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antiarrhythmic+agent

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (12) Antibiotic (1) Apoptosis (10) Autophagy (13) Bacterial (1) Biochemical Assay Reagents (3) Calcium Channel (14) Caspase (2) Cytochrome P450 (13) Dopamine β-hydroxylase (1) Drug Derivative (2) Drug Isomer (1) Drug Metabolite (3) Endogenous Metabolite (2) Fungal (1) Isotope-Labeled Compounds (14) mAChR (7) nAChR (1) P-glycoprotein (2) Parasite (10) PARP (2) Potassium Channel (71) Reference Standards (21) SARS-CoV (1) Sodium Channel (49)
By Research Areas:	Cancer (17) Cardiovascular Disease (128) Endocrinology (1) Infection (14) Inflammation/Immunology (1) Metabolic Disease (2) Neurological Disease (18)

By Targets:

Adrenergic Receptor (12)

Antibiotic (1)

Apoptosis (10)

Autophagy (13)

Bacterial (1)

Biochemical Assay Reagents (3)

Calcium Channel (14)

Caspase (2)

Cytochrome P450 (13)

Dopamine β-hydroxylase (1)

Drug Derivative (2)

Drug Isomer (1)

Drug Metabolite (3)

Endogenous Metabolite (2)

Fungal (1)

Isotope-Labeled Compounds (14)

mAChR (7)

nAChR (1)

P-glycoprotein (2)

Parasite (10)

PARP (2)

Potassium Channel (71)

Reference Standards (21)

SARS-CoV (1)

Sodium Channel (49)

By Research Areas:

Cancer (17)

Cardiovascular Disease (128)

Endocrinology (1)

Infection (14)

Inflammation/Immunology (1)

Metabolic Disease (2)

Neurological Disease (18)

134

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0232

Dofetilide 5+ Cited Publications UK 68789	Potassium Channel	Cardiovascular Disease
Dofetilide (UK 68789), as a class III antiarrhythmic agent, is an orally active, potent and specific IKr blocker. Dofetilide can be used for the research of cardiovascular disease .

HY-B1751

Quinidine (15% dihydroquinidine) 20+ Cited Publications	Potassium Channel Cytochrome P450 Apoptosis Parasite	Infection Cardiovascular Disease Cancer
Quinidine (15% dihydroquinidine) is an antiarrhythmic agent. Quinidine is a potent, orally active, selective cytochrome P450db inhibitor. Quinidine is also a K ⁺ channel blocker with an IC₅₀ of 19.9 μM, and can induce apoptosis. Quinidine can be used for malaria research .

HY-17429

Flecainide acetate 3 Publications Verification R-818	Sodium Channel	Cardiovascular Disease
Flecainide acetate (R-818) is a class 1C antiarrhythmic agent especially used for the management of supraventricular arrhythmia; works by blocking the Nav1.5 sodium channel in the heart, causing prolongation of the cardiac action potential.

HY-W010950

Flecainide 3 Publications Verification	Potassium Channel Sodium Channel	Cardiovascular Disease
Flecainide is an orally active antiarrhythmic agent. Flecainide can block sodium channels and inhibit calcium ion release mediated by the cardiac ryanodine receptor (RyR2). Flecainide can be used in the research of diseases such as catecholaminergic polymorphic ventricular tachycardia (CPVT) .

HY-B1751B

Quinine sulfate 5+ Cited Publications	Parasite Potassium Channel Cytochrome P450	Infection Cardiovascular Disease Cancer
Quinidine sulfate is an antiarrhythmic agent. Quinidine sulfate is a potent, orally active, selective cytochrome P450db inhibitor. Quinidine sulfate is also a K ⁺ channel blocker with an IC₅₀ of 19.9 μM. Quinidine sulfate can be used for malaria research .

HY-B0437

Sotalol hydrochloride 2 Publications Verification MJ 1999	Adrenergic Receptor Potassium Channel	Cardiovascular Disease Neurological Disease
Sotalol hydrochloride (MJ 1999) is an orally active, non-selective β-adrenergic receptor blocker. Sotalol hydrochloride is a potent antiarrhythmic agent that can be used for the research of pediatric arrhythmias. Sotalol hydrochloride blocks β-receptors, and potassium KCNH2 channels. Antiepileptic Agent .

