A

AXKO-0046 dihydrochloride 5 Publications Verification	Lactate Dehydrogenase	Metabolic Disease Inflammation/Immunology Cancer
AXKO-0046 dihydrochloride, indole derivative, is an uncompetitive Lactate dehydrogenase B (LDHB) selective inhibitor. AXKO-0046 dihydrochloride has LDHB inhibitory activity with an EC₅₀ value of 42 nM. AXKO-0046 dihydrochloride can be used for the research of cancer metabolism .

HY-176798

NCI-006	Lactate Dehydrogenase Reactive Oxygen Species (ROS) Apoptosis	Cancer
NCI-006 is an orally active *lactate dehydrogenase* (LDH) inhibitor (LDHA IC₅₀ = 0.06 μM; LDHB IC₅₀ = 0.03 μM). NCI-006 inhibits intratumoral LDH activity, lactate production, and tumor growth in a mouse pancreatic cancer model. NCI-006 inhibits glycolysis and induces apoptosis in vitro. NCI-006 enhances the radiosensitivity of glycolytic tumor cell lines while sparing non-glycolytic/normal cells (1522, skin fibroblasts) in combination with ionizing radiation (IR). NCI-006 exhibits synergistic antitumor effects in combination with IACS-010759 (HY-112037) against colorectal and gastric cancers. NCI-006 targets glycolysis by inhibiting lactate dehydrogenase impairs tumor growth in an Ewing sarcoma model .

HY-153129

EP2 receptor antagonist-2	Prostaglandin Receptor	Endocrinology
EP2 receptor antagonist-2 (CID891729) is an antagonist of EP2 receptor. EP2 receptor antagonist-2 inhibits the EP2 receptor activation induced by PGE2. EP2 receptor antagonist-2 also suppresses lactate dehydrogenase (LDH) release induced by N-methyl-D-aspartate (NMDA) .

HY-34154

4-(Dimethylamino)phenol	Lactate Dehydrogenase	Others
4-(Dimethylamino)phenol is a potent cyanide antidote. 4-(Dimethylamino)phenol increases the extracellular lactate dehydrogenase (LDH) without markedly affecting gluconeogenesis. 4-(Dimethylamino)phenol cannot decreases the ATP content until the membrane becomes permeable to LDH. 4-(Dimethylamino)phenol’s toxicity is related to its reaction with glutathione and formation of covalent complexes, leading to impaired cellular function .

HY-W088011B

Sodium glycolate, 98% Sodium hydroxyacetate, 98%	Lactate Dehydrogenase Aminotransferases (Transaminases)	Endocrinology
Sodium glycolate, 98% (Sodium hydroxyacetate, 98%) is an orally active, versatile organic salt . Sodium glycolate, 98% acts as an enzyme activity regulator that increases the activities of glycolate oxidase (GAO) and lactate dehydrogenase (LDH), while reducing the activity of glycolate dehydrogenase (GAD). Sodium glycolate, 98% induces oxalate biosynthesis and causes hyperoxaluria in rats. Sodium glycolate, 98% reduces urinary calcium excretion in male albino rats. Sodium glycolate, 98% can be used in studies related to calcium oxalate urolithiasis and hyperoxaluria .

HY-N10574A

Queuine dihydrochloride 1 Publications Verification	Others	Metabolic Disease Cancer
Queuine dihydrochloride is a selective substrate for tRNA guanine transglycosylase (TGT) and can be incorporated into eukaryotic tRNA. Queuine dihydrochloride promotes tRNA modification, affecting mitochondrial function and Warburg metabolic phenotype. If Queuine dihydrochloride is deficient, aerobic glycolysis can be enhanced, oxidative phosphorylation can be inhibited, and Warburg metabolism can be promoted, accompanied by increased ammonia and lactate production and increased lactate dehydrogenase activity. Queuine dihydrochloride can be used for autoimmune diseases (such as experimental models of multiple sclerosis) and cancer metabolic regulation, and its deficiency is associated with low tRNA modification in tumor cells .

