NCATS-SM1441

Cat. No.: HY-151243 Purity: 98.65%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

NCATS-SM1441 (compound 52) is a lactate dehydrogenase (LDH) inhibitor (IC₅₀=40 nM). By inhibiting the activity of LDH, NCATS-SM1441 is able to reduce the production of lactic acid in cancer cells, helping to slow or stop the proliferation of cancer cells. NCATS-SM1441 can be used to study cancer metabolism.

For research use only. We do not sell to patients.

NCATS-SM1441 Chemical Structure

CAS No. : 1964517-04-1

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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This product is a controlled substance and not for sale in your territory.

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Description

Cellular Effect

Cell Line	Type	Value	Description	References
A673	IC₅₀	105 nM Compound: 52; NACTS-SM1441	Cytotoxicity against human A673 cells assessed as reduction in cell viability after 48 hrs by CellTiter-Glo assay Cytotoxicity against human A673 cells assessed as reduction in cell viability after 48 hrs by CellTiter-Glo assay	[PMID: 32902275]
MIA PaCa-2	IC₅₀	347 nM Compound: 52; NACTS-SM1441	Cytotoxicity against human MIA PaCa-2 cells assessed as reduction in cell viability after 48 hrs by CellTiter-Glo assay Cytotoxicity against human MIA PaCa-2 cells assessed as reduction in cell viability after 48 hrs by CellTiter-Glo assay	[PMID: 32902275]

Molecular Weight

632.75

Formula

C₃₁H₂₅FN₄O₄S₃

CAS No.

1964517-04-1

Appearance

Solid

Color

White to light yellow

SMILES

O=C(C1=CSC(N2N=C(C(CC3=CC=C(S(=O)(N)=O)C(F)=C3)=C2CC4CC4)C5=CC(C#CC6=CC=C(C)S6)=CC=C5)=N1)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (158.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.5804 mL	7.9020 mL	15.8040 mL
5 mM	0.3161 mL	1.5804 mL	3.1608 mL
10 mM	0.1580 mL	0.7902 mL	1.5804 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.65%

Select Batch:

Data Sheet (274 KB) SDS (251 KB)

COA (255 KB) HNMR (281 KB) RP-HPLC (258 KB) LCMS (112 KB)

Handling Instructions (2659 KB)

References

[1]. Rai G, et al. Pyrazole-based lactate dehydrogenase inhibitors with optimized cell activity and pharmacokinetic properties[J]. Journal of medicinal chemistry, 2020, 63(19): 10984-11011. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.5804 mL	7.9020 mL	15.8040 mL	39.5101 mL
	5 mM	0.3161 mL	1.5804 mL	3.1608 mL	7.9020 mL
	10 mM	0.1580 mL	0.7902 mL	1.5804 mL	3.9510 mL
	15 mM	0.1054 mL	0.5268 mL	1.0536 mL	2.6340 mL
	20 mM	0.0790 mL	0.3951 mL	0.7902 mL	1.9755 mL
	25 mM	0.0632 mL	0.3161 mL	0.6322 mL	1.5804 mL
	30 mM	0.0527 mL	0.2634 mL	0.5268 mL	1.3170 mL
	40 mM	0.0395 mL	0.1976 mL	0.3951 mL	0.9878 mL
	50 mM	0.0316 mL	0.1580 mL	0.3161 mL	0.7902 mL
	60 mM	0.0263 mL	0.1317 mL	0.2634 mL	0.6585 mL
	80 mM	0.0198 mL	0.0988 mL	0.1976 mL	0.4939 mL
	100 mM	0.0158 mL	0.0790 mL	0.1580 mL	0.3951 mL

NCATS-SM1441 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NCATS-SM14411964517-04-1Lactate DehydrogenaseLDHInhibitorWarburg effectcancer cell metabolismlactate dehydrogenaseinhibitorinhibit

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NCATS-SM1441

NCATS-SM1441 Related Antibodies

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