HY-12533

Disopyramide 2 Publications Verification Dicorantil; SC-7031	Sodium Channel Potassium Channel	Cardiovascular Disease
Disopyramide (Dicorantil) is a class IA antiarrhythmic agent with efficacy in ventricular and atrial arrhythmias. Disopyramide blocks the fast inward sodium current of cardiac muscle and prolongs the duration of cardiac action potentials. Disopyramide inhibits HERG encoded potassium channels. Disopyramide also exhibits complex protein binding, and has a potent negative inotropic action .

HY-33350

Clofilium tosylate 1 Publications Verification	Potassium Channel Apoptosis	Cardiovascular Disease Cancer
Clofilium tosylate, a potassium channel blocker, induces apoptosis of human promyelocytic leukemia (HL-60) cells via Bcl-2-insensitive activation of caspase-3. Antiarrhythmic agent .

HY-135121

Ethacizine hydrochloride Ethacizin; NIK-244	Sodium Channel	Cardiovascular Disease
Ethacizine hydrochloride (Ethacizin; NIK-244) is a longer-lasting Class Ic antiarrhythmic agent than Flecainide . Ethacizine hydrochloride (Ethacizin; NIK-244) inhibits the depolarizing current responsible for the intraatrial and His-Purkinje-ventricular conduction .

HY-12533A

Disopyramide phosphate 2 Publications Verification Dicorantil phosphate; SC-7031 phosphate	Potassium Channel Sodium Channel	Cardiovascular Disease
Disopyramide phosphate is a class IA antiarrhythmic agent with efficacy in ventricular and atrial arrhythmias. Disopyramide phosphate blocks the fast inward sodium current of cardiac muscle and prolongs the duration of cardiac action potentials. Disopyramide phosphate inhibits HERG encoded potassium channels. Disopyramide phosphate also exhibits complex protein binding, and has a potent negative inotropic action .

HY-150123

Quinidine methiodide	Drug Metabolite	Cardiovascular Disease
Quinidine methiodide is a metabolite of Quinidine. Quinidine is an antiarrhythmic agent .

HY-W010950A

Flecainide hydrochloride 3 Publications Verification	Potassium Channel Sodium Channel	Cardiovascular Disease
Flecainide hydrochloride is an orally active antiarrhythmic agent. Flecainide hydrochloride can block sodium channels and inhibit calcium ion release mediated by the cardiac ryanodine receptor (RyR2). Flecainide hydrochloride can be used in the research of diseases such as catecholaminergic polymorphic ventricular tachycardia (CPVT) .

HY-B0772A

Nifekalant hydrochloride MS-551	Potassium Channel	Cardiovascular Disease
Nifekalant hydrochloride (MS-551), a class III antiarrhythmic agent, is a IKr potassium channel blocker with an IC₅₀ of 10 µM. Nifekalant hydrochloride can be used for refractory ventricular tachyarrhythmias research .

HY-14834A

Budiodarone tartrate ATI-2042 tartrate	Potassium Channel Sodium Channel Calcium Channel	Cardiovascular Disease
Budiodarone (ATI-2042) tartrate is a chemical analogue of Amiodarone (HY-14187) with balanced, multiple cardiac ion channel (potassium, sodium and calcium channels) inhibiting activity. Budiodarone tartrate is an antiarrhythmic agent .

HY-16952

Bepridil 5+ Cited Publications (±)-Bepridil; Org 5730	Calcium Channel Sodium Channel SARS-CoV	Infection Cardiovascular Disease
Bepridil ((±)-Bepridil) is a calcium channel blocking agent used as antiarrhythmic agent. Bepridil inhibits both calcium and sodium currents, has research potential in certain ischemia-induced ventricular arrhythmias. Bepridil also has strong inhibition of SARS-CoV-2 from entry and replication inside Vero E6 and A549 cells .

HY-101723

Modecainide BMY 40327; MJ 14030	Drug Metabolite	Cardiovascular Disease
Modecainide is a major metabolite of Encainide, which is an antiarrhythmic agent.

HY-101245

Pilsicainide hydrochloride SUN-1165; Pilzicainidehydrochloride	Sodium Channel	Cardiovascular Disease
Pilsicainide hydrochloride (SUN-1165) is an orally active sodium channel blocker and potent class Ic antiarrhythmic agent .

HY-B1751S

Quinidine-d3	Parasite	Infection Cardiovascular Disease
Quinidine-d₃ is the deuterium labeled Quinidine. Quinidine is an antiarrhythmic agent for the treatment of abnormal heart rhythms and also malaria.