HY-132606

Nedosiran DCR-PHXC	Small Interfering RNA (siRNA) Lactate Dehydrogenase	Metabolic Disease
Nedosiran (DCR-PHXC) is an RNA interference (RNAi) targeting lactate dehydrogenase (LDH). Nedosiran represents an impactful potential therapeutic for primary hyperoxaluria (PH) with end-stage renal disease (ESRD). Nedosiran is a GalNAc-dsRNA conjugate .

HY-N2177

3-Dehydrotrametenolic acid	Lactate Dehydrogenase Apoptosis	Cancer
3-Dehydrotrametenolic acid, isolated from the sclerotium of Poria cocos, is a lactate dehydrogenase (LDH) inhibitor. 3-Dehydrotrametenolic acid promotes adipocyte differentiation in vitro and acts as an insulin sensitizer in vivo. 3-Dehydrotrametenolic acid induces apoptosis and has anticancer activity .

HY-171944

6-O-Oleoyltrehalose	Drug Derivative Lactate Dehydrogenase	Others
6-O-Oleoyltrehalose is a derivative of trehalose. 6-O-Oleoyltrehalose has biodegradable and low surface tension reduction ability. 6-O-Oleoyltrehalose preserves Lactate dehydrogenase (LDH) activity during freeze/thaw cycles. 6-O-Oleoyltrehalose can be used for stabilizer research .

HY-W016203

Phenylpyruvic acid sodium Sodium phenylpyruvate	Endogenous Metabolite PDI	Infection Metabolic Disease
Phenylpyruvic acid sodium is a endogenous metabolite that participates in the synthesis of 3-phenyllactic acid (PLA) by lactate dehydrogenase. Phenylpyruvic acid is a precursor of the antifungal compound phenyllactic acid. Phenylpyruvic acid can improve the antifungal activity of eight lactic acid bacterial strains through the addition into a dedined growth medium. Phenylpyruvic acid demonstrates improved inhibitory activity against fungal bread contaminants Aspergillus niger and Penicillium roqueforti. Phenylpyruvic acid affects enzyme activity of the pentose phosphate pathway involved in the oxidative phase in rat brain homogenates. Phenylpyruvic acid can reduce glucose-6-phosphate dehydrogenase activity .

HY-147342

β-Benzamide adenine dinucleotide	Drug Metabolite IMPDH	Cancer
β-Benzamide adenine dinucleotide is a biologically active metabolite of benzamide riboside. β-Benzamide adenine dinucleotide is a competitive inhibitor of human NAD kinase with a K_i value of 90 μM, and inhibits human IMPDH with IC₅₀ values of 0.787 μM and 0.884 μM for type I and type II, respectively. β-Benzamide adenine dinucleotide exhibits inhibitory activities against lactate dehydrogenase, glutamate dehydrogenase, and malate dehydrogenase. β-Benzamide adenine dinucleotide can be used for the study of chronic myelogenous leukemia .

HY-130502

5β,6β-Epoxycholestanol Cholesterol 5β,6β-epoxide; 5β,6β-Epoxycholesterol	Apoptosis	Inflammation/Immunology Cancer
5β,6β-epoxycholestanol (Cholesterol 5β,6β-epoxide; 5β,6β-Epoxycholesterol) is an oxysterol. 5β,6β-epoxycholestanol induces cytotoxicity in bronchial epithelial cells. 5β,6β-epoxycholestanol induces lactate dehydrogenase (LDH) release and apoptosis in lymphoma cells undergoing macrophage differentiation . 5β,6β-epoxycholestanol is applicable to research related to atherosclerosis .

HY-N2498

Glomeratose A	Lactate Dehydrogenase	Others
Glomeratose A is a *lactate dehydrogenase* inhibitor, isolated from Polygala tenuifolia .

