(-)-Sparteine sulfate pentahydrate
(-)-Sparteine sulfate pentahydrate ((-)-Lupinidine sulfate pentahydrate) is a chiral proton base and catalytic promoter. (-)-Sparteine sulfate pentahydrate promotes the enantioselective carbolithiation of cinnamyl derivatives with primary and secondary organolithium reagents. (-)-Sparteine sulfate pentahydrate forms mixed aggregates with lithium halides. As an exogenous chiral base, (-)-Sparteine sulfate pentahydrate deprotonates palladium-bound secondary alcohols, promotes the formation of palladium-alkoxide species, and alters the rate-limiting step of the catalytic cycle, thereby affecting reaction rate and enantioselectivity.
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- CAS No.: 6160-12-9
- Formula: C15H38N2O9S
- Molecular Weight:422.54
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
(-)-Sparteine sulfate pentahydrate promotes the enantioselective carbolithiation of various cinnamyl derivatives (including alcohol, ether, amine and homoallylic alcohol derivatives) with primary and secondary alkyllithiums[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 6160-12-9
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Appearance Solid
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Molecular Weight 422.54
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Formula C15H38N2O9S
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SMILES
O=S(O)(O)=O.[H][C@]12C[C@](CN3[C@]2([H])CCCC3)([H])[C@@](CCCC4)([H])N4C1.O.O.O.O.O
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Synonyms
(-)-Lupinidine sulfate pentahydrate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro:
DMSO : ≥ 100 mg/mL (236.66 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (5.92 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (5.92 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (285 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3666 mL | 11.8332 mL | 23.6664 mL | 59.1660 mL |
| 5 mM | 0.4733 mL | 2.3666 mL | 4.7333 mL | 11.8332 mL | |
| 10 mM | 0.2367 mL | 1.1833 mL | 2.3666 mL | 5.9166 mL | |
| 15 mM | 0.1578 mL | 0.7889 mL | 1.5778 mL | 3.9444 mL | |
| 20 mM | 0.1183 mL | 0.5917 mL | 1.1833 mL | 2.9583 mL | |
| 25 mM | 0.0947 mL | 0.4733 mL | 0.9467 mL | 2.3666 mL | |
| 30 mM | 0.0789 mL | 0.3944 mL | 0.7889 mL | 1.9722 mL | |
| 40 mM | 0.0592 mL | 0.2958 mL | 0.5917 mL | 1.4791 mL | |
| 50 mM | 0.0473 mL | 0.2367 mL | 0.4733 mL | 1.1833 mL | |
| 60 mM | 0.0394 mL | 0.1972 mL | 0.3944 mL | 0.9861 mL | |
| 80 mM | 0.0296 mL | 0.1479 mL | 0.2958 mL | 0.7396 mL | |
| 100 mM | 0.0237 mL | 0.1183 mL | 0.2367 mL | 0.5917 mL |
(-)-Sparteine sulfate pentahydrate Related Classifications
HY-B1304 Related Classifications
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Keywords
- (-)-Sparteine sulfate
- 6160-12-9
- (-)-Lupinidine sulfate
- Biochemical Assay Reagents
- lithium halide
- palladium(II) center
- secondary alcohols
- primary organolithiums
- cinnamyl derivatives
- palladium-alkoxide species
- Br?nsted base
- primary alkyllithiums
- secondary alkyllithiums
- secondary organolithiums
- Inhibitor
- inhibitor
- inhibit