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Cat. No.: HY-B0772AR

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Nifekalant hydrochloride (Standard)

Name: Nifekalant hydrochloride (Standard)
Brand: MedChemExpress
SKU: HY-B0772AR
Availability: PreOrder

(Synonyms: MS-551 (Standard))

Nifekalant (hydrochloride) (Standard) is the analytical standard of Nifekalant (hydrochloride). This product is intended for research and analytical applications. Nifekalant hydrochloride (MS-551), a class III antiarrhythmic agent, is a IKr potassium channel blocker with an IC₅₀ of 10 µM. Nifekalant hydrochloride can be used for refractory ventricular tachyarrhythmias research.

For research use only. We do not sell to patients.

CAS No.: 130656-51-8
Formula: C₁₉H₂₈ClN₅O₅
Molecular Weight:441.91

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Nifekalant hydrochloride (Standard) Chemical Structure

CAS No.: 130656-51-8

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HY-B0772A

Nifekalant hydrochloride

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Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 130656-51-8
Molecular Weight 441.91
Formula C₁₉H₂₈ClN₅O₅
SMILES

[H]Cl.O=C1N(C)C(C=C(NCCN(CCO)CCCC2=CC=C([N+]([O-])=O)C=C2)N1C)=O
Synonyms

MS-551 (Standard)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

References

[1]. Lü-Pei Du, et al. The pharmacophore hypotheses of I(Kr) potassium channel blockers: novel class III antiarrhythmic agents. Bioorg Med Chem Lett. 2004 Sep 20;14(18):4771-7. [Content Brief]

[2]. Ioannis N Pantazopoulos, et al. Nifekalant in the treatment of life-threatening ventricular tachyarrhythmias. World J Cardiol. 2011 Jun 26;3(6):169-76. [Content Brief]

[3]. J Chen, et al. IK independent class III actions of MS-551 compared with sematilide and dofetilide during reperfusion in anaesthetized rats. Br J Pharmacol. 1996 Nov;119(5):937-42. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Nifekalant hydrochloride (Standard)

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Nifekalant hydrochloride (Standard)