Sematilide
Sematilide (CK-1752) is a selective IKr channel blocker. Sematilide causes a concentration-dependent inhibition of the delayed rectifier K+ current (IC50=25 μM). Sematilide is a class III antiarrhythmic agent.
For research use only. We do not sell to patients.
- CAS No.: 101526-83-4
- Formula: C14H23N3O3S
- Molecular Weight:313.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
IC50: 25 μM (K+ current)[1]
In Vitro
Application of 10, 30, 100 and 300 μM Sematilide causes a concentration-dependent inhibition of the delayed rectifier K+ current (IC50=25 μM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mongrel dogs of either sex (10-18 kg body weight)[2]
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Dosage:0.3, 1, 3, and 10 mg/kg
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Administration:I.v. infusions
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Result:Demonstrated antiarrhythmic effects at 0.3 and 3.0 mg/kg.
Chemical Information
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CAS No. 101526-83-4
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Molecular Weight 313.42
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Formula C14H23N3O3S
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SMILES
O=C(NCCN(CC)CC)C1=CC=C(NS(=O)(C)=O)C=C1
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Synonyms
CK-1752
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Sematilide Related Classifications
HY-101436 Related Classifications
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