HY-130353

Desethylamiodarone hydrochloride N-desethylamiodarone hydrochloride; LB 33020 hydrochloride	Potassium Channel Autophagy	Cardiovascular Disease
Desethylamiodarone hydrochloride (N-desethylamiodarone hydrochloride) is a major active metabolite of Amiodarone. Desethylamiodarone hydrochloride is formed by CYP3A isoenzymes. Amiodarone is an antiarrhythmic agent for inhibition of ATP-sensitive potassium channel with an IC₅₀ of 19.1 μM .

HY-107335

Aplodan Creatinol O-phosphate; Creatinol phosphate; Creatinolfosfate	Biochemical Assay Reagents	Cardiovascular Disease
Aplodan (Creatinol O-phosphate) is an antiischemic and antiarrhythmic agent. Aplodan has a protective action on cell membrane. Aplodan has the potential for the research of ischemic heart or acute myocardial infarction .

HY-130335

Encainide MJ9067	Sodium Channel	Cardiovascular Disease
Encainide (MJ9067) is an antiarrhythmic agent with class IC activity. Encainide blocks voltage-dependent potassium channels. Encainide has the potential for life-threatening ventricular arrhythmias, symptomatic ventricular arrhythmias and supraventricular arrhythmias research .

HY-126028A

(+)-Sotalol (S)-Sotalol	Adrenergic Receptor	Cardiovascular Disease Neurological Disease
(+)-Sotalol ((S)-Sotalol) is the S-isomer of Sotalol (HY-103196). Sotalol is an orally active, non-selective β-adrenergic receptor blocker. (+)-Sotalol is an antiarrhythmic agent. (+)-Sotalol can prolong action potential duration in isolated cardiac muscle .

HY-131987S

Ethacizine-d5	Isotope-Labeled Compounds Sodium Channel	Cardiovascular Disease
Ethacizine-d₅ is the deuterium labeled Ethacizine (HY-131987). Ethacizine is an antiarrhythmic agent with inhibitory activity on sodium channels.

HY-100795A

Pirmenol hydrochloride (±)-Pirmenol hydrochloride; CI-845	mAChR Potassium Channel	Cardiovascular Disease
Pirmenol ((±)-Pirmenol) hydrochloride is an orally active antiarrhythmic agent. Pirmenol hydrochloride inhibits I_K.ACh (IC₅₀: 0.1 μM) by blocking mAchR. Pirmenol hydrochloride can be used in the research of cardiovascular disease, such as atrial fibrillation .

HY-101436A

Sematilide hydrochloride CK-1752 hydrochloride	Potassium Channel	Cardiovascular Disease
Sematilide hydrochloride (CK-1752 hydrochloride) is a selective I_Kr channel blocker. Sematilide causes a concentration-dependent inhibition of the delayed rectifier K ⁺ current (IC₅₀=25 μM). Sematilide is a class III antiarrhythmic agent .

HY-B0437AS

Sotalol-d6 hydrochloride MJ 1999-d6 hydrochloride	Adrenergic Receptor Potassium Channel	Cardiovascular Disease Endocrinology
Sotalol-d₆ (hydrochloride) is a deuterium labeled Sotalol hydrochloride. Sotalol hydrochloride is an orally active, non-selective competitive β-adrenergic receptor blocker. Sotalol hydrochloride is a potent antiarrhythmic agent that can be used for the research of pediatric arrhythmias. Sotalol hydrochloride blocks β-receptors, and potassium KCNH2 channels .

HY-B1751D

Quinidine sulfate dihydrate	Cytochrome P450 Parasite Potassium Channel Apoptosis	Infection Cardiovascular Disease Cancer
Quinidine sulfate dihydrate is an antiarrhythmic agent. Quinidine sulfate dihydrate is a potent, orally active, selective cytochrome P450db inhibitor. Quinidine sulfate dihydrate is also a K ⁺ channel blocker with an IC₅₀ of 19.9 μM, and can induce apoptosis. Quinidine sulfate dihydrate can be used for malaria research .

HY-100572

Nicainoprol 1 Publications Verification RU-42924	Sodium Channel	Cardiovascular Disease
Nicainoprol is a fast-sodium-channel blocking agent, which is a potent antiarrhythmic agent.