HY-P2807K

*L-Lactate Dehydrogenase, bovine muscle*	Endogenous Metabolite	Metabolic Disease
L-Lactate Dehydrogenase, bovine muscle is an oxidoreductase. L-Lactate Dehydrogenase, bovine muscle catalyzes the reversible conversion of lactate to pyruvate with the reduction of NAD+ to NADH .

HY-P2807J

*L-Lactate Dehydrogenase* (L-LDH), pig muscle**	Lactate Dehydrogenase	Metabolic Disease
L-Lactate Dehydrogenase (L-LDH), pig muscle is an L-lactate dehydrogenase found in pig muscle, mainly present in anaerobic tissues (skeletal muscle, red blood cells). L-Lactate Dehydrogenase (L-LDH), pig muscle can interact with acidic liposomes at low pH, causing protein to adsorb onto the liposomes and inhibit enzyme activity. The IC₅₀ values for L-Lactate Dehydrogenase (L-LDH), pig muscle are 0.05 μM for cardiolipin and 1.3 μM for phosphatidylserine liposomes .

HY-113383

2-Hydroxyvaleric acid	Endogenous Metabolite Lactate Dehydrogenase Biochemical Assay Reagents	Metabolic Disease Endocrinology
2-Hydroxyvaleric acid is a medium chain α-hydroxy fatty acid. 2-Hydroxyvaleric acid is an activator in fat metabolism of palmitic acid-1-C ¹⁴. 2-hydroxyvaleric acid is also used as a staining agent for measuring tissue-specific *Lactate dehydrogenase* activity and elevated levels of 2-hydroxyvaleric acid induces lactic acidosis .

HY-155335

FPR2 agonist 3	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
FPR2 agonist 3 (compound CMC23) can limit the *lactate dehydrogenase* release in LPS (HY-D1056) -stimulated cultures and decrease the levels of pro-inflammatory IL-1β and IL-6. FPR2 agonist 3 decrease the level of phosphor-STAT3 via the STAT3/SOCS3 signaling pathway .

HY-P2807G

Lactate Dehydrogenase (LDH), Chicken Heart LAD, LD, L-LDH, (S)-Lactate, LDH	Lactate Dehydrogenase	Others
Lactate Dehydrogenase (LDH), Chicken Heart (LAD, LD, L-LDH, (S)-Lactate, LDH) is a biological material or organic compound that can be used in life science research .

HY-P10563

Noraramtide BHV-1100	CD38	Cancer
Noraramtide (BHV-1100) is an antibody recruitment molecule. Noraramtide can specifically bind to CD38 molecules to recruit natural killer (NK) cells. Noraramtide enhances the ability of NK cells to kill tumor cells through antibody-dependent cellular cytotoxicity (ADCC). This mechanism allows NK cells to more effectively recognize and eliminate tumor cells while avoiding mutual killing between NK cells. Noraramtide can be used for the study of autologous cancer immunity .

HY-139182

MAGL-IN-3	Endogenous Metabolite	Metabolic Disease
CAY10762 is an inhibitor of monoacylglycerol lipase (MAGL; IC₅₀=34.1 nM). It reduces hydrogen peroxide-induced lactate dehydrogenase (LDH) release from Neuro2a cells when used at a concentration of 1 μM. CAY10762 (10 mg/kg) increases levels of 2-arachidonoyl glycerol in mouse brain.

HY-151243

NCATS-SM1441	Lactate Dehydrogenase	Cancer
NCATS-SM1441 (compound 52) is a lactate dehydrogenase (LDH) inhibitor (IC₅₀=40 nM). By inhibiting the activity of LDH, NCATS-SM1441 is able to reduce the production of lactic acid in cancer cells, helping to slow or stop the proliferation of cancer cells. NCATS-SM1441 can be used to study cancer metabolism .

