Amiodarone-d10 hydrochloride
Based on 1 Customer Validation
Amiodarone-d10 (hydrochloride) is the deuterium labeled Amiodarone. Amiodarone hydrochloride is an antiarrhythmic agent for inhibition of ATP-sensitive potassium channel with an IC50 of 19.1 μM.
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- Purity : 98.81%
- CAS No.: 1261393-77-4
- 화학식: C25H20D10ClI2NO3
- 분자량:691.83
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보관:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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용액&용해도
- Protocol
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
신청
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1261393-77-4
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Unlabeled CAS 1951-25-3
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Appearance Solid
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분자량 691.83
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화학식 C25H20D10ClI2NO3
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Color Light yellow to yellow
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SMILES
O=C(C1=CC(I)=C(C(I)=C1)OCCN(C([2H])([2H])C([2H])([2H])[2H])C([2H])([2H])C([2H])([2H])[2H])C2=C(CCCC)OC3=CC=CC=C23.Cl
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
용액&용해도
In Vitro:
DMSO : 200 mg/mL (289.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocol
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
순도&문서
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Singh, B.N. and E.M. Vaughan Williams, The effect of amiodarone, a new anti-anginal drug, on cardiac muscle. Br J Pharmacol, 1970. 39(4): p. 657-67. [Content Brief]
[3]. Rosenbaum, M.B., et al., Clinical efficacy of amiodarone as an antiarrhythmic agent. Am J Cardiol, 1976. 38(7): p. 934-44. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.4454 mL | 7.2272 mL | 14.4544 mL | 36.1360 mL |
| 5 mM | 0.2891 mL | 1.4454 mL | 2.8909 mL | 7.2272 mL | |
| 10 mM | 0.1445 mL | 0.7227 mL | 1.4454 mL | 3.6136 mL | |
| 15 mM | 0.0964 mL | 0.4818 mL | 0.9636 mL | 2.4091 mL | |
| 20 mM | 0.0723 mL | 0.3614 mL | 0.7227 mL | 1.8068 mL | |
| 25 mM | 0.0578 mL | 0.2891 mL | 0.5782 mL | 1.4454 mL | |
| 30 mM | 0.0482 mL | 0.2409 mL | 0.4818 mL | 1.2045 mL | |
| 40 mM | 0.0361 mL | 0.1807 mL | 0.3614 mL | 0.9034 mL | |
| 50 mM | 0.0289 mL | 0.1445 mL | 0.2891 mL | 0.7227 mL | |
| 60 mM | 0.0241 mL | 0.1205 mL | 0.2409 mL | 0.6023 mL | |
| 80 mM | 0.0181 mL | 0.0903 mL | 0.1807 mL | 0.4517 mL | |
| 100 mM | 0.0145 mL | 0.0723 mL | 0.1445 mL | 0.3614 mL |
Amiodarone-d10 hydrochloride Related Classifications
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