HY-133715

Pilsicainide SUN 1165 free base; Pilzicainide	Sodium Channel	Cardiovascular Disease
Pilsicainide (SUN 1165 free acid) is a potent sodium channel blocker and potent class Ic antiarrhythmic agent .

HY-14187S

Amiodarone-d10 hydrochloride	Potassium Channel Autophagy	Cardiovascular Disease
Amiodarone-d₁₀ (hydrochloride) is the deuterium labeled Amiodarone. Amiodarone hydrochloride is an antiarrhythmic agent for inhibition of ATP-sensitive potassium channel with an IC₅₀ of 19.1 μM .

HY-106912A

L-706000 free base MK 499 free base	Potassium Channel	Cardiovascular Disease
L-706000 (MK 499) free base is a potent hERG channel blocker with an IC₅₀ of 32 nM. L-706000 free base is a class III antiarrhythmic agent that can be used for the study of malignant ventricular tachyarrhythmias .

HY-W010950S

Flecainide-d3	Potassium Channel Sodium Channel Isotope-Labeled Compounds	Cardiovascular Disease
Flecainide-d₃ is the deuterium labeled Flecainide. Flecainide is an orally active antiarrhythmic agent. Flecainide can block sodium channels and inhibit calcium ion release mediated by the cardiac ryanodine receptor (RyR2). Flecainide can be used in the research of diseases such as catecholaminergic polymorphic ventricular tachycardia (CPVT) .

HY-B0615AS

Moricizine-d8Hydrochloride EN 313-d₈; Ethmozin-d₈; Moracizine-d₈	Isotope-Labeled Compounds	Cardiovascular Disease
Moricizine-d₈ Hydrochloride is the deuterium labeled Moricizine Hydrochloride (HY-B0615A). Moricizine Hydrochloride is an orally active Class I antiarrhythmic agent. Moricizine Hydrochloride decreases the maximum rate of phase 0 depolarization; increases rates of phase 2 and 3 repolarization, decreases action potential duration, and decreases effective refractory period .

HY-117471

Antiarrhythmic agent-3	Endogenous Metabolite	Neurological Disease
Antiarrhythmic agent-3 is an antiarrhythmic drug with the activity of enhancing antiarrhythmic efficacy and improving inhibition index. The antiarrhythmic effect of antiarrhythmic agent-3 is related to its hydrophobicity (log P). The central nervous system toxicity of antiarrhythmic agent-3 is related to the combined effect of its hydrophobicity and acid constant (pKa) .

HY-116072

Antiarrhythmic agent-2	Calcium Channel	Cardiovascular Disease
Antiarrhythmic agent-2 is a nonspecific Ca ²⁺ inward current blocker that inhibits ionic currents in sensory neuron membranes. Antiarrhythmic agent-2 can be used in the study of cardiovascular diseases, such as arrhythmias .

HY-U00274

Ropitoin TR 2985	Drug Derivative	Cardiovascular Disease
Ropitoin (TR 2985) is a novel *antiarrhythmic* agent.

HY-U00232

Bidisomide SC40230	Sodium Channel	Cardiovascular Disease
Bidisomide (SC40230) is a class I antiarrhythmic agent.

HY-131987

Ethacizine	Sodium Channel	Cardiovascular Disease
Ethacizine is an antiarrhythmic agent with inhibitory activity on sodium channels .

HY-B0232S

Dofetilide-d4 UK 68789 d₄	Potassium Channel	Cardiovascular Disease
Dofetilide-d₄ is a deuterium labeled Dofetilide. Dofetilide is a class III antiarrhythmic agent.

HY-19049

CK-1649 chloride	Potassium Channel	Cardiovascular Disease
CK-1649 chloride is a class III antiarrhythmic agent. CK-1649 chloride can inhibit potassium channel activity .

HY-147256

Cavutilide Niferidil free base	Potassium Channel	Cardiovascular Disease
Cavutilide (Niferidil (free base)) is a class III antiarrhythmic agent that inhibits hERG K ⁺ channel. Cavutilide has the potential for the study of persistent atrial fibrillation .

HY-177361

Zocainone	Sodium Channel	Cardiovascular Disease
Zocainone is an antiarrhythmic agent. Zocainone blocks sodium channels in cardiac tissue, stabilizing the cardiac action potential and reducing abnormal electrical activity. Zocainone is promising for research of cardiac arrhythmias .

