1. Membrane Transporter/Ion Channel
  2. Sodium Channel
  3. Ethacizine hydrochloride

Ethacizine hydrochloride (Synonyms: Ethacizin; NIK-244)

Cat. No.: HY-135121
Handling Instructions

Ethacizine hydrochloride (Ethacizin; NIK-244) is a longer-lasting Class Ic antiarrhythmic agent than Flecainide. Ethacizine hydrochloride (Ethacizin; NIK-244) inhibits the depolarizing current responsible for the intraatrial and His-Purkinje-ventricular conduction.

For research use only. We do not sell to patients.

Ethacizine hydrochloride Chemical Structure

Ethacizine hydrochloride Chemical Structure

CAS No. : 57530-40-2

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Description

Ethacizine hydrochloride (Ethacizin; NIK-244) is a longer-lasting Class Ic antiarrhythmic agent than Flecainide[1]. Ethacizine hydrochloride (Ethacizin; NIK-244) inhibits the depolarizing current responsible for the intraatrial and His-Purkinje-ventricular conduction[2].

In Vivo

NIK-244 (1-300 ug) injects directly into the SA node and PM preparations shows negative chronotropic, negative inotropic and coronary vasodilator[1].

Molecular Weight

449.99

Formula

C₂₂H₂₈ClN₃O₃S

CAS No.

57530-40-2

SMILES

O=C(OCC)NC(C=C1N2C(CCN(CC)CC)=O)=CC=C1SC3=C2C=CC=C3.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

EthacizineEthacizinNIK-244NIK244NIK 244Sodium ChannelNa channelsNa+ channelsAntiarrhythmicdepolarizeInhibitorinhibitorinhibit

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Ethacizine hydrochloride
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