2. Metabolic Enzyme/Protease Apoptosis NF-κB Immunology/Inflammation
  3. Lactate Dehydrogenase Apoptosis Reactive Oxygen Species (ROS) SOD
  4. LDH-IN-5

LDH-IN-5 is a Lactate Dehydrogenase (LDH) inhibitor with neuroprotective activity. LDH-IN-5 can inhibit cell apoptosis, reduce ROS, MDA production and increases superoxide dismutase (SOD) activity. LDH-IN-5 can be used for the research of neurological disease, such as ischemic stroke.

For research use only. We do not sell to patients.

LDH-IN-5

LDH-IN-5 Chemical Structure

CAS No. : 2768522-31-0

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LDH-IN-5 Related Antibodies

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Description

LDH-IN-5 is a Lactate Dehydrogenase (LDH) inhibitor with neuroprotective activity. LDH-IN-5 can inhibit cell apoptosis, reduce ROS, MDA production and increases superoxide dismutase (SOD) activity. LDH-IN-5 can be used for the research of neurological disease, such as ischemic stroke[1].

In Vitro

LDH-IN-5 (Compound s6b) (12.5-50 μM, 6h) significantly increases cell viability and reduces LDH release in mouse hippocampal neuron HT22 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

LDH-IN-5 Related Antibodies
In Vivo

LDH-IN-5 (Compound s6b) (125-500 μg/mL, 18 h) significantly reduces the incidence of cerebral thrombosis in 2dpf albino zebrafish models induced by Ponatinib (HY-12047)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 2dpf albino zebrafish models induced by Ponatinib (HY-12047)[1]
Dosage: 125-500 μg/mL
Administration: 18 h
Result: Showed the thrombosis incidence decreases by 97% in the 125 μg/mL dose group and 77% in the 500 μg/mL dose group.
Showed no zebrafish death or obvious toxicity at 500 μg/mL.
Molecular Weight

659.69

Formula

C36H51BrO6
CAS No.
SMILES

CC1(C)[C@@]2(C)[C@H](OC(CCC(O[C@H](C3=CC=C(Br)C=C3C(O[C@H]4[C@@](C5(C)C)(C)CC[C@H]5C4)=O)CCCC)=O)=O)C[C@@H]1CC2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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LDH-IN-5 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LDH-IN-52768522-31-0Lactate DehydrogenaseApoptosisReactive Oxygen Species (ROS)SODLDHSuperoxide DismutaseapoptosisROSMDAischemic strokeHT22Inhibitorinhibitorinhibit

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