HY-B0772

Nifekalant MS-551 free base	Potassium Channel	Cardiovascular Disease
Nifekalant (MS-551), a class III antiarrhythmic agent, is a IKr potassium channel blocker with an IC₅₀ of 10 μM. Nifekalant can be used for refractory ventricular tachyarrhythmias research .

HY-100795

Pirmenol (±)-Pirmenol; CI-845 free base	mAChR Potassium Channel	Cardiovascular Disease
Pirmenol is an orally active antiarrhythmic agent. Pirmenol inhibits I_K.ACh (IC₅₀: 0.1 μM) by blocking mAchR. Pirmenol can be used in the research of cardiovascular disease, such as atrial fibrillation .

HY-14834

Budiodarone ATI-2042	Potassium Channel Sodium Channel Calcium Channel	Cardiovascular Disease
Budiodarone (ATI-2042) is an analogue of Amiodarone (HY-14187) with a half-life of 7 h. Budiodarone inhibits sodium, potassium, and calcium ion channels. Budiodarone is an antiarrhythmic agent and can be used for the research of atrial fibrillation .

HY-103196

Sotalol	Adrenergic Receptor Potassium Channel	Cardiovascular Disease Neurological Disease
Sotalol is an orally active, non-selective β-adrenergic receptor blocker. Sotalol is a potent antiarrhythmic agent that can be used for the research of pediatric arrhythmias. Sotalol blocks β-receptors, and potassium KCNH2 channels. Antiepileptic Agent .

HY-B1751C

Quinine hydrobromide	Parasite Cytochrome P450 Potassium Channel	Infection
Quinidine hydrobromide is an antiarrhythmic agent. Quinidine is a potent, orally active, selective cytochrome P450db inhibitor. Quinidine hydrobromide is also a K ⁺ channel blocker with an IC₅₀ of 19.9 μM. Quinidine hydrobromide can be used for malaria research .

HY-130353S

Desethyl Amiodarone-d4 hydrochloride	Isotope-Labeled Compounds Potassium Channel Autophagy	Cardiovascular Disease
Desethyl Amiodarone-d₄ (hydrochloride) is the deuterium labeled Desethylamiodarone hydrochloride. Desethylamiodarone hydrochloride (N-desethylamiodarone hydrochloride) is a major active metabolite of Amiodarone. Desethylamiodarone hydrochloride is formed by CYP3A isoenzymes. Amiodarone is an antiarrhythmic agent for inhibition of ATP-sensitive potassium channel with an IC₅₀ of 19.1 μM .

HY-B1751F

Quinidine gluconic acid	Parasite Potassium Channel Cytochrome P450 Apoptosis	Infection Cardiovascular Disease Cancer
Quinate is an antiarrhythmic agent. Quinate is a potent, orally active, selective cytochrome P450db inhibitor. Quinate is also a K ⁺ channel blocker with an IC₅₀ of 19.9 μM, and can induce apoptosis. Quinate can be used for malaria research .

HY-17429S

Flecainide-d4 acetate R-818-d₄	Sodium Channel	Cardiovascular Disease
Flecainide-d₄ (acetate) is the deuterium labeled Flecainide acetate. Flecainide acetate (R-818) is a class 1C antiarrhythmic agent especially used for the management of supraventricular arrhythmia; works by blocking the Nav1.5 sodium channel in the heart, causing prolongation of the cardiac action potential .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B1751

Quinidine (15% dihydroquinidine) 20+ Cited Publications	Cardiovascular Disease Alkaloids other families Classification of Application Fields Quinoline Alkaloids Plants Disease Research Fields Source Classification	Potassium Channel Cytochrome P450 Apoptosis Parasite
Quinidine (15% dihydroquinidine) is an antiarrhythmic agent. Quinidine is a potent, orally active, selective cytochrome P450db inhibitor. Quinidine is also a K ⁺ channel blocker with an IC₅₀ of 19.9 μM, and can induce apoptosis. Quinidine can be used for malaria research .

HY-B1302

Quinidine hydrochloride monohydrate 20+ Cited Publications	Cardiovascular Disease Structural Classification Natural Products Classification of Application Fields Rubiaceae Cinchona calisaya Wedd. Plants Disease Research Fields Source Classification	P-glycoprotein PARP Caspase Apoptosis Potassium Channel
Quinidine hydrochloride monohydrate is an orally active antiarrhythmic agent. Quinidine hydrochloride monohydrate reduces the expression level of P-gp, inhibits P-gp-mediated efflux, increases the intracellular accumulation of P-gp substrates, induces PARP cleavage and Caspase-3 activation, and elevates the proportion of Apoptotic cells at the sub-G1 phase. Quinidine hydrochloride monohydrate exerts sustained block and open-channel block effects on I_K(f). Quinidine hydrochloride monohydrate alters the urinary metabolic ratio of Amphetamine, modulates the Pentylenetetrazol-induced seizure threshold, and regulates the anticonvulsant effect of Dextromethorphan. Quinidine hydrochloride monohydrate can be used in studies related to uterine sarcoma and seizures .

