57530-40-2
57530-40-2
Chemical Structure
Ethacizine hydrochloride
Synonym(s): Ethacizin; NIK-244
- CAS No.: 57530-40-2
- Formula:C22H28ClN3O3S
- Molecular Weight:449.99
IUPAC Name: ethyl (10-(3-(diethylamino)propanoyl)-10H-phenothiazin-2-yl)carbamate hydrochloride
InChIKey: VHNXQKLWIQHSOY-UHFFFAOYSA-N
SMILES: O=C(OCC)NC(C=C1N2C(CCN(CC)CC)=O)=CC=C1SC3=C2C=CC=C3.[H]Cl
Biological Activity: Ethacizine hydrochloride (Ethacizin; NIK-244) is a longer-lasting Class Ic antiarrhythmic agent than Flecainide[1]. Ethacizine hydrochloride (Ethacizin; NIK-244) inhibits the depolarizing current responsible for the intraatrial and His-Purkinje-ventricular conduction[2].
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Ethacizine hydrochloride | 99.25% | Ethacizine hydrochloride (Ethacizin; NIK-244) is a longer-lasting Class Ic antiarrhythmic agent than Flecainide. Ethacizine hydrochloride (Ethacizin; NIK-244) inhibits the depolarizing current responsible for the intraatrial and His-Purkinje-ventricular conduction. | ||||||||||||||||||||
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Ethacizine hydrochloride (Standard) | ≥98% | Ethacizine (hydrochloride) (Standard) is the analytical standard of Ethacizine (hydrochloride). This product is intended for research and analytical applications. Ethacizine hydrochloride (Ethacizin; NIK-244) is a longer-lasting Class Ic antiarrhythmic agent than Flecainide. Ethacizine hydrochloride (Ethacizin; NIK-244) inhibits the depolarizing current responsible for the intraatrial and His-Purkinje-ventricular conduction. | ||||||||||||||||||||
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References
- [1]. Sugiyama A, et al. Comparison of cardiovascular effects of a novel class Ic antiarrhythmic agent, NIK-244, with those of flecainide in isolated canine heart preparations cross-circulated with a donor dog.Jpn J Pharmacol. 1991 May;56(1):1-12. [Content Brief]
- [2]. Satoh H, et al. An electrophysiological comparison of a novel class Ic antiarrhythmic agent, NIK-244 (ethacizin) and flecainide in canine ventricular muscle.Br J Pharmacol. 1989 Nov;98(3):827-32.Med Chem. 2019 Nov 6:115132. [Content Brief]