HY-131829

N6-(2-Aminoethyl)-NAD+ 6-AE-NAD+	Biochemical Assay Reagents	Others
N6-(2-Aminoethyl)-NAD+ (6-AE-NAD+) is a NAD+ derivative commonly used in affinity chromatography. N6-(2-Aminoethyl)-NAD+ can be covalently linked to a PQQ (pyrroloquinoline quinone) (HY-100196) monolayer on an electrode surface for immobilizing NAD+-dependent enzymes such as lactate dehydrogenase (LDH) .

Cat. No.	Product Name	Type

HY-131485

3-Acetylpyridine adenine dinucleotide, 90% 3-APAD, 90%; 3-Acetylpyridine NAD, 90%	Biochemical Assay Reagents
3-Acetylpyridine adenine dinucleotide, 90% is an analog of nicotinamide adenine dinucleotide (NAD). 33-Acetylpyridine adenine dinucleotide, 90% collaboratively inhibits Lactate Dehydrogenase (LDH) with bisulfite .

HY-W088011B

Sodium glycolate, 98%

Sodium hydroxyacetate, 98%

Biochemical Assay Reagents

Sodium glycolate, 98% (Sodium hydroxyacetate, 98%) is an orally active, versatile organic salt . Sodium glycolate, 98% acts as an enzyme activity regulator that increases the activities of glycolate oxidase (GAO) and lactate dehydrogenase (LDH), while reducing the activity of glycolate dehydrogenase (GAD). Sodium glycolate, 98% induces oxalate biosynthesis and causes hyperoxaluria in rats. Sodium glycolate, 98% reduces urinary calcium excretion in male albino rats. Sodium glycolate, 98% can be used in studies related to calcium oxalate urolithiasis and hyperoxaluria .

HY-130502

5β,6β-Epoxycholestanol

Cholesterol 5β,6β-epoxide; 5β,6β-Epoxycholesterol

Biochemical Assay Reagents

5β,6β-epoxycholestanol (Cholesterol 5β,6β-epoxide; 5β,6β-Epoxycholesterol) is an oxysterol. 5β,6β-epoxycholestanol induces cytotoxicity in bronchial epithelial cells. 5β,6β-epoxycholestanol induces lactate dehydrogenase (LDH) release and apoptosis in lymphoma cells undergoing macrophage differentiation . 5β,6β-epoxycholestanol is applicable to research related to atherosclerosis .

HY-131485A

3-Acetylpyridine adenine dinucleotide, 95% 3-APAD, 95%; 3-Acetylpyridine NAD, 95%	Biochemical Assay Reagents
3-Acetylpyridine adenine dinucleotide, 95% (3-APAD, 95%)is an analog of nicotinamide adenine dinucleotide (NAD). 33-Acetylpyridine adenine dinucleotide, 95% collaboratively inhibits Lactate Dehydrogenase (LDH) with bisulfite .

Cat. No.	Product Name	Target	Research Area

HY-P10563

Noraramtide BHV-1100	CD38	Cancer
Noraramtide (BHV-1100) is an antibody recruitment molecule. Noraramtide can specifically bind to CD38 molecules to recruit natural killer (NK) cells. Noraramtide enhances the ability of NK cells to kill tumor cells through antibody-dependent cellular cytotoxicity (ADCC). This mechanism allows NK cells to more effectively recognize and eliminate tumor cells while avoiding mutual killing between NK cells. Noraramtide can be used for the study of autologous cancer immunity .

HY-P3820

*[Dehydro-Pro4] Substance P (4-11)*	Neurokinin Receptor	Neurological Disease Inflammation/Immunology
[Dehydro-Pro4] Substance P (4-11) is a peptide fragment of Substance P. Substance P is a peptide mainly secreted by neurons. Substance P takes part in many biological processes, including nociception, inflammation and immunity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W013032

Oxamic acid Maximum Cited Publications 58 Publications Verification Oxamidic acid	Microorganisms Source Classification	Lactate Dehydrogenase Apoptosis
Oxamic acid is a *lactate dehydrogenase-A* (LDH-A) inhibitor. Oxamic acid shows anti-tumor activity, and anti-proliferative activity against cancer cells, and can induce apoptosis .