HY-101245

Pilsicainide hydrochloride SUN-1165; Pilzicainidehydrochloride	Pyrrolizidine Alkaloids Alkaloids	Sodium Channel
Pilsicainide hydrochloride (SUN-1165) is an orally active sodium channel blocker and potent class Ic antiarrhythmic agent .

HY-B1751D

Quinidine sulfate dihydrate	Alkaloids other families Classification of Application Fields Quinoline Alkaloids Plants Disease Research Fields Source Classification Cancer	Cytochrome P450 Parasite Potassium Channel Apoptosis
Quinidine sulfate dihydrate is an antiarrhythmic agent. Quinidine sulfate dihydrate is a potent, orally active, selective cytochrome P450db inhibitor. Quinidine sulfate dihydrate is also a K ⁺ channel blocker with an IC₅₀ of 19.9 μM, and can induce apoptosis. Quinidine sulfate dihydrate can be used for malaria research .

HY-B1751R

Quinidine (15% dihydroquinidine) (Standard)	Alkaloids Structural Classification other families Quinoline Alkaloids Plants Source Classification	Reference Standards Potassium Channel Cytochrome P450 Apoptosis Parasite
Quinidine (15% dihydroquinidine) (Standard) is the analytical standard of Quinidine (15% dihydroquinidine). This product is intended for research and analytical applications. Quinidine (15% dihydroquinidine) is an antiarrhythmic agent. Quinidine is a potent, orally active, selective cytochrome P450db inhibitor. Quinidine is also a K+ channel blocker with an IC50 of 19.9 μM, and can induce apoptosis. Quinidine can be used for malaria research .

HY-B1304

(-)-Sparteine sulfate pentahydrate (-)-Lupinidine sulfate pentahydrate	Cardiovascular Disease Classification of Application Fields Disease Research Fields	Sodium Channel
(-)-Sparteine sulfate pentahydrate ((-)-Lupinidine sulfate pentahydrate) is a class 1a antiarrhythmic agent and a sodium channel blocker.

HY-B0997R

Hydroquinidine (Standard) Dihydroquinidine (Standard); (+)-Hydroquinidine (Standard); Hydroconquinine (Standard)	Alkaloids Structural Classification Rubiaceae Cinchona calisaya Wedd. Quinoline Alkaloids Plants Source Classification	Reference Standards Others
Hydroquinidine (Standard) is the analytical standard of Hydroquinidine. This product is intended for research and analytical applications. Hydroquinidine (Dihydroquinidine) is a derivative of Quinidine (an antiarrhythmic agent). Hydroquinidine prolongs the QT interval and has antiarrhythmic efficacy .

HY-126562R

Piperlonguminine (Standard)	Alkaloids Structural Classification Capsicum annuum L. Other Alkaloids Solanaceae Plants Source Classification	Reference Standards Bacterial Fungal Antibiotic
Sotalol (hydrochloride) (Standard) is the analytical standard of Sotalol (hydrochloride). This product is intended for research and analytical applications. Sotalol hydrochloride (MJ 1999) is an orally active, non-selective β-adrenergic receptor blocker. Sotalol hydrochloride is a potent antiarrhythmic agent that can be used for the research of pediatric arrhythmias. Sotalol hydrochloride blocks β-receptors, and potassium KCNH2 channels. Antiepileptic Agent .

HY-B1167A

Ajmaline hydrochloride Cardiorythmine hydrochloride; (+)-Ajmaline hydrochloride	Rauvolfia verticillata (Lour.) Baill. Apocynaceae Natural Products Plants Source Classification	Others
Ajmaline hydrochloride is a Class Ia antiarrhythmic agent. It inhibits HERG potassium channels with IC50s of 1.0 μmol/l and 42.3 μmol/l in HEK cells and moth spider oocytes respectively. The inhibitory effect of Ajmaline hydrochloride is rapid, reversible, and positive frequency dependent. It acts primarily on the open state of the HERG channel and may also be combined with the inactivated state. The inhibitory effect of ajmaline hydrochloride is dependent on aromatic residues in the S6 domain, and the sensitivity is significantly reduced in the inactivation-deficient HERG S620T channel. It can also slightly affect the activation voltage of HERG channels. Ajmaline hydrochloride's inhibitory effect on HERG channels may contribute to both its potent antiarrhythmic effects and its potential proarrhythmic risk.

