Lactate dehydrogenase, porcine heart
Based on 1 Customer Validation
Lactate Dehydrogenase (LDH), Porcine Heart, is an isoenzyme of lactate dehydrogenase derived from porcine heart. Lactate Dehydrogenase (LDH), Porcine Heart, is primarily used in life science research, tissue damage diagnosis, and as an enzyme marker.
For research use only. We do not sell to patients.
- CAS No.: 9001-60-9
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Lactate Dehydrogenase (LDH), Porcine Heart (LDH), binds specifically and with high affinity to acidic phospholipids through highly conserved NADH binding sites on each of its subunits. This interaction is precisely regulated in cellular environments with low pH and high NADH concentrations. When cellular energy is sufficient (high NADH levels), binding is inhibited, and the enzyme remains in a free active state. When cells are under stress (e.g., ischemia leading to a decrease in pH and NADH depletion), binding occurs, and enzyme activity is inhibited[2].
Lactate Dehydrogenase (LDH) is released into the bloodstream due to myocardial tissue damage, and its increased activity can serve as a biochemical indicator for assessing myocardial infarction[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 9001-60-9
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Appearance Solid
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Color White to off-white
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SMILES
[Lactate dehydrogenase, porcine heart]
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Synonyms
LAD, LD, LDH
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (264 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Pfleiderer G, et al. Limited proteolysis of lactate dehydrogenase from porcine heart with trypsin: characterization and reactivation of the fragments. Experientia. 1991 May 15;47(5):470-5. [Content Brief]
[2]. Terlecki G, et al. Ultracentrifugation studies of the location of the site involved in the interaction of pig heart lactate dehydrogenase with acidic phospholipids at low pH. A comparison with the muscle form of the enzyme. Cell Mol Biol Lett. 2007 Sep;12(3):378-95. [Content Brief]
[3]. KING J, WAIND AP. Lactic dehydrogenase activity in acute myocardial infarction. Br Med J. 1960 Nov 5;2(5209):1361-3. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Lactate dehydrogenase, porcine heart Related Classifications
HY-P2807A Related Classifications
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