HY-N10574

Queuine 1 Publications Verification	Alkaloids Microorganisms Pyrrole Alkaloids Source Classification	Bacterial
Queuine is a selective substrate for tRNA guanine transglycosylase (TGT) and can be incorporated into eukaryotic tRNA. Queuine promotes tRNA modification, affecting mitochondrial function and Warburg metabolic phenotype. If Queuine is deficient, aerobic glycolysis can be enhanced, oxidative phosphorylation can be inhibited, and Warburg metabolism can be promoted, accompanied by increased ammonia and lactate production and increased lactate dehydrogenase activity. Queuine can be used for autoimmune diseases (such as experimental models of multiple sclerosis) and cancer metabolic regulation, and its deficiency is associated with low tRNA modification in tumor cells .

HY-N7393

Isomalt Palatinitol	other families Metabolic Disease Plants Disease Research Fields Saccharides Source Classification	Environmental Pollutants Lactate Dehydrogenase
Isomalt (Palatinitol), a well-tolerated, non-toxic polyol and a protein-stabilizing excipient, stabilizes lactate dehydrogenase (LDH) moderately during freeze-drying, and performs better during storage. Isomalt is traditionally used as a sweetening agent in the food industry and as a tabletting excipient for pharmaceutical purposes .

HY-113098

2-Oxovaleric acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Lactate Dehydrogenase Drug Derivative
2-Oxovaleric acid is an analog of Pyruvate and a substrate inhibitor of *Lactate dehydrogenase, exhibiting substrate inhibitory activity against lactate dehydrogenase* from Phycomyces blakesleeanus .

HY-N10574A

Queuine dihydrochloride 1 Publications Verification	Alkaloids Microorganisms Pyrrole Alkaloids Source Classification	Others
Queuine dihydrochloride is a selective substrate for tRNA guanine transglycosylase (TGT) and can be incorporated into eukaryotic tRNA. Queuine dihydrochloride promotes tRNA modification, affecting mitochondrial function and Warburg metabolic phenotype. If Queuine dihydrochloride is deficient, aerobic glycolysis can be enhanced, oxidative phosphorylation can be inhibited, and Warburg metabolism can be promoted, accompanied by increased ammonia and lactate production and increased lactate dehydrogenase activity. Queuine dihydrochloride can be used for autoimmune diseases (such as experimental models of multiple sclerosis) and cancer metabolic regulation, and its deficiency is associated with low tRNA modification in tumor cells .

HY-N2177

3-Dehydrotrametenolic acid	Triterpenes Classification of Application Fields Terpenoids Polyporaceae Poria cocos Plants Disease Research Fields Source Classification Cancer	Lactate Dehydrogenase Apoptosis
3-Dehydrotrametenolic acid, isolated from the sclerotium of Poria cocos, is a lactate dehydrogenase (LDH) inhibitor. 3-Dehydrotrametenolic acid promotes adipocyte differentiation in vitro and acts as an insulin sensitizer in vivo. 3-Dehydrotrametenolic acid induces apoptosis and has anticancer activity .

HY-N2498

Glomeratose A	Classification of Application Fields Polygalaceae Other Diseases Other Phenylpropanoids Phenylpropanoids Plants Disease Research Fields Polygala tenuifolia Willd. Source Classification	Lactate Dehydrogenase
Glomeratose A is a *lactate dehydrogenase* inhibitor, isolated from Polygala tenuifolia .

HY-113383

2-Hydroxyvaleric acid	Source Classification	Endogenous Metabolite Lactate Dehydrogenase Biochemical Assay Reagents
2-Hydroxyvaleric acid is a medium chain α-hydroxy fatty acid. 2-Hydroxyvaleric acid is an activator in fat metabolism of palmitic acid-1-C ¹⁴. 2-hydroxyvaleric acid is also used as a staining agent for measuring tissue-specific *Lactate dehydrogenase* activity and elevated levels of 2-hydroxyvaleric acid induces lactic acidosis .

