2. Sematilide

Sematilide (CK-1752) is a selective IKr channel blocker. Sematilide causes a concentration-dependent inhibition of the delayed rectifier K+ current (IC50=25 μM). Sematilide is a class III antiarrhythmic agent.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Sematilide hydrochloride) usually boasts enhanced water solubility and stability.

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Sematilide Chemical Structure

Sematilide Chemical Structure

CAS No. : 101526-83-4

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Sematilide Related Antibodies

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Description

Sematilide (CK-1752) is a selective IKr channel blocker. Sematilide causes a concentration-dependent inhibition of the delayed rectifier K+ current (IC50=25 μM). Sematilide is a class III antiarrhythmic agent[1].

IC50 & Target

IC50: 25 μM (K+ current)[1]
In Vitro

Application of 10, 30, 100 and 300 μM Sematilide causes a concentration-dependent inhibition of the delayed rectifier K+ current (IC50=25 μM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sematilide Related Antibodies
In Vivo

Sematilide (0.3-1.0 mg/kg, intravenously i.v.) is effective in a canine model of arrhythmia[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mongrel dogs of either sex (10-18 kg body weight)[2]
Dosage: 0.3, 1, 3, and 10 mg/kg
Administration: I.v. infusions
Result: Demonstrated antiarrhythmic effects at 0.3 and 3.0 mg/kg.
Molecular Weight

313.42

Formula

C14H23N3O3S
CAS No.
SMILES

O=C(NCCN(CC)CC)C1=CC=C(NS(=O)(C)=O)C=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sematilide101526-83-4CK-1752CK1752CK 1752Inhibitorinhibitorinhibit

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