Cat. No.	Product Name	Chemical Structure

HY-B1751S

Quinidine-d3
Quinidine-d₃ is the deuterium labeled Quinidine. Quinidine is an antiarrhythmic agent for the treatment of abnormal heart rhythms and also malaria.

HY-131987S

Ethacizine-d5
Ethacizine-d₅ is the deuterium labeled Ethacizine (HY-131987). Ethacizine is an antiarrhythmic agent with inhibitory activity on sodium channels.

HY-B0437AS

Sotalol-d6 hydrochloride
Sotalol-d₆ (hydrochloride) is a deuterium labeled Sotalol hydrochloride. Sotalol hydrochloride is an orally active, non-selective competitive β-adrenergic receptor blocker. Sotalol hydrochloride is a potent antiarrhythmic agent that can be used for the research of pediatric arrhythmias. Sotalol hydrochloride blocks β-receptors, and potassium KCNH2 channels .

HY-14187S

Amiodarone-d10 hydrochloride
Amiodarone-d₁₀ (hydrochloride) is the deuterium labeled Amiodarone. Amiodarone hydrochloride is an antiarrhythmic agent for inhibition of ATP-sensitive potassium channel with an IC₅₀ of 19.1 μM .

HY-W010950S

Flecainide-d3
Flecainide-d₃ is the deuterium labeled Flecainide. Flecainide is an orally active antiarrhythmic agent. Flecainide can block sodium channels and inhibit calcium ion release mediated by the cardiac ryanodine receptor (RyR2). Flecainide can be used in the research of diseases such as catecholaminergic polymorphic ventricular tachycardia (CPVT) .

HY-B0615AS

Moricizine-d8Hydrochloride
Moricizine-d₈ Hydrochloride is the deuterium labeled Moricizine Hydrochloride (HY-B0615A). Moricizine Hydrochloride is an orally active Class I antiarrhythmic agent. Moricizine Hydrochloride decreases the maximum rate of phase 0 depolarization; increases rates of phase 2 and 3 repolarization, decreases action potential duration, and decreases effective refractory period .

HY-B0232S

Dofetilide-d4
Dofetilide-d₄ is a deuterium labeled Dofetilide. Dofetilide is a class III antiarrhythmic agent.

HY-130353S

Desethyl Amiodarone-d4 hydrochloride

Desethyl Amiodarone-d₄ (hydrochloride) is the deuterium labeled Desethylamiodarone hydrochloride. Desethylamiodarone hydrochloride (N-desethylamiodarone hydrochloride) is a major active metabolite of Amiodarone. Desethylamiodarone hydrochloride is formed by CYP3A isoenzymes. Amiodarone is an antiarrhythmic agent for inhibition of ATP-sensitive potassium channel with an IC₅₀ of 19.1 μM .

HY-17429S

Flecainide-d4 acetate
Flecainide-d₄ (acetate) is the deuterium labeled Flecainide acetate. Flecainide acetate (R-818) is a class 1C antiarrhythmic agent especially used for the management of supraventricular arrhythmia; works by blocking the Nav1.5 sodium channel in the heart, causing prolongation of the cardiac action potential .

HY-14188S

Amiodarone-d4 hydrochloride

Amiodarone-d₄ (hydrochloride) is the deuterium labeled Amiodarone hydrochloride. Amiodarone hydrochloride, a benzofuran-based Class III antiarrhythmic agent, inhibits WT outwardIhERG tails with an IC₅₀ of ～45 nM . Amiodarone hydrochloride induces cell proliferation and myofibroblast differentiation via ERK1/2 and p38 MAPK signaling in fibroblasts . Amiodarone hydrochloride can be used in the research of both supraventricular and ventricular arrhythmias .