HY-W013032R

Oxamic acid (Standard) Oxamidic acid (Standard)	Microorganisms Source Classification	Reference Standards Lactate Dehydrogenase Apoptosis
Oxamic acid (Standard) is the analytical standard of Oxamic acid. This product is intended for research and analytical applications. Oxamic acid is a lactate dehydrogenase-A (LDH-A) inhibitor. Oxamic acid shows anti-tumor activity, and anti-proliferative activity against cancer cells, and can induce apoptosis[1][2][3].

HY-N7393R

Isomalt (Standard) Palatinitol (Standard)	other families Plants Saccharides Source Classification	Reference Standards Lactate Dehydrogenase
Isomalt (Standard) is the analytical standard of Isomalt. This product is intended for research and analytical applications. Isomalt (Palatinitol), a well-tolerated, non-toxic polyol and a protein-stabilizing excipient, stabilizes lactate dehydrogenase (LDH) moderately during freeze-drying, and performs better during storage. Isomalt is traditionally used as a sweetening agent in the food industry and as a tabletting excipient for pharmaceutical purposes .

Species:	Human (3) Rat (1) Mouse (2) E.coli (1)
Tag:	His (9)
Source:	HEK293 (1) Sf9 insect cells (1) E. coli (7)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P70259

	LDHA Protein, Mouse (HEK293, His) rMuL-lactate dehydrogenase, His; LDHA; Ldh1; L-lactate dehydrogenase	Mouse	HEK293
	LDHA protein catalyzes the simultaneous and stereospecific interconversion of pyruvate and lactate, accompanied by the reciprocal interconversion of NADH and NAD(+).LDHA Protein, Mouse (HEK293, His) is the recombinant mouse-derived LDHA protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P71522

	IIdD Protein, E.coli (His) lldD; EcHS_A3817L-lactate dehydrogenase	E.coli	E. coli
	GLO1/Glyoxalase I Protein catalyzes the conversion of hemimercaptal to S-lactoylglutathione, detoxifying cytotoxic methylglyoxal produced in glycolysis. Beyond detoxification, GLO1 regulates NF-kappa-B transcriptional activity in TNF-induced pathways, indicating its role in inflammation. Additionally, GLO1 is crucial for normal osteoclastogenesis, emphasizing its broader involvement in cellular processes. IIdD Protein, E.coli (His) is the recombinant E. coli-derived IIdD protein, expressed by E. coli , with N-His labeled tag.

HY-P77134

	LDH Protein, P. falciparum (His) L-lactate dehydrogenase; PF3D7_1324900	Others	E. coli
	The pfHPRT (Plasmodium falciparum hypoxanthine-guanine phosphoribosyltransferase) protein is a member of the LDH/MDH (lactate dehydrogenase/malate dehydrogenase) superfamily. It plays a crucial role in the purine metabolism salvage pathway of the malaria-causing parasite Plasmodium falciparum. LDH Protein, P. falciparum (His) is the recombinant LDH protein, expressed by E. coli , with C-His labeled tag.

HY-P74637

	HPRT Protein, P. falciparum (His) L-lactate dehydrogenase; PF3D7_1324900	Others	E. coli
	The pfHPRT (Plasmodium falciparum hypoxanthine-guanine phosphoribosyltransferase) protein is a member of the LDH/MDH (lactate dehydrogenase/malate dehydrogenase) superfamily. It plays a crucial role in the purine metabolism salvage pathway of the malaria-causing parasite Plasmodium falciparum. HPRT Protein, P. falciparum (His) is the recombinant HPRT protein, expressed by E. coli , with N-His labeled tag.

