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Cat. No.: HY-126562R

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Piperlonguminine (Standard)

Piperlonguminine (Standard) is the analytical standard of Piperlonguminine (HY-126562). This product is intended for research and analytical applications. Piperlonguminine is a cytochrome P450 (CYP450) inhibitor. Piperlonguminine also inhibits the growth of epimastigotes and intracellular amastigotes of Trypanosoma cruzi, with IC₅₀ values of 53.8 and 33.9 μM, respectively. Piperlonguminine regulates HMGB1/TLR4-NF-κB/MAPK-related inflammatory responses, endothelial protein C receptor (EPCR) shedding, melanogenesis, glycolipid metabolism, ischemic brain injury and tumor growth. Piperlonguminine can be used in research on hyperlipidemia, sepsis, Chagas disease, ischemic stroke, sarcoma and severe acute pancreatitis-associated lung injury.

For research use only. We do not sell to patients.

CAS No.: 5950-12-9
Formula: C₁₆H₁₉NO₃
Molecular Weight:273.33

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Piperlonguminine (Standard) Chemical Structure

CAS No.: 5950-12-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

HY-126562
Piperlonguminine

Product Information
- Information
- Application
Chemical Information
Purity & Documentation
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Product Information

Information

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 5950-12-9
Molecular Weight 273.33
Formula C₁₆H₁₉NO₃
SMILES

O=C(NCC(C)C)/C=C/C=C/C1=CC=C(OCO2)C2=C1
Structure Classification
- Alkaloids
- Other Alkaloids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

References

[1]. Wang H, et al. Protection effect of piperine and piperlonguminine from Piper longum L. alkaloids against rotenone-induced neuronal injury. Brain research. 2016 May 15;1639:214-27.

[2]. Ku SK, et al. Vascular barrier protective effects of piperlonguminine in vitro and in vivo. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 2014 May;63(5):369-79.

[3]. Sarnaizul E, et al. The preparation and antihyperlipidaemic assay of piperlonguminine in vivo. Phytochemistry Letters. 2012, article in press.

[4]. Bezerra DP, et al. In vivo growth inhibition of sarcoma 180 by piperlonguminine, an alkaloid amide from the Piper species. Journal of applied toxicology : JAT. 2008 Jul;28(5):599-607. [Content Brief]

[5]. Lee W, et al. Barrier protective effects of piperlonguminine in LPS-induced inflammation in vitro and in vivo. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2013 Aug;58:149-57.

[6]. Chi Y, et al. Metabolic activation and cytochrome P450 inhibition of piperlonguminine mediated by CYP3A4. International journal of biological macromolecules. 2024 May;268(Pt 2):131502.

[7]. Ku SK, et al. Piperlonguminine downregulates endothelial protein C receptor shedding in vitro and in vivo. Inflammation. 2014 Apr;37(2):435-42.

[8]. Yamaguchi I, et al. Adipogenic effects of piperlonguminine in 3T3-L1 cells and plasma concentrations of several amide constituents from Piper chaba extracts after treatment of mice. Journal of Natural Medicines. 2013.

[9]. Kim KS, et al. Inhibitory effect of piperlonguminine on melanin production in melanoma B16 cell line by downregulation of tyrosinase expression. Pigment cell research. 2006 Feb;19(1):90-8.

[10]. Veiga-Santos P, et al. The natural compounds piperovatine and piperlonguminine induce autophagic cell death on Trypanosoma cruzi. Acta tropica. 2013 Mar;125(3):349-56.

[11]. Yang T, et al. Piperlonguminine is neuroprotective in experimental rat stroke. International immunopharmacology. 2014 Dec;23(2):447-51. [Content Brief]

[12]. Hu Q, et al. Effects of piperlonguminine on lung injury in severe acute pancreatitis via the TLR4/NF-κB pathway. European journal of histochemistry : EJH. 2023 Mar 20;67(2):3639. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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