HY-A0016S

Dronedarone-d6 hydrochloride

Dronedarone-d₆ (hydrochloride) is the deuterium labeled Dronedarone. Dronedarone hydrochloride, a derivative of Amiodarone (HY-14187), is a class III antiarrhythmic agent for the study of atrial fibrillation (AF) and atrial flutter. Dronedarone hydrochloride is a potent blocker of multiple ion currents, including potassium current, sodium current, and L-type calcium current, and exhibits antiadrenergic effects by noncompetitive binding to β-adrenergic receptors. Dronedarone hydrochloride is a substrate for and a moderate inhibitor of CYP3A4 .

HY-A0084S

Procainamide-d4 hydrochloride
Procainamide-d₄ hydrochloride is deuterated labeled Procainamide. Procainamide hydrochloride is an antiarrhythmic agent used in the study of cardiac arrhythmias.

HY-14187S1

Amiodarone-d5 hydrochloride
Amiodarone-d₅ hydrochloride is deuterated labeled Amiodarone (HY-14187). Amiodarone is an antiarrhythmic agent for inhibition of ATP-sensitive potassium channel with an IC₅₀ of 19.1 μM.

HY-106577AS

(-)-(S)-Cibenzoline-d4
(-)-(S)-Cibenzoline-d₄ (Escibenzoline-d₄) is deuterium labeled (-)-(S)-Cibenzoline. (-)-(S)-Cibenzoline (Escibenzoline), a S(+)-enantiomer of Cibenzoline, is an antiarrhythmic agent .

HY-B0437S

Sotalol-d6
Sotalol-d₆ is the deuterium labeled Sotalol. Sotalol is an orally active, non-selective β-adrenergic receptor blocker. Sotalol is a potent antiarrhythmic agent that can be used for the research of pediatric arrhythmias. Sotalol blocks β-receptors, and potassium KCNH2 channels. Antiepileptic Agent .

HY-119521S

Mexiletine-d3

Mexiletine-d₃ (KOE-1173-d₃) is deuterium labeled Mexiletine. Mexiletine is an orally effective antiarrhythmic agent which has also been found to be effective for myotonia and neuropathic pain. Mexiletine exerts its efficacy through blocking sodium channels (IC₅₀ : 75±8 μM for tonic block, 23.6±2.8 μM for use-dependent block), therefore can be used for cardiovascular and neurological research .

HY-A0016S3

Dronedarone-d6

Dronedarone-d₆ (SR 33589-d₆) is deuterium labeled Dronedarone. Dronedarone (SR 33589), a derivative of amiodarone (HY-14187), is a class III antiarrhythmic agent for the study of atrial fibrillation (AF) and atrial flutter. Dronedarone is a potent blocker of multiple ion currents, including potassium current, sodium current, and L-type calcium current, and exhibits antiadrenergic effects by noncompetitive binding to β-adrenergic receptors. Dronedarone is a substrate for and a moderate inhibitor of CYP3A4 .

HY-119521S1

Mexiletine-d6

Mexiletine-d₆ (KOE-1173-d₆) is deuterium labeled Mexiletine. Mexiletine is an orally effective antiarrhythmic agent which has also been found to be effective for myotonia and neuropathic pain. Mexiletine exerts its efficacy through blocking sodium channels (IC₅₀ : 75±8 μM for tonic block, 23.6±2.8 μM for use-dependent block), therefore can be used for cardiovascular and neurological research .

HY-18600AS

Azimilide-d8 dihydrochloride

Azimilide-d₈ (NE-10064-d₈) dihydrochloride is the deuterium labeled Azimilide dihydrochloride (HY-18600A). Azimilide dihydrochloride is a class III antiarrhythmic agent, which works by blocking potassium channels in the heart. Azimilide dihydrochloride is a dual blocker of I_Ks (IC₅₀ = 2.6 μM (2mM [K⁺]ₑ)) and I_Kr (IC₅₀ = 1 μM (4 mM [K⁺])). Azimilide dihydrochloride blocked HERG channel at 0.1 and 1 Hz with IC₅₀s of 1.4 μM and 5.2 μM respectively. Azimilide dihydrochloride also inhibits L-type calcium current (I_Ca) (IC₅₀ = 17.8 μM) and sodium current (I_Na) (IC₅₀ = 19 μM). Azimilide dihydrochloride can be used for the study of atrial fibrillation and ventricular fibrillation .

HY-131987S1

Ethacizine-d4
Ethacizine-d₄ is the deuterium labeled Ethacizine (HY-131987). Ethacizine is an antiarrhythmic agent with inhibitory activity on sodium channels.

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