HY-P70265

	LDHB Protein, Human (His) rHuL-lactate dehydrogenase B chain/LDH-B, His; L-lactate Dehydrogenase B Chain; LDH-B; LDH Heart Subunit; LDH-H; Renal Carcinoma Antigen NY-REN-46; LDHB	Human	E. coli
	The LDHB protein, also known as lactate dehydrogenase B, is an enzyme that plays a crucial role in cellular energy metabolism. References indicate that the LDHB protein effectively catalyzes the simultaneous, stereospecific interconversion of pyruvate and lactate. LDHB Protein, Human (His) is the recombinant human-derived LDHB protein, expressed by E. coli , with N-6*His labeled tag.

HY-P73271

	LDHA Protein, Rat (His) L-lactate dehydrogenase A chain; LDH-A; LDH-M; Ldha; Ldh-1	Rat	E. coli
	The LDHA protein facilitates the simultaneous and stereospecific interconversion of pyruvate and lactate, accompanied by the concomitant exchange of NADH and NAD(+).LDHA Protein, Rat (His) is the recombinant rat-derived LDHA protein, expressed by E.coli , with N-His labeled tag.

HY-P73270

	LDHA Protein, Mouse (His) L-lactate dehydrogenase A chain; LDH-A; LDH-M; Ldha; Ldh-1	Mouse	E. coli
	LDHA protein catalyzes the simultaneous and stereospecific interconversion of pyruvate and lactate, accompanied by the reciprocal interconversion of NADH and NAD(+).LDHA Protein, Mouse (His) is the recombinant mouse-derived LDHA protein, expressed by E.coli , with N-His labeled tag.

HY-P70225

	LDHA Protein, Human (His) rHuL-lactate dehydrogenase A chain/LDH-A, His; L-Lactate Dehydrogenase A Chain; LDH-A; Cell Proliferation-Inducing Gene 19 Protein; LDH Muscle Subunit; LDH-M; Renal Carcinoma Antigen NY-REN-59; LDHA	Human	E. coli
	LDHA protein catalyzes the stereospecific interconversion of pyruvate and lactate, concomitantly exchanging NADH and NAD(+). LDHA Protein, Human (His) is the recombinant human-derived LDHA protein, expressed by E. coli , with N-6*His labeled tag.

HY-P702855

	LDHC Protein, Human (sf9, His) L-lactate dehydrogenase C chain; EC:1.1.1.27; Cancer/testis antigen 32; CT32; LDH testis subunit; LDH-X; LDH3; LDHX	Human	Sf9 insect cells
	LDHC Protein, Human (sf9, His) is the recombinant human-derived LDHC, expressed by Sf9 insect cells , with N-6*His labeled tag. ,

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Cat. No.	Product Name	Chemical Structure

HY-W040073S

Nifurtimox-d4
Nifurtimox-d₄ is deuterium labeled Nifurtimox. Nifurtimox, an antiprotozoal agent, which is generally used for the treatment of infections with Trypanosoma cruzi, has been used in the therapy of neuroblastoma. Nifurtimox affects enzyme activity of lactate dehydrogenase (LDH).

Host:	Rabbit (12)
Reactivity:	Human (12) Rat (7) Mouse (7)
Application:	IHC-P (10) ICC/IF (9) IP (8) IHC-F (4) WB (12) FC (2) ELISA (2)
Isotype:	IgG (12)
Conjugation:	Non-conjugated (12)
Clonality:	polyclonal (1) Monoclonal (8) Recombinant (6)
Modification:	Unmodified (9)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P80422

	Lactate Dehydrogenase Antibody (YA316)	WB, ICC/IF, IHC-P, FC, IP	Human, Mouse
	Lactate Dehydrogenase Antibody (YA316) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Lactate Dehydrogenase.

HY-P86942

	LDHD Antibody (YA6635) D lactate dehydrogenase antibody; DLD antibody; Lactate dehydrogenase D antibody; Ldhd antibody; LDHD_HUMAN antibody; MGC57726 antibody; mitochondrial antibody; Probable D lactate dehydrogenase mitochondrial antibody; Probable D-lactate dehydrogenase antibody;	WB, ICC/IF, IHC-P	Human, Mouse, Rat
	LDHD Antibody (YA6635) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to LDHD.

HY-P80994

	Lactate Dehydrogenase A Antibody (YA3482)	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	Lactate Dehydrogenase A Antibody (YA3482) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Lactate Dehydrogenase A.

HY-P86628

	Lactate Dehydrogenase Isoenzyme V Antibody (YA6320)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Lactate Dehydrogenase Isoenzyme V Antibody (YA6320) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Lactate Dehydrogenase Isoenzyme V.

HY-P80994A

	Lactate Dehydrogenase A Antibody (YA3482)(PBS only)	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	Lactate Dehydrogenase A Antibody (YA3482) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Lactate Dehydrogenase A.

HY-P810486

	Lactate Dehydrogenase C Antibody CT32, LDH3, LDHX, Cell proliferation-inducing gene 19 protein, GSD11, L lactate dehydrogenase B chain,	WB, IHC-P	Human, Mouse
	Lactate Dehydrogenase C Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Lactate Dehydrogenase C.

HY-P80739

	Lactate Dehydrogenase C Antibody (YA315) CT32; LDH3; LDHX	WB	Human
	Lactate Dehydrogenase C Antibody (YA315) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Lactate Dehydrogenase C.

HY-P80739A

	Lactate Dehydrogenase C Antibody (YA315)(PBS only) CT32; LDH3; LDHX	WB	Human
	Lactate Dehydrogenase C Antibody (YA315) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Lactate Dehydrogenase C.

HY-P86602

	Lactate Dehydrogenase Antibody (YA6294) LDHA; PIG19; LDHB; LDHC; LDH3; LDHX; L-lactate dehydrogenase A chain; LDH-A; Cell proliferation-inducing gene 19 protein; LDH muscle subunit; LDH-M; Renal carcinoma antigen NY-REN-59; L-lactate dehydrogenase B chain; LDH-B; LDH heart subunit; LDH-H; Renal carcinoma antigen NY-REN-46; L-lactate dehydrogenase C chain; LDH-C; Cancer/testis antigen 32; CT32; LDH testis subunit; LDH-X;	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Lactate Dehydrogenase Antibody (YA6294) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Lactate Dehydrogenase.

HY-P80738

	Lactate Dehydrogenase A Antibody (YA317) LDHA; LDH-M; LDH1; PIG19; GSD11; TRG5; Proliferation inducing gene 19	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Rat
	Lactate Dehydrogenase A Antibody (YA317) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Lactate Dehydrogenase A.

HY-P82325

	Lactate Dehydrogenase B Antibody (YA2070) HEL S 281; LDH B; LDH H; LDH-B; LDH-H; LDHB; LDHBD; LDHH; TRG5	WB, IHC-P, ICC/IF, IP, FC	Human
	Lactate Dehydrogenase B Antibody (YA2070) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Lactate Dehydrogenase B.

HY-P80738A

	Lactate Dehydrogenase A Antibody (YA317)(PBS only) LDHA; LDH-M; LDH1; PIG19; GSD11; TRG5; Proliferation inducing gene 19	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Rat
	Lactate Dehydrogenase A Antibody (YA317) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Lactate Dehydrogenase A.

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Cat. No.	Product Name		Classification

HY-132606A

Nedosiran sodium DCR-PHXC sodium		siRNAs siRNA drugs
Nedosiran (DCR-PHXC) sodium is an RNA interference (RNAi) targeting lactate dehydrogenase (LDH). Nedosiran sodium represents an impactful potential therapeutic for primary hyperoxaluria (PH) with end-stage renal disease (ESRD). Nedosiran sodium is a GalNAc-dsRNA conjugate .

HY-132606

Nedosiran DCR-PHXC		siRNAs siRNA drugs
Nedosiran (DCR-PHXC) is an RNA interference (RNAi) targeting lactate dehydrogenase (LDH). Nedosiran represents an impactful potential therapeutic for primary hyperoxaluria (PH) with end-stage renal disease (ESRD). Nedosiran is a GalNAc-dsRNA conjugate .

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